N-3 PUFA supplementation alleviates anxiety symptoms by manipulating erythrocyte fatty acid levels in depression.

IF 4.1 2区 医学 Q2 NUTRITION & DIETETICS European Journal of Nutrition Pub Date : 2024-09-01 Epub Date: 2024-05-17 DOI:10.1007/s00394-024-03421-y
Lu Wang, Ting Liu, Jimin Guo, Tingyu Zhao, Hui Tang, Feifei Wang, Fang Dong, Jindong Chen, Mimi Tang
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Abstract

Purpose: Major depressive disorder (MDD) is frequently accompanied by the symptoms of clinical anxiety. Since our previous research has found that n-3 PUFA supplementation alleviates anxiety in MDD, this study was aimed to further explore whether n-3 PUFA supplementation improves anxiety symptoms in depression by directly manipulating fatty acid levels.

Methods: A secondary analysis of biomarker data (erythrocyte fatty acid composition) collected as part of the randomized clinical trial which investigated the adjunctive effect of n-3 PUFAs was conducted on 72 venlafaxine-treated outpatients with first-diagnosed, drug-naïve depression. All participants with longitudinal biomarker data were included in the association analysis to determine how n-3 PUFA supplementation influences fatty acid composition and alleviates anxiety symptoms in depression.

Results: Decreases of the C20:3n6 were found in all participants at both follow-up time points (χ2 = 96.36, p = 0.000). The n-3 index (χ2 = 10.59, p = 0.001), EPA (χ2 = 24.31, p = 0.000), and C22:5n3/C20:5n3 ratio (χ2 = 10.71, p = 0.001) were increased, while C22:4n6 (χ2 = 7.703, p = 0.006) was decreased in n-3 PUFA group compared to the placebo group. The improvement in anxiety symptoms positively correlates with the extent of reduction of C16:0, C18:0, and total fatty acid levels as well as D5 desaturase activity (p < 0.05).

Conclusion: These data suggest that the anxiolytic effect exerted by n-3 PUFAs in first-diagnosed, drug-naïve depression is manipulated by erythrocyte fatty acid levels. Saturated fatty acid levels have an important role in predicting the severity of anxiety symptoms.

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通过调节抑郁症患者的红细胞脂肪酸水平,补充 N-3 PUFA 可减轻焦虑症状。
目的:重度抑郁症(MDD)经常伴有临床焦虑症状。由于我们之前的研究发现补充 n-3 PUFA 可减轻 MDD 患者的焦虑,因此本研究旨在进一步探讨补充 n-3 PUFA 是否能通过直接调节脂肪酸水平来改善抑郁症患者的焦虑症状:本研究对在研究 n-3 PUFAs 辅助作用的随机临床试验中收集的生物标志物数据(红细胞脂肪酸组成)进行了二次分析,研究对象为 72 名接受过文拉法辛治疗的门诊初诊新药抑郁症患者。所有具有纵向生物标志物数据的参与者都被纳入关联分析,以确定补充 n-3 PUFA 如何影响脂肪酸组成并减轻抑郁症患者的焦虑症状:结果:所有参与者在两个随访时间点均发现 C20:3n6 减少(χ2 = 96.36,p = 0.000)。与安慰剂组相比,n-3 PUFA 组的 n-3 指数(χ2 = 10.59,p = 0.001)、EPA(χ2 = 24.31,p = 0.000)和 C22:5n3/C20:5n3 比率(χ2 = 10.71,p = 0.001)均有所增加,而 C22:4n6 (χ2 = 7.703,p = 0.006)则有所减少。焦虑症状的改善与 C16:0、C18:0 和总脂肪酸水平以及 D5 去饱和酶活性的降低程度呈正相关(p 结论:n-3 PUFA 组与安慰剂组相比,C16:0、C18:0 和总脂肪酸水平以及 D5 去饱和酶活性的降低程度呈正相关:这些数据表明,n-3 PUFAs 对初诊、未服药抑郁症患者的抗焦虑作用受红细胞脂肪酸水平的影响。饱和脂肪酸水平在预测焦虑症状的严重程度方面具有重要作用。
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来源期刊
CiteScore
10.20
自引率
2.00%
发文量
295
审稿时长
6 months
期刊介绍: The European Journal of Nutrition publishes original papers, reviews, and short communications in the nutritional sciences. The manuscripts submitted to the European Journal of Nutrition should have their major focus on the impact of nutrients and non-nutrients on immunology and inflammation, gene expression, metabolism, chronic diseases, or carcinogenesis, or a major focus on epidemiology, including intervention studies with healthy subjects and with patients, biofunctionality of food and food components, or the impact of diet on the environment.
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