European Journal of Nutrition最新文献

Purpose: Our aim was to examine the effects of combined prebiotic fiber supplementation and weight loss counseling on liver fat, body composition, subjective appetite, serum metabolomics, and intestinal microbiota in adults with MASLD.

Methods: In a double blind, placebo-controlled trial, adult participants aged 18-70 years old with MASLD were randomized to receive prebiotic (oligofructose-enriched inulin, 16 g/day; n = 22) or isocaloric placebo (maltodextrin; n = 20) for 24 weeks alongside weight loss counseling from a registered dietitian. Primary outcomes were change in intrahepatic fat % (IHF%) and hepatic injury from baseline to 24 weeks. Secondary outcomes included body composition, subjective appetite, serum lipids and cytokines, fecal microbiota, and serum metabolomics.

Results: At baseline, participants had IHF of 14.4 ± 8.4%. The change in IHF from baseline to 24 weeks did not differ between prebiotic and placebo. Prebiotic participants had a greater decrease (p = 0.029) in percent trunk fat compared to placebo. Compared to placebo, prebiotic significantly decreased desire to eat and hunger ratings over the course of the intervention. Fecal microbiota analysis showed a significant increase in Bifidobacterium abundance with prebiotic. A pathway analysis based on untargeted serum metabolomics revealed a downregulation of taurine and hypotaurine metabolism in the placebo group which was conserved in the prebiotic group.

Conclusion: Adding prebiotic fiber supplementation to weight loss counseling for adults with MASLD enhanced reductions in trunk fat and had a beneficial effect on subjective appetite compared to placebo. Improvements in fecal microbial profile and taurine metabolism revealed specific beneficial effects of prebiotics in the management of MASLD.

Clinical trial registration: Clinicaltrials.gov/study/NCT02568605.

Purpose: Menopause is associated with muscle detriment and physical compromise. However, relevant mechanisms and effective interventions remain elusive. We investigated the therapeutic effects of exogenous butyrate administration on skeletal muscle and physical capacity with relevance to intestinal leak as a potential mechanism in post-menopausal women.

Methods: We recruited post-menopausal women as placebo (age = 55.4 ± 3.3 years, n = 76) and butyrate (age = 54 ± 2.8 years, n = 70) groups, along with pre-menopausal women (age = 42.3 ± 3 years, n = 75) as controls. The butyrate group received sodium butyrate (570 mg capsules) daily for 12 weeks. We measured plasma biomarkers of intestinal leak (zonulin) and sepsis (lipopolysaccharide-binding protein, LBP) along with handgrip strength (HGS), gait speed, and physical performance (short physical performance battery, SPPB).

Results: Post-menopausal women had higher zonulin and LBP and lower HGS, gait speed, and SPPB scores than pre-menopausal women (all p < 0.05). Butyrate reduced plasma zonulin and LBP levels and improved HGS and SPPB scores in post-menopausal women (all p < 0.05). We found significant correlations of reduction in plasma zonulin and LBP with improvement in HGS and SPPB in the butyrate group (all p < 0.05). Butyrate also modestly improved respiratory muscle strength and reduced systemic inflammation and oxidative stress in post-menopausal women (all p < 0.05).

Conclusion: Collectively, our findings demonstrate the muscle-protective effects of butyrate through intestinal mucosal repair. Future research is warranted to elucidate the underlying mechanisms of butyrate in post-menopausal women.

Purpose: Postprandial glycaemic control is critical for diabetes prevention and management. Various dietary strategies have been explored to modulate postprandial glycaemia, with the inclusion of innovative fibres showing promising benefits in reducing daily glycaemic load and improving overall glycaemic control.

Methods: In this study, we conducted an 8-week, randomised, controlled, parallel-arm trial involving 78 healthy adults living in Singapore (average age: 39.9 ± 10.6 years; 48 men and 30 women), who were divided into two subgroups: the overweight group (OG) and the genetic risk group (GRG).

Results: Daily supplementation with 40 g of NUTRIOSE^® soluble fibre significantly improved 24 h glucose homeostasis under free-living conditions. Compared to the postprandial glycaemic response after breakfast and lunch, NUTRIOSE^® supplementation for 8 weeks resulted in a more substantial improvement in the glycaemic response after dinner. Furthermore, one day of NUTRIOSE^® supplementation led to improved glucose management in both participant subgroups, with more significant improvements observed in the OG group compared to the GRG. However, a reduction in appetite following NUTRIOSE^® supplementation was mostly observed in the GRG. Additionally, NUTRIOSE^® consumption led to a decrease in PBFtrunk% and an increase in FFMtrunk in female participants in the GRG.

Conclusion: Incorporating innovative fibres can serve as an effective dietary strategy to lower daily glycaemic load and enhance glycaemic control, offering significant public health benefits and encouraging the consumption of resistant dextrin. However, further investigation into the role of chrono-nutrition is warranted, as it plays a key role in understanding glucose homeostasis throughout the day.

Purpose: According to a WHO statement, it has been asserted that there is no safe level of alcohol consumption regarding human health. Nevertheless, the relationship between alcohol consumption and Alzheimer's disease (AD) pathology remains unclear. Therefore, we examined whether the frequency and patterns of alcohol consumption could predict neurodegeneration biomarkers in a cohort of middle-aged adults without dementia.

Methods: A total of 195 participants without dementia were included from the ALBION study. Multivariate logistic regression analyses were conducted using drinking frequency subgroups (abstainers, occasional drinkers, and light-to-moderate drinkers) and Mediterranean-Alcohol Dietary Pattern (MADP) adherence subgroups along with cerebrospinal fluid (CSF) AD biomarkers (Tau, phosphorylated tau (PTau) and amyloid beta (Aβ). In these analyses, the abstinence was used as the reference category.

Results: Of the 195 individuals without dementia, 66% were female, with an average age of 65 ± 9.4 years, and they had 13.8 ± 3.6 years of education. Logistic regression analyses revealed that light-to-moderate drinkers (n = 51) were associated with higher Aβ positivity [OR: 2.98 (1.29-6.90)] compared to the abstinence (n = 117). Additionally, high adherence to the MADP was significantly associated with higher Aβ, Tau/Aβ_42, and PTau/Aβ₄₂ ratios positivity compared to the abstinence.

Conclusion: Light-to-moderate alcohol intake was associated with higher Aβ deposition in middle-aged individuals without dementia, compared to abstinence. High adherence to the MADP, which indicates low-to-moderate red wine consumption distributing over the week with meals, was associated with a higher Aβ and Tau/Aβ and PTau/Aβ positivity. Therefore, the management of alcohol consumption may help improve AD outcomes even at the preclinical stage.

Purpose: Insulin resistance (IR) is an important mediator of the relationship between food intake and the development of type 2 diabetes mellitus (T2DM). Most of the few studies that have evaluated this relationship relied on the triglyceride-glucose index (TyG index) tool. Here, we evaluated the association between leucine intake, glycemic index, and T2DM with related mediators in individuals throughout secondary cardiovascular prevention.

Methods: Sociodemographic, anthropometric, clinical, and food intake data were recorded from the baseline of the trial Brazilian Cardioprotective Nutritional (BALANCE) Program. Path analysis was used to explore the relationships between variables.

Results: This study enrolled 2,247 participants (median age of 63.0 (45-91) years; 58.8% males). The TyG index showed positive association with T2DM (SC = 0.356; p < 0.001) and negative association with leucine intake (SC= -0.046; p = 0.028). The glycemic index (GI) was positively associated with BMI (SC = 0.072; p = 0.001), and BMI had an indirect positive effect on T2DM mediated by the TyG index (SC = 0.078; p < 0.001). Leucine intake had indirect negative effect on T2DM, mediated by the TyG index (SC= -0.016; p = 0.029), while GI had indirect positive effect on T2DM mediated by BMI and TyG index (SC = 0.006; p = 0.002).

Conclusion: Leucine intake and GI showed indirect association with T2DM, mediated by TyG and BMI, in individuals on secondary cardiology prevention, reinforcing the importance of assessing food consumption and promotin food quality improvements for cardiometabolic control by different pathways. TRIAL REGISTRATION CLINICALTRIALS.

Gov identifier: NCT01620398. Registered 15 June 2012.

Purpose: Diets high in pulses and legumes have been associated with improved cardiovascular disease (CVD) risk markers but the relationship is less well studied in UK populations. To address this, associations between consumption of pulses (dried beans, peas and lentils) and legumes (pulses, fresh peas and green beans) with nutrient intake and status, a sustainable diet quality score (EAT-Lancet index), CVD risk markers and food expenditure was assessed in representative UK populations.

Methods: A secondary analysis of data from the UK National Diet and Nutrition Survey (2008-2019) and the Living Costs and Food Survey (2001-2022) was conducted. To assess the relationships, regression models controlling for covariates were used.

Results: Children and adults consumed mean ± SD 10.6 ± 27.0 g/day and 15.0 ± 21.0 g/day of pulses, and 16.7 ± 32.5 g/day and 27.3 ± 26.0 g/day of legumes, respectively. Diets rich in pulses and legumes were associated with higher intakes of energy, fibre, vitamin E, thiamine, folate, biotin, sodium, potassium, phosphorus, magnesium, iron, zinc, and manganese; lower intakes of saturated fats, total and free sugars and higher plasma selenium and total carotenoid concentrations (all P < 0.05). Consumption of a portion (80 g) of pulses and legumes was associated with a 3.7 point increase in EAT-Lancet index (P < 0.001). Average expenditure on pulses and legumes/person/week in 2022 was £1.68 and £2.90, equivalent to 0.33% and 0.56% of weekly income respectively.

Conclusions: Pulse and legume-rich diets are broadly associated with a more optimum nutrient intake, higher micronutrient status and a more sustainable diet. Strategies are needed to increase pulse and legume consumption in UK populations.

Objective: This randomized, double-blind, parallel-group clinical trial aimed to evaluate the efficacy of Black Cohosh, Soy Isoflavones, and SDG Lignans in alleviating menopausal symptoms compared to a placebo.

Methods: Ninety-six postmenopausal women aged 45-60 years were enrolled. Participants were randomized to receive either the study supplements or a placebo for 90 days, with Menopause Rating Scale (MRS) scores collected at baseline and every 4 weeks to monitor symptom changes. Secondary outcomes assessed included hormonal variations and the incidence of adverse symptoms.

Results: Of the initial cohort, 90 participants completed the study with high adherence. Significant improvements were observed in the treatment group across all MRS domains: somatic (- 54.3% difference, p < 0.01), psychological (- 54.3% difference, p < 0.01), urogenital (-37.3% difference, p < 0.01), and total score (- 48.0% difference, p < 0.01). Hormonal changes were modest yet statistically significant for FSH (- 6.7% difference, p < 0.01) and estradiol (12.6% difference, p < 0.01). Adverse events were minimal, transient, and did not require cessation of supplementation.

Conclusion: Black Cohosh, Soy Isoflavones, and SDG Lignans significantly reduced menopausal symptoms with a favorable safety profile. These findings support the potential of this supplement combination as a therapeutic option for menopausal symptom management.

Trial registration: ClinicalTrials.gov NCT06328348.

Purpose: We aimed to quantify urinary excretion of LNCS (Low- and No-Calorie Sweeteners) and to identify LNCS-associated food consumption in Germany, with special emphasis on exposure to combinations of different LNCS.

Methods: UPLC-MS/MS was used to quantify LNCS metabolites in 24-hour urine samples of 301 participants from the cross-sectional KarMeN (Karlsruhe Metabolomics and Nutrition) study. Dietary data were assessed via 24 h recall. Spearman rank correlation analysis and multiple linear regression models were used to investigate food groups that contribute to LNCS exposure.

Results: Based on the number of samples with quantifiable urinary concentrations and the absolute excretion within a day, cyclamate (88% of samples), saccharin (44%), acesulfame (35%), and aspartame (32%) were most commonly consumed. The consumption of specific food groups, such as table sweeteners, light soft drinks, Radler, protein shakes, and stevia sweeteners, accounted for significant variations in urinary concentrations. Specific combinations of LNCS were observed for these food groups, as well as a considerable exploitation of LNCS-specific ADI (acceptable daily intake).

Conclusion: Individuals who consume high amounts of specific LNCS-containing, processed foods are exposed to a notable mix of various LNCS. Since data on associations between mixed LNCS exposure and health are lacking, it is an urgent issue to evaluate the potential risks of consuming combinations of diverse LNCS rather than conducting risk assessments of single LNCS.

Background: To strengthen the scientific evidence linking dietary sugar consumption with health outcomes, it's essential to look beyond the usual focus on non-communicable diseases (NCDs) and tooth decay. We thus hypothesize that considering other dimensions of health beyond physical health will meaningfully complement the evidence and expand our understanding of the relationship between nutrition and health.

Purpose: The aim of this scoping review was to explore the scientific evidence of an association between dietary sugar intake and quality of life (QoL) among healthy children and adolescents.

Methods: We performed a literature search in three databases (i.e., PubMed, Scopus, and Web of Science). The search included all types of studies assessing dietary sugar intake in association with QoL, in children and adolescents published in English between January 2001 and January 2023.

Results: Twenty-one full-text eligible papers were included in this review: one intervention, two prospective cohort studies, and 18 cross-sectional studies. The number of participants ranged from 25 to 65,000 and age of the participants ranged from 4 to 19 years. The studies differed considerably in exposure and outcome measures. For further qualitative analyses, the studies were categorized into studies related to different dimensions of QoL: food security (n = 4), sleep-related outcomes (n = 5), oral (n = 3) and (mental) health-related QoL (n = 9). Altogether, one study reported a null while the remaining 20 studies found adverse associations between intake of sugar, sugar-sweetened beverages (SSB), or sweets and outcome measures of QoL.

Conclusion: Through this scoping review, a number of scientific studies have revealed an association between sugar intake among children and adolescents and health-related QoL. The findings underscore a negative association. Our review emphasizes the crucial imperative of embracing a broader spectrum of health dimensions to gain a more wholistic understanding of nutrition, especially in collecting science-based evidence for the development of health policies, including dietary guidelines.