Causal relationship of interleukin-6 and its receptor on sarcopenia traits using mendelian randomization.

IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Nutrition Journal Pub Date : 2024-05-15 DOI:10.1186/s12937-024-00958-w
Baixing Chen, Shaoshuo Li, Shi Lin, Hang Dong
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Abstract

Background: Previous research has extensively examined the role of interleukin 6 (IL-6) in sarcopenia. However, the presence of a causal relationship between IL-6, its receptor (IL-6R), and sarcopenia remains unclear.

Method: In this study, we utilized summary-level data from genome-wide association studies (GWAS) focused on appendicular lean mass (ALM), hand grip strength, and walking pace. Single nucleotide polymorphisms (SNPs) were employed as genetic instruments for IL-6 and IL-6R to estimate the causal effect of sarcopenia traits. We adopted the Mendelian randomization (MR) approach to investigate these associations using the inverse variance weighted (IVW) method as the primary analytical approach. Additionally, we performed sensitivity analyses to validate the reliability of the MR results.

Result: This study revealed a significant negative association between main IL-6R and eQTL IL-6R on the left grip strength were - 0.013 (SE = 0.004, p < 0.001) and -0.029 (SE = 0.007, p < 0.001), respectively. While for the right grip strength, the estimates were - 0.011 (SE = 0.001, p < 0.001) and - 0.021 (SE = 0.008, p = 0.005). However, no evidence of an association for IL-6R with ALM and walking pace. In addition, IL-6 did not affect sarcopenia traits.

Conclusion: Our study findings suggest a negative association between IL-6R and hand grip strength. Additionally, targeting IL-6R may hold potential value as a therapeutic approach for the treatment of hand grip-related issues.

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利用泯灭随机法研究白细胞介素-6及其受体与肌肉疏松症特征的因果关系。
背景:以往的研究广泛探讨了白细胞介素6(IL-6)在肌肉疏松症中的作用。然而,IL-6、其受体(IL-6R)与肌肉疏松症之间是否存在因果关系仍不清楚:在这项研究中,我们利用了来自全基因组关联研究(GWAS)的汇总数据,这些数据主要集中在关节瘦体重(ALM)、手握力和步行速度上。单核苷酸多态性(SNPs)被用作 IL-6 和 IL-6R 的遗传工具,以估计肌肉疏松症性状的因果效应。我们采用孟德尔随机化(MR)方法,以反向方差加权法(IVW)作为主要分析方法,研究这些关联。此外,我们还进行了敏感性分析,以验证 MR 结果的可靠性:本研究发现,主 IL-6R 和 eQTL IL-6R 对左手握力的影响为 - 0.013(SE = 0.004,p 结论:我们的研究结果表明,主 IL-6R 和 eQTL IL-6R 对左手握力的影响呈显著负相关:我们的研究结果表明,IL-6R 与手部握力之间存在负相关。此外,以 IL-6R 为靶点可能具有治疗手部握力相关问题的潜在价值。
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来源期刊
Nutrition Journal
Nutrition Journal NUTRITION & DIETETICS-
CiteScore
9.80
自引率
0.00%
发文量
68
审稿时长
4-8 weeks
期刊介绍: Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.
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