Phase angle as an indicator of sarcopenia and malnutrition in patients with chronic obstructive pulmonary disease

IF 2.4 Q2 RESPIRATORY SYSTEM Respiratory investigation Pub Date : 2024-05-17 DOI:10.1016/j.resinv.2024.05.012

Tomoyuki Murakami , Takeshi Kobayashi , Hiroto Ono , Hayato Shibuma , Kazuhiro Tsuji , Etsuhiro Nikkuni , Naoki Mori , Shinya Ohkouchi , Masao Tabata , Toshiya Irokawa , Hiromasa Ogawa , Tsuneyuki Takahashi , Hajime Kurosawa

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Abstract

Background

Phase angle (PhA), which is measured using bioelectrical impedance analysis, is an indicator of muscle quality and malnutrition. PhA has been shown to be correlated with sarcopenia and malnutrition; however, studies on patients with chronic obstructive pulmonary disease (COPD) are limited. In this study, we investigated the correlation between PhA and sarcopenia and malnutrition and determined the cutoff values of PhA for those in patients with COPD.

Methods

This study included 105 male patients with COPD (mean age 75.7 ± 7.7 years, mean forced expiratory volume in 1s % predicted [%FEV₁] 57.0 ± 20.1%) and 12 male controls (mean age 74.1 ± 3.8 years) who were outpatients between December 2019 and March 2024. PhA was measured using the InBody S10, and its correlation with sarcopenia and malnutrition was assessed. The cutoff PhA values for sarcopenia and malnutrition were determined using receiver operating characteristic curves.

Results

The prevalence rates of sarcopenia and malnutrition were 31% and 22%, respectively, in patients with COPD. PhA significantly correlated with sarcopenia- and malnutrition-related indicators. Multivariate logistic regression analysis independently correlated PhA with sarcopenia and malnutrition. The cutoff values of the PhA for sarcopenia and malnutrition were 4.75° (AUC = 0.78, 95% CI = 0.68–0.88) and 4.25° (AUC = 0.75, 95% CI = 0.63–0.86), respectively.

Conclusions

PhA was significantly correlated with sarcopenia and malnutrition in Japanese patients with COPD and may be a useful diagnostic indicator.

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相位角作为慢性阻塞性肺病患者肌少症和营养不良的指标

背景通过生物电阻抗分析法测量的相位角（PhA）是肌肉质量和营养不良的指标。有研究表明，PhA 与肌肉疏松症和营养不良相关；但针对慢性阻塞性肺病（COPD）患者的研究却很有限。本研究调查了 PhA 与肌肉疏松症和营养不良之间的相关性，并确定了慢性阻塞性肺病患者 PhA 的临界值。方法本研究纳入了 2019 年 12 月至 2024 年 3 月期间门诊的 105 名男性慢性阻塞性肺病患者（平均年龄为 75.7 ± 7.7 岁，1 秒内平均用力呼气容积预测值 [%FEV1] 为 57.0 ± 20.1%）和 12 名男性对照组患者（平均年龄为 74.1 ± 3.8 岁）。使用 InBody S10 测量 PhA，并评估其与肌肉疏松症和营养不良的相关性。结果慢性阻塞性肺病患者的肌少症和营养不良患病率分别为31%和22%。PhA 与肌少症和营养不良相关指标有明显相关性。多变量逻辑回归分析将 PhA 与肌少症和营养不良独立相关。结论PhA与日本慢性阻塞性肺病患者的肌少症和营养不良显著相关，可能是一个有用的诊断指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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