Evaluation of the protective effect of capric acid on behavioral and biochemical alterations in valproic acid-induced model of autism

IF 4.4 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Neurochemistry international Pub Date : 2024-05-13 DOI:10.1016/j.neuint.2024.105767

Nikhila Shekhar, Ajit Kumar Thakur

{"title":"Evaluation of the protective effect of capric acid on behavioral and biochemical alterations in valproic acid-induced model of autism","authors":"Nikhila Shekhar, Ajit Kumar Thakur","doi":"10.1016/j.neuint.2024.105767","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim and objective</h3><p>The purpose of the study is to determine the neuroprotective effect of capric acid on sodium valproate-induced model of autism.</p></div><div><h3>Methods</h3><p>In this study, the effect of CA was observed in animals with single dose of valproic acid (600 mg/kg, <em>i. p.</em>) where the disease condition was confirmed by developmental impairment in pups. Behavioral tests that assess anxiety, depression, stereotypical and repetitive behavior, social interaction, learning and memory, and other confounding variables were performed. Subsequently, oxidative stress parameters, pro-inflammatory cytokine levels and mitochondrial complex activities in the selected brain regions were analyzed.</p></div><div><h3>Results</h3><p>Valproic acid successfully produced autism-like symptoms from post-natal day 7 and also demonstrated impairment in social behavior, learning and memory, and anxiety and depression. Valproic acid was found to produce oxidative stress and neuro-inflammation in the hippocampus, prefrontal cortex, and cerebellum. Treatment with capric acid produced a positive effect on the alterations with maximum effects evident at 400 mg/kg, <em>p. o.</em> through amelioration of behavioral as well as biochemical changes.</p></div><div><h3>Conclusion</h3><p>The current study concluded that capric acid could act as a likely candidate for the treatment and management of autism <em>via</em> significant modulation of neurobehavioral parameters, oxidative stress, mitochondrial dysfunction and inflammatory markers.</p></div>","PeriodicalId":398,"journal":{"name":"Neurochemistry international","volume":null,"pages":null},"PeriodicalIF":4.4000,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurochemistry international","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0197018624000949","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Aim and objective

The purpose of the study is to determine the neuroprotective effect of capric acid on sodium valproate-induced model of autism.

Methods

In this study, the effect of CA was observed in animals with single dose of valproic acid (600 mg/kg, i. p.) where the disease condition was confirmed by developmental impairment in pups. Behavioral tests that assess anxiety, depression, stereotypical and repetitive behavior, social interaction, learning and memory, and other confounding variables were performed. Subsequently, oxidative stress parameters, pro-inflammatory cytokine levels and mitochondrial complex activities in the selected brain regions were analyzed.

Results

Valproic acid successfully produced autism-like symptoms from post-natal day 7 and also demonstrated impairment in social behavior, learning and memory, and anxiety and depression. Valproic acid was found to produce oxidative stress and neuro-inflammation in the hippocampus, prefrontal cortex, and cerebellum. Treatment with capric acid produced a positive effect on the alterations with maximum effects evident at 400 mg/kg, p. o. through amelioration of behavioral as well as biochemical changes.

Conclusion

The current study concluded that capric acid could act as a likely candidate for the treatment and management of autism via significant modulation of neurobehavioral parameters, oxidative stress, mitochondrial dysfunction and inflammatory markers.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

评估己酸对丙戊酸诱导的自闭症模型中行为和生化改变的保护作用。

目的和目标本研究旨在确定己酸对丙戊酸钠诱导的自闭症模型的神经保护作用：本研究观察了己酸对单剂丙戊酸钠（600 毫克/千克，静脉注射）诱导的自闭症动物的影响。进行的行为测试包括焦虑、抑郁、刻板和重复行为、社会交往、学习和记忆以及其他混杂变量。随后，对选定脑区的氧化应激参数、促炎细胞因子水平和线粒体复合物活性进行了分析：结果：丙戊酸从出生后第 7 天起就能成功地产生类似自闭症的症状，并表现出社交行为、学习和记忆、焦虑和抑郁等方面的障碍。研究发现，丙戊酸会在海马、前额叶皮层和小脑中产生氧化应激和神经炎症。使用癸酸治疗对这些变化产生了积极影响，通过改善行为和生化变化，400 毫克/千克（口服）时效果最明显：目前的研究认为，癸酸可以通过显著调节神经行为参数、氧化应激、线粒体功能障碍和炎症标志物来治疗和控制自闭症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Neurochemistry international 医学-神经科学

CiteScore

8.40

自引率

2.40%

发文量

128

审稿时长

37 days

期刊介绍： Neurochemistry International is devoted to the rapid publication of outstanding original articles and timely reviews in neurochemistry. Manuscripts on a broad range of topics will be considered, including molecular and cellular neurochemistry, neuropharmacology and genetic aspects of CNS function, neuroimmunology, metabolism as well as the neurochemistry of neurological and psychiatric disorders of the CNS.