{"title":"Secofumitremorgins C and D, a pair of atropisomers from saltern-derived fungus Aspergillus fumigatus GXIMD00544","authors":"","doi":"10.1080/10286020.2024.2349664","DOIUrl":null,"url":null,"abstract":"<div><p>A pair of atropisomers secofumitremorgins C (<strong>1a</strong>) and D (<strong>1b</strong>), together with fifteen known alkaloids (<strong>2-16</strong>), were isolated from a saltern-derived fungus <em>Aspergillus fumigatus</em> GXIMD00544. The structures of atropisomers <strong>1a</strong> and <strong>1b</strong> were elucidated by the detailed spectroscopic data, chemical reaction and quantum chemical calculations. Compounds <strong>1</strong> and <strong>8</strong> displayed antifungal spore germination effects against plant pathogenic fungus associated with sugarcane <em>Fusarium</em> sp. with inhibitory rates of 53% and 77% at the concentration of 100 µM, repectively. Atropisomers <strong>1</strong> also exhibited antifouling potential against <em>Balanus amphitrite</em> larval settlement with an inhibitory rate of 96% at the concentration of 100 µM.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 9","pages":"Pages 1049-1056"},"PeriodicalIF":1.3000,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1028602024000687","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
A pair of atropisomers secofumitremorgins C (1a) and D (1b), together with fifteen known alkaloids (2-16), were isolated from a saltern-derived fungus Aspergillus fumigatus GXIMD00544. The structures of atropisomers 1a and 1b were elucidated by the detailed spectroscopic data, chemical reaction and quantum chemical calculations. Compounds 1 and 8 displayed antifungal spore germination effects against plant pathogenic fungus associated with sugarcane Fusarium sp. with inhibitory rates of 53% and 77% at the concentration of 100 µM, repectively. Atropisomers 1 also exhibited antifouling potential against Balanus amphitrite larval settlement with an inhibitory rate of 96% at the concentration of 100 µM.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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