John Frew, Annika Smith, Pablo Fernandez Penas, Elisabeth Ellis, Peter Foley, Diana Rubel, Erin McMeniman, Gillian Marshman, Helen Saunders, Emma Veysey, Jenny Nicolopolous, Linda Spelman, Kurt Gebauer
Hidradenitis Suppurativa is a burdensome inflammatory skin disease with significant quality of life impact. These management guidelines were developed to direct appropriate clinical management in the Australasian context. A systematic review was used for the basis of the consensus guidelines. Thirteen clinical experts were involved in a modified Delphi consensus process to develop the guidelines and treatment algorithms. Overall management strategies include appropriate severity assessment of disease and comorbidities, multimodal therapy with systemic and local treatments, and evidence-based progression along the therapeutic ladder in the event of inadequate response. Sequential monotherapy with antibiotics and/or single agent therapy is discouraged and aggressive treatment of moderate to severe disease to capture the window of opportunity is highly emphasised. Specific considerations in the setting of disease comorbidities, pregnancy and breastfeeding are also addressed. Overall, the complex nature of HS requires a complex and multimodal therapeutic response with medical, physical and surgical therapies to achieve best patient outcomes.
{"title":"Australasian hidradenitis suppurativa management guidelines.","authors":"John Frew, Annika Smith, Pablo Fernandez Penas, Elisabeth Ellis, Peter Foley, Diana Rubel, Erin McMeniman, Gillian Marshman, Helen Saunders, Emma Veysey, Jenny Nicolopolous, Linda Spelman, Kurt Gebauer","doi":"10.1111/ajd.14388","DOIUrl":"https://doi.org/10.1111/ajd.14388","url":null,"abstract":"<p><p>Hidradenitis Suppurativa is a burdensome inflammatory skin disease with significant quality of life impact. These management guidelines were developed to direct appropriate clinical management in the Australasian context. A systematic review was used for the basis of the consensus guidelines. Thirteen clinical experts were involved in a modified Delphi consensus process to develop the guidelines and treatment algorithms. Overall management strategies include appropriate severity assessment of disease and comorbidities, multimodal therapy with systemic and local treatments, and evidence-based progression along the therapeutic ladder in the event of inadequate response. Sequential monotherapy with antibiotics and/or single agent therapy is discouraged and aggressive treatment of moderate to severe disease to capture the window of opportunity is highly emphasised. Specific considerations in the setting of disease comorbidities, pregnancy and breastfeeding are also addressed. Overall, the complex nature of HS requires a complex and multimodal therapeutic response with medical, physical and surgical therapies to achieve best patient outcomes.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Harmeet K Bhullar, Friyana Bhabha, Chris McCormack, H Miles Prince
Sneddon-Wilkinson (SW) disease is rare condition which typically occurs in the context of a monoclonal immunoglobulin and treatment options have not been well studied. Here we present a case of a 65-year-old female with SW with underlying, otherwise indolent, lymphoplasmacytic lymphoma (LPL) with an IgA paraprotein, who achieved a complete skin remission with the administration of the Bruton Tyrosine Kinase inhibitor (BTKi), acalabrutinib.
斯内登-威尔金森(SW)病是一种罕见的疾病,通常发生在单克隆免疫球蛋白的背景下,治疗方案尚未得到充分研究。我们在此介绍一例 65 岁女性 SW 患者,她患有淋巴浆细胞性淋巴瘤(LPL)并伴有 IgA 副蛋白,但病情并不严重,在服用布鲁顿酪氨酸激酶抑制剂(BTKi)阿卡鲁替尼后,皮肤症状完全缓解。
{"title":"Complete skin remission of Sneddon-Wilkinson disease with acalabrutinib.","authors":"Harmeet K Bhullar, Friyana Bhabha, Chris McCormack, H Miles Prince","doi":"10.1111/ajd.14386","DOIUrl":"https://doi.org/10.1111/ajd.14386","url":null,"abstract":"<p><p>Sneddon-Wilkinson (SW) disease is rare condition which typically occurs in the context of a monoclonal immunoglobulin and treatment options have not been well studied. Here we present a case of a 65-year-old female with SW with underlying, otherwise indolent, lymphoplasmacytic lymphoma (LPL) with an IgA paraprotein, who achieved a complete skin remission with the administration of the Bruton Tyrosine Kinase inhibitor (BTKi), acalabrutinib.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bengu Nisa Akay, Christopher Earl, Tracey Zeelie, Tony Dicker, Simon Clark, Cliff Rosendahl
Melanomas on the dorsum of the hand are exceedingly rare, with limited documentation in medical literature. This report presents seven cases of dorsal hand and finger melanomas, encompassing patients from Australia, New Zealand and Turkey, predominantly women with a mean age of 53 years. The majority were invasive, with a mean Breslow thickness of 1.1 mm and none were of lentigo maligna subtype. The rarity of dorsal hand melanomas prompts speculation into potential protective factors unique to this site, challenging existing knowledge on melanoma aetiology and sun exposure.
{"title":"Melanomas on the dorsum of the hand are extremely rare: A series of seven cases with clinical and dermatoscopic images.","authors":"Bengu Nisa Akay, Christopher Earl, Tracey Zeelie, Tony Dicker, Simon Clark, Cliff Rosendahl","doi":"10.1111/ajd.14394","DOIUrl":"https://doi.org/10.1111/ajd.14394","url":null,"abstract":"<p><p>Melanomas on the dorsum of the hand are exceedingly rare, with limited documentation in medical literature. This report presents seven cases of dorsal hand and finger melanomas, encompassing patients from Australia, New Zealand and Turkey, predominantly women with a mean age of 53 years. The majority were invasive, with a mean Breslow thickness of 1.1 mm and none were of lentigo maligna subtype. The rarity of dorsal hand melanomas prompts speculation into potential protective factors unique to this site, challenging existing knowledge on melanoma aetiology and sun exposure.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laxmi Iyengar, Patrick Hosking, Joel Dowsett, John Su
In the present study, we characterise the expression of JAK/STAT signalling in Bullous Pemphigoid (BP). Punch biopsy specimens of normal skin, lesional and perilesional skin of patients diagnosed with biopsy proven BP were utilised for immunoperoxidase labelling with commercially available antibodies for Phosphorylated STAT 1,2,3,5A and 6 (Genesearch, USA). Quantitative analysis demonstrated that in comparison to normal skin, phosphorylated STAT 2, 3, 5A and 6 were overexpressed in BP.
在本研究中,我们分析了大疱性类天疱疮(BP)中 JAK/STAT 信号的表达特征。我们利用活检证实的大疱性类天疱疮患者的正常皮肤、病变和周围皮肤的冲孔活检标本,用市售的磷酸化 STAT 1、2、3、5A 和 6 抗体(Genesearch,美国)进行免疫过氧化物酶标记。定量分析显示,与正常皮肤相比,磷酸化 STAT 2、3、5A 和 6 在 BP 中过度表达。
{"title":"Expression of JAK/STAT signalling in bullous pemphigoid.","authors":"Laxmi Iyengar, Patrick Hosking, Joel Dowsett, John Su","doi":"10.1111/ajd.14389","DOIUrl":"https://doi.org/10.1111/ajd.14389","url":null,"abstract":"<p><p>In the present study, we characterise the expression of JAK/STAT signalling in Bullous Pemphigoid (BP). Punch biopsy specimens of normal skin, lesional and perilesional skin of patients diagnosed with biopsy proven BP were utilised for immunoperoxidase labelling with commercially available antibodies for Phosphorylated STAT 1,2,3,5A and 6 (Genesearch, USA). Quantitative analysis demonstrated that in comparison to normal skin, phosphorylated STAT 2, 3, 5A and 6 were overexpressed in BP.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is tofacitinib monotherapy also effective for the treatment of Acrodermatitis continua of Hallopeau?","authors":"Danxiang Shen, Di Jin, Zhimin Lin, Fanzhang Meng, Chen Li, Zhenhua Ying","doi":"10.1111/ajd.14384","DOIUrl":"https://doi.org/10.1111/ajd.14384","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eugene Tan, Catherine Scarff, Rebecca B Saunderson, H Peter Soyer, Fiona Bruce
{"title":"Location matters! Optimizing venue selection and attendance format to lower the carbon footprint of air travel to the Australasian College of Dermatologists ASM.","authors":"Eugene Tan, Catherine Scarff, Rebecca B Saunderson, H Peter Soyer, Fiona Bruce","doi":"10.1111/ajd.14381","DOIUrl":"https://doi.org/10.1111/ajd.14381","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah L Becker, Gregory S Phillips, Jesse Keller, Radhika Sheth, Stephanie Egge, Stephanie Mengden Koon, Alex G Ortega-Loayza
Pyoderma gangrenosum (PG) can be difficult to diagnose, leading to diagnostic delay which affects patient outcomes and increases health care utilization. Among different scenarios of diagnostic delay, atypical infections can mimic PG. Here, we present a case of extensive cutaneous leishmaniasis initially misdiagnosed as the superficial granulomatous variant of PG and describe diagnostic clues to aid in differentiation.
{"title":"Leishmaniasis masquerading as pyoderma gangrenosum in a non-endemic area: A case report.","authors":"Sarah L Becker, Gregory S Phillips, Jesse Keller, Radhika Sheth, Stephanie Egge, Stephanie Mengden Koon, Alex G Ortega-Loayza","doi":"10.1111/ajd.14385","DOIUrl":"https://doi.org/10.1111/ajd.14385","url":null,"abstract":"<p><p>Pyoderma gangrenosum (PG) can be difficult to diagnose, leading to diagnostic delay which affects patient outcomes and increases health care utilization. Among different scenarios of diagnostic delay, atypical infections can mimic PG. Here, we present a case of extensive cutaneous leishmaniasis initially misdiagnosed as the superficial granulomatous variant of PG and describe diagnostic clues to aid in differentiation.</p>","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A reply to: 'Melanoma documented arising in an involuting naevus 3 years after cessation of monitoring'.","authors":"Miranda Wallace, Jim Muir","doi":"10.1111/ajd.14382","DOIUrl":"https://doi.org/10.1111/ajd.14382","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Re: The risk of psychiatric disorders in finasteride users with benign prostatic hyperplasia (BPH) and androgenetic alopecia (AGA): A population-based case-control study.","authors":"Keng Chen, Samuel Zagarella","doi":"10.1111/ajd.14380","DOIUrl":"https://doi.org/10.1111/ajd.14380","url":null,"abstract":"","PeriodicalId":8638,"journal":{"name":"Australasian Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}