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Association between dietary inflammatory potential and cognitive performance in children. 儿童饮食炎症潜能与认知能力的关系。
IF 4.3 2区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2026-02-07 DOI: 10.1007/s00394-026-03892-1
Chong-Su Kim
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引用次数: 0
Relationships between consumption of theobromine in cocoa products and cardiovascular risk factors in 2015-2020 National health and nutrition examination survey. 2015-2020年全国健康与营养调查中可可制品中可可碱摄入量与心血管危险因素的关系
IF 4.3 2区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2026-02-03 DOI: 10.1007/s00394-026-03893-0
Witchuda Ponsuporn, Nenad Naumovski, Andrew J McKune, Julaluk Khemacheewakul, Noppol Leksawasdi, Pornchai Rachtanapun, Siraphat Taesuwan

Purpose: Cocoa is a significant source of theobromine, a bioactive compound proposed to provide cardiovascular protection. However, relatively few studies have provided conclusive evidence of the potential beneficial health effects. The aim of this study was to determine the relationship between the consumption of cocoa products containing theobromine and cardiovascular risk factors in the U.S. population sample using 2015-2020 National Health and Nutrition Examination Survey (NHANES) data.

Method: This cross-sectional study included 8531 individuals aged 20-70 years and 3808 people in a fasting sub-sample. Theobromine and cocoa product intake levels were obtained from 24-h dietary recalls and linked to the Food and Nutrient Database for Dietary Studies database. Primary outcomes included systolic and diastolic blood pressure, hypertension, serum total, HDL and LDL cholesterol, triglyceride, glycohemoglobin, insulin, plasma glucose, and high-sensitivity C-reactive protein (hs-CRP). Linear regression models were applied to analyze the associations between theobromine or cocoa product consumption and cardiovascular risk factors.

Results: The consumption of cocoa was not associated with cardiovascular disease risk factors compared to non-consumption. The amounts of cocoa consumed were inversely associated with glycohemoglobin levels (mean ± SE, - 0.04 ± 0.02% per 100 g, P = 0.04). Theobromine intake (vs. no intake) was positively associated with serum insulin (1.85 ± 0.85 μU/mL; P = 0.03). Theobromine levels consumed were inversely associated with glycohemoglobin (- 0.05 ± 0.03% per 100 mg, P = 0.04), serum triglycerides (- 5.4 ± 2.73 mg/dL, P = 0.05), and hs-CRP levels (- 0.26 ± 0.12 mg/L, P = 0.04). These associations were also mostly observed in people with healthier profiles.

Conclusion: Increased cocoa consumption is associated with reduced glycohemoglobin levels, while higher theobromine intake is associated with reduced triglyceride, glycohemoglobin, and hs-CRP levels compared to a lower intake. The positive link between theobromine intake, as opposed to no intake, and serum insulin required further investigation. Overall findings support the inclusion of cocoa-derived compounds in healthy diets.

目的:可可是可可碱的重要来源,可可碱是一种生物活性化合物,可提供心血管保护。然而,相对较少的研究提供了潜在有益健康影响的确凿证据。本研究的目的是利用2015-2020年国家健康与营养检查调查(NHANES)的数据,确定美国人口样本中含有可可碱的可可制品的消费与心血管风险因素之间的关系。方法:这项横断面研究包括8531名20-70岁的个体和3808名空腹亚样本。可可碱和可可制品的摄入水平从24小时的饮食召回中获得,并与饮食研究的食品和营养数据库相关联。主要结局包括收缩压和舒张压、高血压、血清总胆固醇、HDL和LDL胆固醇、甘油三酯、糖蛋白、胰岛素、血糖和高敏c反应蛋白(hs-CRP)。线性回归模型用于分析可可碱或可可制品消费与心血管危险因素之间的关系。结果:与不食用可可相比,食用可可与心血管疾病风险因素无关。可可摄入量与糖蛋白水平呈负相关(平均±SE, - 0.04±0.02% / 100 g, P = 0.04)。可可碱摄入量与血清胰岛素呈正相关(1.85±0.85 μU/mL; P = 0.03)。可可碱消耗水平与糖蛋白(- 0.05±0.03% / 100 mg, P = 0.04)、血清甘油三酯(- 5.4±2.73 mg/dL, P = 0.05)和hs-CRP水平(- 0.26±0.12 mg/L, P = 0.04)呈负相关。这些关联也主要在健康状况较好的人群中观察到。结论:可可摄入量的增加与糖蛋白水平的降低有关,而可可碱摄入量的增加与甘油三酯、糖蛋白和hs-CRP水平的降低有关。与不摄入可可碱相比,摄入可可碱与血清胰岛素之间的正相关关系需要进一步研究。总的来说,研究结果支持将可可衍生化合物纳入健康饮食。
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引用次数: 0
Modulation of inflammasome components in patients with heart failure using oral nutritional supplements: investigating the molecular mechanisms beyond the clinical benefit. 使用口服营养补充剂对心衰患者炎症小体成分的调节:研究临床益处之外的分子机制。
IF 4.3 2区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2026-02-03 DOI: 10.1007/s00394-025-03878-5
Aura D Herrera-Martínez, Natalia Hermán-Sánchez, Miguel E G-García, Concepción Muñoz-Jiménez, Jesús M Pérez-Gómez, Antonio J Montero-Hidalgo, José López-Aguilera, Rafael González-Manzanares, María Ángeles Gálvez-Moreno, María José Molina-Puerta, Raúl M Luque
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引用次数: 0
Adherence to a paleolithic diet and paleolithic-like lifestyle is associated with lower colorectal cancer risk. 坚持旧石器时代的饮食和旧石器时代的生活方式与降低结直肠癌的风险有关。
IF 4.3 2区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2026-01-27 DOI: 10.1007/s00394-025-03887-4
Mian-Mian Jiang, Qing-Jian Ou, Yu-Jing Fang, Fang-Ting Lin, Ke-Xin Tu, Cai-Xia Zhang
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引用次数: 0
Harnessing generalized structural equation modelling to understand the pathway linking maternal and child factors to fruit and vegetable intake trajectories from toddlerhood to adolescence. 利用广义结构方程模型来理解从幼儿期到青春期的水果和蔬菜摄入轨迹与母婴因素之间的联系。
IF 4.3 2区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2026-01-24 DOI: 10.1007/s00394-025-03883-8
Miaobing Zheng, Jia Ying Toh, Mya Thway Tint, Geeta Appannah, Wei Wei Pang, Keith M Godfrey, Yap-Seng Chong, Yung Seng Lee, Fabian Yap, Johan G Eriksson, Mary F F Chong
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引用次数: 0
Vitamin D status and type 2 diabetes incidence in Finnish adults-a longitudinal survey and register-based study using standardized serum 25-hydroxyvitamin D data. 芬兰成年人维生素D状况和2型糖尿病发病率——一项使用标准化血清25-羟基维生素D数据的纵向调查和基于登记的研究
IF 4.3 2区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2026-01-24 DOI: 10.1007/s00394-025-03889-2
Folasade A Adebayo, Suvi T Itkonen, Tuija Jääskeläinen, Tommi Härkänen, Kevin D Cashman, Maijaliisa Erkkola, Christel Lamberg-Allardt
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引用次数: 0
Sugar- and artificially sweetened beverages consumption, body weight, and eating disorders symptoms: findings from a Danish cohort from childhood to early adulthood. 糖和人工加糖饮料的摄入、体重和饮食失调症状:来自丹麦儿童至成年早期队列的研究结果
IF 4.3 2区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2026-01-20 DOI: 10.1007/s00394-025-03869-6
Cristina Valle-Hita, Andrea Joensen, Anne Ahrendt Bjerregaard, Nancy Babio, Katrine Strandberg-Larsen, Marta Guasch-Ferré
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引用次数: 0
Impact of habitual seaweed consumption on iodine nutrition and thyroid function: a non-randomized pre-post clinical study. 习惯性食用海藻对碘营养和甲状腺功能的影响:一项非随机的临床前后研究。
IF 4.3 2区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2026-01-16 DOI: 10.1007/s00394-025-03813-8
Inger Aakre, Elinor Chelsom Vogt, Lene S Myrmel, Anne-Katrine Lundebye, Olivia Bysheim Helland, Sigrun Henjum, Lisbeth Dahl, Maria Wik Markhus, Synnøve Næss Sleire, Silje Jotun Løkken, Hanne Rosendahl-Riise
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引用次数: 0
Global burden of dietary-related mortality in working-age population, 1990-2021: trends and disparities across 204 countries and territories. 1990-2021年全球工作年龄人口饮食相关死亡率负担:204个国家和地区的趋势和差异
IF 4.3 2区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2026-01-16 DOI: 10.1007/s00394-025-03881-w
Xiao-Lu Lin, Yi-Ming Song, Xiao-Jie Huang, Qing-Wei Zhang, Shi-Jie Yang, Liu-Yi Yang, Zhao Li, Gui-Fen Chen, Ze-Yu Li, Qing-Ran Liu, Zhong-Ge Ji, Si-Jia Zhai, Rui-Tian Zeng, Yu-Fei Xiao, Rui-Jie Han, Yu-Xin Yang, Jing-Jing Chen, Wei Liang, Xiao-Bo Li, Wan-Yin Deng
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引用次数: 0
Development and evaluation of a nutrient-derived anti-inflammatory dietary index (NADI) among Chinese adults. 中国成人营养源性抗炎膳食指数(NADI)的建立与评价
IF 4.3 2区 医学 Q2 NUTRITION & DIETETICS Pub Date : 2026-01-16 DOI: 10.1007/s00394-025-03879-4
Yuxiang Yang, Shuya Cai, Tamas Szili-Torok, Wei Piao, Kun Huang, Changyuan Yang, Huifang Xue, Jing Nan, Fusheng Li, Dongmei Yu, Changzheng Yuan, Martin H de Borst

Purpose: To develop and evaluate an anti-inflammatory dietary index based on the specific dietary culture and preference among Chinese adults.

Methods: A total of 6322 participants were included and were further separated into a training (n = 4514) and a validation set (n = 1808). In the training set, we utilized reduced rank regression to derive a dietary index based on the intake of 33 food groups and five pre-identified anti-inflammatory nutrients. In the validation set, interleukin (IL)-1β, IL-4, IL-6, and high-sensitivity C-reactive protein (hs-CRP) were measured, and a total inflammation score (TIS) was constructed. Pearson partial correlation analysis and multivariate generalized linear regression were applied to explore the relationship between dietary indices and inflammatory biomarkers.

Results: The derived dietary index, termed Nutrient-derived Anti-inflammatory Dietary Index (NADI), mainly characterized by a higher intake of fresh vegetables and fruits, mushrooms and fungi, soybeans, fresh eggs, and tea, alongside a lower intake of red meat, alcohol, and refined grains. NADI significantly correlated with several well-established dietary indices. Participants in the highest quintile of NADI had lower plasma levels of IL-1β (relative concentration [RC]: 0.67, 95% CI 0.58 ~ 0.77), hs-CRP (RC: 0.68, 95% CI 0.58 ~ 0.80), and TIS (RC: 0.43, 95% CI 0.31 ~ 0.59) compared with the lowest quintile in the fully adjusted model. Results were similar in subgroups and sensitivity analyses.

Conclusions: NADI effectively captures inflammation-related dietary quality and could serve as a valuable instrument for evaluating the impact of dietary inflammatory potential on health outcomes in Chinese adults.

目的:根据中国成年人特定的饮食文化和偏好,建立并评价抗炎饮食指数。方法:共纳入6322名受试者,并将其进一步分为训练组(n = 4514)和验证组(n = 1808)。在训练集中,我们使用降阶回归来获得基于33种食物组和5种预先确定的抗炎营养素摄入量的饮食指数。在验证组中,检测白细胞介素(IL)-1β、IL-4、IL-6和高敏c反应蛋白(hs-CRP),并构建总炎症评分(TIS)。应用Pearson偏相关分析和多元广义线性回归探讨饮食指标与炎症生物标志物之间的关系。结果:衍生饮食指数,称为营养衍生抗炎饮食指数(NADI),主要特征是摄入更多的新鲜蔬菜和水果、蘑菇和真菌、大豆、新鲜鸡蛋和茶,同时摄入更少的红肉、酒精和精制谷物。NADI与几个已确立的膳食指标显著相关。NADI最高五分位数的受试者血浆IL-1β水平(相对浓度[RC]: 0.67, 95% CI 0.58 ~ 0.77)、hs-CRP (RC: 0.68, 95% CI 0.58 ~ 0.80)和TIS (RC: 0.43, 95% CI 0.31 ~ 0.59)均低于完全调整模型中最低五分位数的受试者。亚组和敏感性分析结果相似。结论:NADI可有效捕获与炎症相关的饮食质量,并可作为评估中国成年人饮食炎症潜力对健康结果影响的有价值工具。
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European Journal of Nutrition
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