Chromatic visual evoked potentials: A review of physiology, methods and clinical applications.

IF 18.6 1区 医学 Q1 OPHTHALMOLOGY Progress in Retinal and Eye Research Pub Date : 2024-07-01 Epub Date: 2024-05-16 DOI:10.1016/j.preteyeres.2024.101272
Oliver R Marmoy, Manca Tekavčič Pompe, Jan Kremers
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Abstract

Objective assessment of the visual system can be performed electrophysiologically using the visual evoked potential (VEP). In many clinical circumstances, this is performed using high contrast achromatic patterns or diffuse flash stimuli. These methods are clinically valuable but they may only assess a subset of possible physiological circuitries within the visual system, particularly those involved in achromatic (luminance) processing. The use of chromatic VEPs (cVEPs) in addition to standard VEPs can inform us of the function or dysfunction of chromatic pathways. The chromatic VEP has been well studied in human health and disease. Yet, to date our knowledge of their underlying mechanisms and applications remains limited. This likely reflects a heterogeneity in the methodology, analysis and conclusions of different works, which leads to ambiguity in their clinical use. This review sought to identify the primary methodologies employed for recording cVEPs. Furthermore cVEP maturation and application in understanding the function of the chromatic system under healthy and diseased conditions are reviewed. We first briefly describe the physiology of normal colour vision, before describing the methodologies and historical developments which have led to our understanding of cVEPs. We thereafter describe the expected maturation of the cVEP, followed by reviewing their application in several disorders: congenital colour vision deficiencies, retinal disease, glaucoma, optic nerve and neurological disorders, diabetes, amblyopia and dyslexia. We finalise the review with recommendations for testing and future directions.

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色觉视觉诱发电位:生理学、方法和临床应用综述。
对视觉系统的客观评估可通过视觉诱发电位(VEP)进行电生理分析。在许多临床情况下,都是使用高对比度消色差模式或漫反射闪光刺激进行评估。这些方法在临床上很有价值,但它们可能只能评估视觉系统中可能存在的生理回路的一部分,尤其是那些参与消色差(亮度)处理的回路。除了标准 VEPs 之外,使用色度 VEPs(cVEPs)可以让我们了解色度通路的功能或功能障碍。色度 VEP 在人类健康和疾病中的应用已得到深入研究。然而,迄今为止,我们对其基本机制和应用的了解仍然有限。这可能反映出不同研究的方法、分析和结论存在差异,从而导致其临床应用的不确定性。本综述旨在确定记录 cVEPs 的主要方法。此外,还回顾了 cVEP 的成熟和应用,以了解健康和疾病条件下色觉系统的功能。我们首先简要介绍了正常色觉的生理学,然后描述了导致我们了解 cVEPs 的方法和历史发展。随后,我们描述了 cVEP 的预期成熟过程,并回顾了它们在以下几种疾病中的应用:先天性色觉缺陷、视网膜疾病、青光眼、视神经和神经系统疾病、糖尿病、弱视和阅读障碍。最后,我们对测试和未来发展方向提出了建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
34.10
自引率
5.10%
发文量
78
期刊介绍: Progress in Retinal and Eye Research is a Reviews-only journal. By invitation, leading experts write on basic and clinical aspects of the eye in a style appealing to molecular biologists, neuroscientists and physiologists, as well as to vision researchers and ophthalmologists. The journal covers all aspects of eye research, including topics pertaining to the retina and pigment epithelial layer, cornea, tears, lacrimal glands, aqueous humour, iris, ciliary body, trabeculum, lens, vitreous humour and diseases such as dry-eye, inflammation, keratoconus, corneal dystrophy, glaucoma and cataract.
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