Association between the skeletal muscle mass to visceral fat area ratio and metabolic dysfunction-associated fatty liver disease: A cross-sectional study of NHANES 2017–2018

IF 3 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Journal of Diabetes Pub Date : 2024-05-16 DOI:10.1111/1753-0407.13569
Zhiliang Mai, Yinfei Chen, Hua Mao, Lisheng Wang
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Abstract

Background and Aims

Previous studies have shown that sarcopenic obesity (SO) was associated with nonalcoholic fatty liver disease (NAFLD). However, research is limited in the context of the NAFLD renamed as metabolic dysfunction-associated steatotic liver disease (MASLD) defined by updated diagnostic criteria. The aim of this study was to use the index skeletal muscle mass to visceral fat area ratio (SVR) to describe SO in a large and representative US population (National Health and Nutrition Examination Survey 2017–2018) of adults and investigate their association with MASLD.

Methods

A total of 2087 individuals were included in the analysis. SVR was calculated according to the measurement of dual-energy x-ray absorptiometry and MASLD was diagnosed with controlled attenuation parameter scores and cardiometabolic risk factors. SVR was divided into tertiles. Logistic regression adjusted for confounders was used to evaluate the association between SVR and MASLD. Several sensitivity analyses were performed to test the robustness of our findings.

Results

In a multivariate logistic regression analysis, a significant association between SVR and MASLD was shown (odds ratio [OR]: 3.11, 95% confidence interval [CI]: 1.31–7.39, p = .010 for middle levels of SVR; OR: 3.82, 95% CI: 1.45–10.08, p = .007 for lowest levels of SVR). The sensitivity analyses confirmed that the association was robust.

Conclusion

Our findings imply that decreased SVR is linked to MASLD.

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骨骼肌质量与内脏脂肪面积比值与代谢功能障碍相关性脂肪肝之间的关系:NHANES 2017-2018 年度横断面研究。
背景和目的:以往的研究表明,肌肉疏松性肥胖(SO)与非酒精性脂肪肝(NAFLD)有关。然而,根据最新诊断标准定义的非酒精性脂肪肝更名为代谢功能障碍相关性脂肪肝(MASLD),在此背景下的研究却很有限。本研究旨在使用骨骼肌质量与内脏脂肪面积比(SVR)指数来描述具有代表性的大规模美国成年人群(2017-2018 年全国健康与营养调查)中的 SO,并调查其与 MASLD 的关联:共有2087人被纳入分析。SVR 根据双能 X 射线吸收测量法的测量结果进行计算,MASLD 根据受控衰减参数评分和心脏代谢风险因素进行诊断。SVR 被分为三等分。采用调整混杂因素后的逻辑回归评估 SVR 与 MASLD 之间的关系。我们还进行了多项敏感性分析,以检验研究结果的稳健性:结果:在多变量逻辑回归分析中,SVR 与 MASLD 之间存在显著关联(几率比 [OR]:3.11,95% 置信区间 [CI]:1.31-7.39, p = .010 for middle levels of SVR; OR:3.82,95% 置信区间:1.45-10.08,P = .007)。敏感性分析证实这种关联是稳健的:我们的研究结果表明,SVR 的下降与 MASLD 有关。
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来源期刊
Journal of Diabetes
Journal of Diabetes ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
2.20%
发文量
94
审稿时长
>12 weeks
期刊介绍: Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.
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