A Critical Review on the Role of Probiotics in Lung Cancer Biology and Prognosis

IF 8.7 3区医学 Q1 RESPIRATORY SYSTEM Archivos De Bronconeumologia Pub Date : 2024-10-01 DOI:10.1016/j.arbres.2024.04.030

{"title":"A Critical Review on the Role of Probiotics in Lung Cancer Biology and Prognosis","authors":"","doi":"10.1016/j.arbres.2024.04.030","DOIUrl":null,"url":null,"abstract":"<div><div><span>Lung cancer remains the leading cause of cancer-related deaths worldwide. According to the American Cancer Society (ACS), it ranks as the second most prevalent type of cancer globally. Recent findings have highlighted bidirectional gut–lung interactions, known as the gut–lung axis, in the pathophysiology<span> of lung cancer. Probiotics are live microorganisms that boost host immunity when consumed adequately. The immunoregulatory mechanisms of probiotics are thought to operate through the generation of various metabolites that impact both the gut and distant organs (</span></span><em>e.g.</em><span>, the lungs) through blood. Several randomized controlled trials<span><span> have highlighted the pivotal role of probiotics in gut health especially for the prevention and treatment of malignancies, with a specific emphasis on lung cancer. Current research indicates that probiotic supplementation positively affects patients, leading to a suppression in cancer symptoms and a shortened </span>disease course<span>. While clinical trials validate the therapeutic benefits of probiotics, their precise mechanism of action remains unclear. This narrative review aims to provide a comprehensive overview of the present landscape of probiotics in the management of lung cancer.</span></span></span></div></div>","PeriodicalId":8339,"journal":{"name":"Archivos De Bronconeumologia","volume":null,"pages":null},"PeriodicalIF":8.7000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archivos De Bronconeumologia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0300289624001443","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}

引用次数: 0

Abstract

Lung cancer remains the leading cause of cancer-related deaths worldwide. According to the American Cancer Society (ACS), it ranks as the second most prevalent type of cancer globally. Recent findings have highlighted bidirectional gut–lung interactions, known as the gut–lung axis, in the pathophysiology of lung cancer. Probiotics are live microorganisms that boost host immunity when consumed adequately. The immunoregulatory mechanisms of probiotics are thought to operate through the generation of various metabolites that impact both the gut and distant organs (e.g., the lungs) through blood. Several randomized controlled trials have highlighted the pivotal role of probiotics in gut health especially for the prevention and treatment of malignancies, with a specific emphasis on lung cancer. Current research indicates that probiotic supplementation positively affects patients, leading to a suppression in cancer symptoms and a shortened disease course. While clinical trials validate the therapeutic benefits of probiotics, their precise mechanism of action remains unclear. This narrative review aims to provide a comprehensive overview of the present landscape of probiotics in the management of lung cancer.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

关于益生菌在肺癌生物学和预后中的作用的评论。

肺癌仍然是全球癌症相关死亡的主要原因。根据美国癌症协会（ACS）的数据，肺癌在全球癌症发病率中排名第二。最近的研究结果突显了肺癌病理生理学中的双向肠肺相互作用，即所谓的肠肺轴。益生菌是活的微生物，适当摄入可提高宿主免疫力。益生菌的免疫调节机制被认为是通过产生各种代谢物来实现的，这些代谢物通过血液影响肠道和远处器官（如肺部）。一些随机对照试验强调了益生菌在肠道健康中的关键作用，尤其是在预防和治疗恶性肿瘤方面，重点是肺癌。目前的研究表明，补充益生菌对患者有积极影响，可抑制癌症症状，缩短病程。虽然临床试验证实了益生菌的治疗效果，但其确切的作用机制仍不清楚。本综述旨在全面概述益生菌在肺癌治疗中的应用现状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Archivos De Bronconeumologia Medicine-Pulmonary and Respiratory Medicine

CiteScore

3.50

自引率

17.50%

发文量

330

审稿时长

14 days

期刊介绍： Archivos de Bronconeumologia is a scientific journal that specializes in publishing prospective original research articles focusing on various aspects of respiratory diseases, including epidemiology, pathophysiology, clinical practice, surgery, and basic investigation. Additionally, the journal features other types of articles such as reviews, editorials, special articles of interest to the society and editorial board, scientific letters, letters to the editor, and clinical images. Published monthly, the journal comprises 12 regular issues along with occasional supplements containing articles from different sections. All manuscripts submitted to the journal undergo rigorous evaluation by the editors and are subjected to expert peer review. The editorial team, led by the Editor and/or an Associate Editor, manages the peer-review process. Archivos de Bronconeumologia is published monthly in English, facilitating broad dissemination of the latest research findings in the field.