Hyperbaric oxygen therapy: future prospects in regenerative therapy and anti-aging.

IF 3.3 Q2 GERIATRICS & GERONTOLOGY Frontiers in aging Pub Date : 2024-05-02 eCollection Date: 2024-01-01 DOI:10.3389/fragi.2024.1368982
Manoj Gupta, Jaishriram Rathored
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Abstract

Hyperbaric Oxygen Therapy (HBOT) utilizes 100% oxygen at high atmospheric pressure for clinical applications. HBOT has proven to be an effective supplementary treatment for a variety of clinical and pathological disorders. HBOT's therapeutic results are based on the physiological effects of increased tissue oxygenation, or improved oxygen bioavailability. HBOT's current indications in illnesses like as wound healing, thermal or radiation burns, and tissue necrosis point to its function in facilitating the regeneration process. Various research has revealed that HBOT plays a function in vascularization, angiogenesis, and collagen production augmentation. Individual regeneration capacity is influenced by both environmental and genetic factors. Furthermore, the regenerating ability of different types of tissues varies, and this ability declines with age. HBOT affects physiological processes at the genetic level by altering gene expression, delaying cell senescence, and assisting in telomere length enhancement. The positive results in a variety of indications, ranging from tissue regeneration to better cognitive function, indicate that it has enormous potential in regenerative and anti-aging therapy.

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高压氧疗法:再生疗法和抗衰老的未来前景。
高压氧疗法(HBOT)在临床应用中使用高气压下的 100% 氧气。事实证明,高压氧疗法是治疗各种临床和病理疾病的有效辅助疗法。HBOT 的治疗效果基于增加组织氧合或改善氧气生物利用率的生理效应。HBOT 目前在伤口愈合、热烧伤或辐射烧伤以及组织坏死等疾病中的适应症表明,它具有促进再生过程的功能。多项研究表明,HBOT 在血管形成、血管生成和胶原蛋白增生方面发挥着作用。个人的再生能力受环境和遗传因素的影响。此外,不同类型组织的再生能力也各不相同,而且这种能力会随着年龄的增长而下降。HBOT 通过改变基因表达、延缓细胞衰老和增加端粒长度来影响基因水平的生理过程。从组织再生到改善认知功能等各种适应症的积极结果表明,它在再生和抗衰老治疗方面具有巨大的潜力。
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CiteScore
3.00
自引率
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0
审稿时长
13 weeks
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