Archivos De Bronconeumologia最新文献

英文中文

Mediastinal Venous-Lymphatic Malformations: Thoracoscopic Resection 纵隔静脉-淋巴管畸形：胸腔镜切除术

IF 8.7 3区医学 Q1 RESPIRATORY SYSTEM

Archivos De Bronconeumologia

Pub Date : 2024-11-01 DOI: 10.1016/j.arbres.2024.07.002

引用次数: 0

Pulmonary Tropheryma whipplei Infection Diagnosed by Metagenomic Next-generation Sequencing: A Case Report 通过元基因组下一代测序诊断的肺托品菌感染：一份病例报告

IF 8.7 3区医学 Q1 RESPIRATORY SYSTEM

Archivos De Bronconeumologia

Pub Date : 2024-11-01 DOI: 10.1016/j.arbres.2024.07.014

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Sharing of Individual Participant Clinical Trial Data: It is Time to Abandon the “Look the Other Way” Attitude 共享个体参与者的临床试验数据：是时候放弃 "睁一只眼闭一只眼 "的态度了

IF 8.7 3区医学 Q1 RESPIRATORY SYSTEM

Archivos De Bronconeumologia

Pub Date : 2024-11-01 DOI: 10.1016/j.arbres.2024.07.016

引用次数: 0

CO1 CO1

IF 8.7 3区医学 Q1 RESPIRATORY SYSTEM

Archivos De Bronconeumologia

Pub Date : 2024-11-01 DOI: 10.1016/S0300-2896(24)00380-6

引用次数: 0

Transbronchial Cryobiopsy Versus Transbronchial Forceps Biopsy for Acute Cellular Rejection Detection in Lung Transplantation: A Meta-Analysis 经支气管冷冻活检与经支气管镊活检在肺移植急性细胞排斥反应检测中的应用：一项 Meta 分析。

IF 8.7 3区医学 Q1 RESPIRATORY SYSTEM

Archivos De Bronconeumologia

Pub Date : 2024-11-01 DOI: 10.1016/j.arbres.2024.06.006

Background

Transbronchial cryobiopsy (TBCB) provides larger tissue samples and improved sampling depth, but its role in diagnosing acute cellular rejection (ACR) in lung transplant patients is unclear due to limitations in existing studies. To address this, we conducted a systematic review and meta-analysis to evaluate the efficacy and safety of TBCB.

Methods

A thorough literature review was conducted to evaluate TBCB in post-lung transplant surveillance, assessing the quality of studies and conducting a meta-analysis comparing diagnostic yields of TBCB and transbronchial forceps biopsy (TBFB), as well as evaluating procedural complications.

Results

Our meta-analysis, incorporating 11 studies with a total of 915 patients, showed that TBCB had a diagnostic rate of 38.27% (225/588) for ACR post-lung transplantation, notably higher than the 35.65% (251/704) for TBFB. The inverse-variance weighted odds ratio was calculated at 2.32 (95% confidence interval: 1.24–4.32; p = 0.008). Funnel plot analysis indicated no major publication bias. Meta-analysis of 6 studies demonstrated that TBCB, compared to TBFB, significantly increased the diagnostic rate for chronic rejection post-transplantation (25.00% vs 10.93%, p = 0.005). Our meta-analysis comparing the safety of TBCB and TBFB in post-lung transplant surveillance found no significant differences in moderate to severe bleeding (5.99% vs 6.31%, p = 0.98), or pneumothorax incidence (3.90% vs 3.29%, p = 0.75).

Conclusions

Our study indicates that TBCB may enhance the diagnosis of acute and chronic rejection post-lung transplantation with a safety profile comparable to TBFB. Further research and the development of standardized procedures are warranted to ensure the safe and effective application of TBCB in broader clinical practice.

背景：经支气管低温生物切片检查（TBCB）可提供更大的组织样本并改善取样深度，但由于现有研究的局限性，其在诊断肺移植患者急性细胞排斥反应（ACR）中的作用尚不明确。针对这一问题，我们进行了一项系统回顾和荟萃分析，以评估 TBCB 的有效性和安全性：我们对肺移植术后监测中的 TBCB 进行了全面的文献综述，评估了研究质量，并进行了荟萃分析，比较了 TBCB 和经支气管镊活检（TBFB）的诊断率，并评估了手术并发症：我们的荟萃分析纳入了 11 项研究，共计 915 名患者，结果显示 TBCB 对肺移植后 ACR 的诊断率为 38.27%（225/588），明显高于 TBFB 的 35.65%（251/704）。计算得出的逆方差加权几率比为 2.32（95% 置信区间：1.24-4.32；P=0.008）。漏斗图分析表明无重大发表偏倚。对 6 项研究进行的荟萃分析表明，与 TBFB 相比，TBCB 能显著提高移植后慢性排斥反应的诊断率（25.00% vs 10.93%，p=0.005）。我们的荟萃分析比较了 TBCB 和 TBFB 在肺移植术后监测中的安全性，发现两者在中重度出血（5.99% vs 6.31%，P=0.98）或气胸发生率（3.90% vs 3.29%，P=0.75）方面无明显差异：我们的研究表明，TBCB 可增强肺移植术后急性和慢性排斥反应的诊断，其安全性与 TBFB 相当。为确保在更广泛的临床实践中安全有效地应用 TBCB，有必要开展进一步研究并制定标准化程序。

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引用次数: 0

BiPAP as a Possible Treatment in Patients With Diaphragmatic Flutter 将 BiPAP 作为膈肌扑动患者的一种可能治疗方法。

IF 8.7 3区医学 Q1 RESPIRATORY SYSTEM

Archivos De Bronconeumologia

Pub Date : 2024-11-01 DOI: 10.1016/j.arbres.2024.06.011

引用次数: 0

Identification of Genetic Factors Associated With DAMP Release in COPD Patients 确定慢性阻塞性肺病患者中与 DAMP 释放相关的遗传因素

IF 8.7 3区医学 Q1 RESPIRATORY SYSTEM

Archivos De Bronconeumologia

Pub Date : 2024-11-01 DOI: 10.1016/j.arbres.2024.06.020

引用次数: 0

Increased TGFβ1, VEGF and IFN-γ in the Sputum of Severe Asthma Patients With Bronchiectasis 伴有支气管扩张的严重急性呼吸衰竭患者骨髓中的 TGFβ1、血管内皮生长因子和 IFN-γ 增高

IF 8.7 3区医学 Q1 RESPIRATORY SYSTEM

Archivos De Bronconeumologia

Pub Date : 2024-11-01 DOI: 10.1016/j.arbres.2024.05.036

Background

Bronchiectasis is one of the most common comorbidities in severe asthma. However, the mechanisms by which asthma promotes the development and progress of this condition are not well defined. This study aimed to analyze the inflammatory phenotypes and quantify the expression of proinflammatory and remodeling cytokines in asthma patients with and without bronchiectasis.

Methods

The study sample comprised individuals with severe asthma and bronchiectasis (group AB, n = 55) and a control population of individuals with severe asthma without bronchiectasis (group AC, n = 45). Induced sputum samples were obtained and cell types determined by differential cell count. Proinflammatory and bronchial remodeling cytokines (IL-8, neutrophilic elastase, TGFβ1, VEGF, IFN-γ, TNF-α, and GM-CSF) were analyzed by immunoassay in sputum supernatant.

Results

Neutrophilic inflammation was the primary phenotype in both asthma groups. Higher levels of TGFβ1, VEGF and IFN-γ were observed in asthma patients with bronchiectasis (group AB) than in controls (group AC) (15 vs 24 pg/ml, p = 0.014; 183 vs 272 pg/ml, p = 0.048; 0.85 vs 19 pg/ml, p < 0.001, respectively). Granulocyte-macrophage colony-stimulating factor (GM-CSF) levels were significantly lower in the AB group than in the AC group (1.2 vs 4.4 pg/ml, p < 0.001). IL-8, neutrophil elastase and TNF-α did not present significant differences between the groups.

Conclusions

Raised levels of TGFβ1 and VEGF cytokines may indicate airway remodeling activation in asthma patients with bronchiectasis. The type of inflammation in asthma patients did not differ according to the presence or absence of bronchiectasis.

背景支气管扩张是严重哮喘最常见的并发症之一。然而，哮喘促进该病发生和发展的机制尚未明确。本研究旨在分析有支气管扩张和无支气管扩张的哮喘患者的炎症表型，并量化促炎症细胞因子和重塑细胞因子的表达。采集诱导痰样本并通过细胞计数差法确定细胞类型。通过免疫测定分析痰上清液中的促炎症和支气管重塑细胞因子（IL-8、中性粒细胞弹性蛋白酶、TGFβ1、血管内皮生长因子、IFN-γ、TNF-α 和 GM-CSF）。支气管扩张哮喘患者（AB 组）的 TGFβ1、VEGF 和 IFN-γ 水平高于对照组（AC 组）（分别为 15 vs 24 pg/ml，p = 0.014；183 vs 272 pg/ml，p = 0.048；0.85 vs 19 pg/ml，p < 0.001）。AB组的粒细胞-巨噬细胞集落刺激因子（GM-CSF）水平明显低于AC组（1.2 vs 4.4 pg/ml，p <0.001）。结论TGFβ1和血管内皮生长因子细胞因子水平的升高可能表明支气管扩张哮喘患者的气道重塑被激活。哮喘患者的炎症类型与是否存在支气管扩张并无差异。

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引用次数: 0

Social Determinants of Respiratory Health: Opening the Door 呼吸系统健康的社会决定因素：打开大门

IF 8.7 3区医学 Q1 RESPIRATORY SYSTEM

Archivos De Bronconeumologia

Pub Date : 2024-11-01 DOI: 10.1016/j.arbres.2024.07.022

引用次数: 0

Tracheopleural Fistula: Rare Complication of Pulmonary Tuberculosis 气管胸膜瘘：肺结核的罕见并发症

IF 8.7 3区医学 Q1 RESPIRATORY SYSTEM

Archivos De Bronconeumologia

Pub Date : 2024-11-01 DOI: 10.1016/j.arbres.2024.07.011

引用次数: 0

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