Respiratory Syncytial Virus and Influenza Infections in Children in Ulaanbaatar, Mongolia, 2015–2021

IF 4.3 4区 医学 Q1 INFECTIOUS DISEASES Influenza and Other Respiratory Viruses Pub Date : 2024-05-16 DOI:10.1111/irv.13303
Lien Anh Ha Do, Naranzul Tsedenbal, Chimidregzen Khishigmunkh, Bazarkhuu Tserendulam, Lkhagvadorj Altanbumba, Dashtseren Luvsantseren, Munkhchuluun Ulziibayar, Bujinlkham Suuri, Dorj Narangerel, Bilegtsaikhan Tsolmon, Sodbayar Demberelsuren, Casey L Pell, Sam Manna, Catherine Satzke, Cattram Nguyen, Tuya Mungun, Claire von Mollendorf, Darmaa Badarch, Kim Mulholland
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引用次数: 0

Abstract

Background

Data available for RSV and influenza infections among children < 2 years in Mongolia are limited. We present data from four districts of Ulaanbaatar from April 2015 to June 2021.

Methods

This study was nested in an enhanced surveillance project evaluating pneumococcal conjugate vaccine (PCV13) impact on the incidence of hospitalized lower respiratory tract infections (LRTIs). Our study was restricted to children aged < 2 years with arterial O2 saturation < 93% and children with radiological pneumonia. Nasopharyngeal (NP) swabs collected at admission were tested for RSV and influenza using qRT-PCR. NP swabs of all patients with radiological pneumonia and of a subset of randomly selected NP swabs were tested for S. pneumoniae (S.p.) by qPCR and for serotypes by culture and DNA microarray.

Results

Among 5705 patients, 2113 (37.0%) and 386 (6.8%) had RSV and influenza infections, respectively. Children aged 2–6 months had a higher percentage of very severe RSV infection compared to those older than 6 months (42.2% versus 31.4%, p-value Fisher's exact = 0.001). S.p. carriage was detected in 1073/2281 (47.0%) patients. Among S.p. carriage cases, 363/1073 (33.8%) had S.p. and RSV codetection, and 82/1073 (7.6%) had S.p. and influenza codetection. S.p. codetection with RSV/influenza was not associated with more severe LRTIs, compared to only RSV/influenza cases.

Conclusion

In Mongolia, RSV is an important pathogen causing more severe LRTI in children under 6 months of age. Codetection of RSV or influenza virus and S.p. was not associated with increased severity.

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2015-2021 年蒙古乌兰巴托儿童呼吸道合胞病毒和流感感染情况
背景 蒙古两岁儿童感染 RSV 和流感的数据有限。我们提供了乌兰巴托市四个区 2015 年 4 月至 2021 年 6 月期间的数据。 方法 本研究嵌套在一个强化监测项目中,该项目旨在评估肺炎球菌结合疫苗(PCV13)对住院下呼吸道感染(LRTI)发病率的影响。我们的研究仅限于动脉血氧饱和度为 93% 的 2 岁儿童和患有放射性肺炎的儿童。采用 qRT-PCR 技术对入院时采集的鼻咽(NP)拭子进行 RSV 和流感检测。对所有放射性肺炎患者的鼻咽拭子和随机抽取的一部分鼻咽拭子进行了肺炎链球菌(S.p.)qPCR 检测,并通过培养和 DNA 微阵列检测血清型。 结果 在 5705 名患者中,分别有 2113 人(37.0%)和 386 人(6.8%)感染了 RSV 和流感。与 6 个月以上的儿童相比,2-6 个月的儿童感染非常严重的 RSV 的比例更高(42.2% 对 31.4%,P 值 Fisher's exact = 0.001)。在 1073/2281 例(47.0%)患者中检测到 S.p.携带。在 S.p. 携带病例中,363/1073(33.8%)例进行了 S.p. 和 RSV 编码检测,82/1073(7.6%)例进行了 S.p. 和流感编码检测。与仅检测 RSV/influenza 的病例相比,S.p. 与 RSV/influenza 的编码检测与更严重的 LRTI 无关。 结论 在蒙古,RSV 是导致 6 个月以下儿童更严重 LRTI 的重要病原体。RSV或流感病毒和S.p.的联合检测与严重程度的增加无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.20
自引率
4.50%
发文量
120
审稿时长
6-12 weeks
期刊介绍: Influenza and Other Respiratory Viruses is the official journal of the International Society of Influenza and Other Respiratory Virus Diseases - an independent scientific professional society - dedicated to promoting the prevention, detection, treatment, and control of influenza and other respiratory virus diseases. Influenza and Other Respiratory Viruses is an Open Access journal. Copyright on any research article published by Influenza and Other Respiratory Viruses is retained by the author(s). Authors grant Wiley a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its integrity is maintained and its original authors, citation details and publisher are identified.
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