Optogenetic therapeutic strategies for diabetes mellitus

IF 3 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Journal of Diabetes Pub Date : 2024-05-16 DOI:10.1111/1753-0407.13557
Xin Deng, Dandan Peng, Yuanfa Yao, Ke Huang, Jinling Wang, Zhihao Ma, Junfen Fu, Yingke Xu
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Abstract

Diabetes mellitus (DM) is a common chronic disease affecting humans globally. It is characterized by abnormally elevated blood glucose levels due to the failure of insulin production or reduction of insulin sensitivity and functionality. Insulin and glucagon-like peptide (GLP)-1 replenishment or improvement of insulin resistance are the two major strategies to treat diabetes. Recently, optogenetics that uses genetically encoded light-sensitive proteins to precisely control cell functions has been regarded as a novel therapeutic strategy for diabetes. Here, we summarize the latest development of optogenetics and its integration with synthetic biology approaches to produce light-responsive cells for insulin/GLP-1 production, amelioration of insulin resistance and neuromodulation of insulin secretion. In addition, we introduce the development of cell encapsulation and delivery methods and smart bioelectronic devices for the in vivo application of optogenetics-based cell therapy in diabetes. The remaining challenges for optogenetics-based cell therapy in the clinical translational study are also discussed.

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糖尿病的光遗传学治疗策略。
糖尿病(DM)是一种影响全球人类的常见慢性疾病。由于胰岛素分泌不足或胰岛素敏感性和功能降低,导致血糖水平异常升高。补充胰岛素和胰高血糖素样肽(GLP)-1 或改善胰岛素抵抗是治疗糖尿病的两大策略。最近,利用基因编码的光敏蛋白精确控制细胞功能的光遗传学被视为治疗糖尿病的新策略。在此,我们总结了光遗传学的最新发展及其与合成生物学方法的整合,以生产光反应细胞,用于胰岛素/GLP-1的生产、改善胰岛素抵抗和胰岛素分泌的神经调节。此外,我们还介绍了细胞封装和输送方法以及智能生物电子设备的开发情况,以便在糖尿病患者体内应用基于光遗传学的细胞疗法。我们还讨论了基于光遗传学的细胞疗法在临床转化研究中仍面临的挑战。
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来源期刊
Journal of Diabetes
Journal of Diabetes ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
2.20%
发文量
94
审稿时长
>12 weeks
期刊介绍: Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.
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