Prognostic factors in Kaposi sarcoma, single centre experience

IF 1.8 4区医学 Q2 DERMATOLOGY Australasian Journal of Dermatology Pub Date : 2024-05-17 DOI:10.1111/ajd.14309

Ezgi Değerli MD, Kerem Oruç MD, Nihan Şentürk Öztaş MD, Gülin Alkan Şen MD, Şahin Bedir MD, Nebi Serkan Demirci MD, Hulusi Fuat Demirelli MD

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Abstract

Background

Kaposi sarcoma (KS) is a multicentric vascular and lymphatic neoplasm caused by human herpesvirus 8 (HHV-8). It generally concerns the elderly and immunosuppressed population. Four major clinical types of KS have been described. The most common subtype is Classical KS (CKS).

Objectives

Our retrospective study aimed to better define prognostic subgroups among patients with CKS, which is the most common in our country.

Method

Between 2014 and 2020, 43 patients with CKS were treated with local excision, radiotherapy and chemotherapy. Reviewed information included demographics, clinical features, laboratory findings, treatment responses and overall survival.

Results

During the follow-up, eight patients (18.6%) died of CKS. The complete response rate was 46.5%, partial response and stable disease 51.2%, and progressive disease 2.3% of all patients. Gender, haemoglobin level at diagnosis, and disseminated involvement were prognostic factors affecting survival in all patients.

Conclusion

We confirmed that male gender, low haemoglobin levels, and disseminated involvement are associated with poor prognosis in CKS patients. It is the only Turkish study in which prognostic analysis was performed for this rare cancer.

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卡波西肉瘤的预后因素，单中心经验。

背景：卡波西肉瘤（KS）是一种由人类疱疹病毒 8（HHV-8）引起的多中心血管和淋巴肿瘤。它通常发生在老年人和免疫抑制人群中。目前已描述了四种主要的 KS 临床类型。最常见的亚型是经典 KS（CKS）：我们的回顾性研究旨在更好地界定我国最常见的 CKS 患者的预后亚组：2014年至2020年间，43名CKS患者接受了局部切除、放疗和化疗。随访信息包括人口统计学、临床特征、实验室检查结果、治疗反应和总生存期：随访期间，有8名患者（18.6%）死于卡介苗。在所有患者中，完全应答率为46.5%，部分应答和病情稳定率为51.2%，病情进展率为2.3%。性别、诊断时的血红蛋白水平和播散性受累是影响所有患者生存期的预后因素：我们证实，男性、低血红蛋白水平和播散性受累与卡介苗患者的不良预后有关。这是土耳其唯一一项针对这种罕见癌症进行预后分析的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Australasian Journal of Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

5.00%

发文量

186

审稿时长

6-12 weeks

期刊介绍： Australasian Journal of Dermatology is the official journal of the Australasian College of Dermatologists and the New Zealand Dermatological Society, publishing peer-reviewed, original research articles, reviews and case reports dealing with all aspects of clinical practice and research in dermatology. Clinical presentations, medical and physical therapies and investigations, including dermatopathology and mycology, are covered. Short articles may be published under the headings ‘Signs, Syndromes and Diagnoses’, ‘Dermatopathology Presentation’, ‘Vignettes in Contact Dermatology’, ‘Surgery Corner’ or ‘Letters to the Editor’.