Natural products in the management of neurodegenerative diseases.

IF 3.9 2区医学 Q2 NUTRITION & DIETETICS Nutrition & Metabolism Pub Date : 2024-05-16 DOI:10.1186/s12986-024-00800-4

Rajat Goyal, Pooja Mittal, Rupesh K Gautam, Mohammad Amjad Kamal, Asma Perveen, Vandana Garg, Athanasios Alexiou, Muhammad Saboor, Shafiul Haque, Aisha Farhana, Marios Papadakis, Ghulam Md Ashraf

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Abstract

Neurodegenerative diseases represent one of the utmost imperative well-being health issues and apprehensions due to their escalating incidence of mortality. Natural derivatives are more efficacious in various preclinical models of neurodegenerative illnesses. These natural compounds include phytoconstituents in herbs, vegetables, fruits, nuts, and marine and freshwater flora, with remarkable efficacy in mitigating neurodegeneration and enhancing cognitive abilities in preclinical models. According to the latest research, the therapeutic activity of natural substances can be increased by adding phytoconstituents in nanocarriers such as nanoparticles, nanogels, and nanostructured lipid carriers. They can enhance the stability and specificity of the bioactive compounds to a more considerable extent. Nanotechnology can also provide targeting, enhancing their specificity to the respective site of action. In light of these findings, this article discusses the biological and therapeutic potential of natural products and their bioactive derivatives to exert neuroprotective effects and some clinical studies assessing their translational potential to treat neurodegenerative disorders.

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治疗神经退行性疾病的天然产品。

神经退行性疾病是最紧迫的健康问题之一，其死亡率不断攀升，令人担忧。天然衍生物在神经退行性疾病的各种临床前模型中更具疗效。这些天然化合物包括草药、蔬菜、水果、坚果以及海洋和淡水菌群中的植物成分，在临床前模型中对减轻神经退行性病变和提高认知能力具有显著疗效。根据最新研究，在纳米载体（如纳米颗粒、纳米凝胶和纳米结构脂质载体）中添加植物成分可提高天然物质的治疗活性。它们可以在更大程度上提高生物活性化合物的稳定性和特异性。纳米技术还可以提供靶向性，提高其对相应作用部位的特异性。鉴于这些发现，本文讨论了天然产品及其生物活性衍生物发挥神经保护作用的生物和治疗潜力，以及一些评估其治疗神经退行性疾病转化潜力的临床研究。

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来源期刊

Nutrition & Metabolism 医学-营养学

CiteScore

8.40

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition & Metabolism publishes studies with a clear focus on nutrition and metabolism with applications ranging from nutrition needs, exercise physiology, clinical and population studies, as well as the underlying mechanisms in these aspects. The areas of interest for Nutrition & Metabolism encompass studies in molecular nutrition in the context of obesity, diabetes, lipedemias, metabolic syndrome and exercise physiology. Manuscripts related to molecular, cellular and human metabolism, nutrient sensing and nutrient–gene interactions are also in interest, as are submissions that have employed new and innovative strategies like metabolomics/lipidomics or other omic-based biomarkers to predict nutritional status and metabolic diseases. Key areas we wish to encourage submissions from include: -how diet and specific nutrients interact with genes, proteins or metabolites to influence metabolic phenotypes and disease outcomes; -the role of epigenetic factors and the microbiome in the pathogenesis of metabolic diseases and their influence on metabolic responses to diet and food components; -how diet and other environmental factors affect epigenetics and microbiota; the extent to which genetic and nongenetic factors modify personal metabolic responses to diet and food compositions and the mechanisms involved; -how specific biologic networks and nutrient sensing mechanisms attribute to metabolic variability.