Pub Date : 2024-08-23eCollection Date: 2024-01-01DOI: 10.3389/fragi.2024.1444527
Daniela Frasca, Valquiria Bueno
In this paper, we measured B cell function in elderly healthy individuals (EH) and in elderly patients with Type-2 Diabetes Mellitus (T2DM, ET2DM), which are treatment-naive, as compared to healthy young (YH) individuals. Results show a higher serum inflammatory status of elderly versus young individuals, and especially of ET2DM versus EH. This status is associated with a reduced response to the seasonal influenza vaccine and with increased frequencies of the circulating pro-inflammatory B cell subset called Double Negative (DN) B cells. B cells from ET2DM patients are not only more inflammatory but also hyper-metabolic as compared to those from EH controls. The results herein are to our knowledge the first to show that T2DM superimposed on aging further increases systemic and B cell intrinsic inflammation, as well as dysfunctional humoral immunity. Our findings confirm and extend our previously published findings showing that inflammatory B cells are metabolically supported.
在本文中,我们测量了老年健康人(EH)和未接受治疗的老年 2 型糖尿病(T2DM,ET2DM)患者与健康年轻人(YH)相比的 B 细胞功能。结果显示,老年人的血清炎症状态高于年轻人,尤其是 ET2DM 患者的血清炎症状态高于 EH 患者。这种状态与对季节性流感疫苗的反应减弱以及循环中被称为双阴性(DN)B 细胞的促炎症 B 细胞亚群的频率增加有关。与 EH 对照组相比,ET2DM 患者的 B 细胞不仅更具炎症性,而且代谢也更旺盛。据我们所知,本文的研究结果首次表明,T2DM 与衰老叠加会进一步加剧全身和 B 细胞的内在炎症以及体液免疫功能失调。我们的研究结果证实并扩展了我们之前发表的研究结果,这些结果表明炎症性 B 细胞得到了新陈代谢的支持。
{"title":"Enhanced mitochondrial function in B cells from elderly type-2 diabetes mellitus patients supports intrinsic inflammation.","authors":"Daniela Frasca, Valquiria Bueno","doi":"10.3389/fragi.2024.1444527","DOIUrl":"https://doi.org/10.3389/fragi.2024.1444527","url":null,"abstract":"<p><p>In this paper, we measured B cell function in elderly healthy individuals (E<sub>H</sub>) and in elderly patients with Type-2 Diabetes Mellitus (T2DM, E<sub>T2DM</sub>), which are treatment-naive, as compared to healthy young (Y<sub>H</sub>) individuals. Results show a higher serum inflammatory status of elderly versus young individuals, and especially of E<sub>T2DM</sub> versus E<sub>H</sub>. This status is associated with a reduced response to the seasonal influenza vaccine and with increased frequencies of the circulating pro-inflammatory B cell subset called Double Negative (DN) B cells. B cells from E<sub>T2DM</sub> patients are not only more inflammatory but also hyper-metabolic as compared to those from E<sub>H</sub> controls. The results herein are to our knowledge the first to show that T2DM superimposed on aging further increases systemic and B cell intrinsic inflammation, as well as dysfunctional humoral immunity. Our findings confirm and extend our previously published findings showing that inflammatory B cells are metabolically supported.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-22eCollection Date: 2024-01-01DOI: 10.3389/fragi.2024.1483030
{"title":"Expression of concern: Simufilam suppresses overactive mTOR and restores its sensitivity to insulin in Alzheimer's disease patient lymphocytes.","authors":"","doi":"10.3389/fragi.2024.1483030","DOIUrl":"https://doi.org/10.3389/fragi.2024.1483030","url":null,"abstract":"","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-15eCollection Date: 2024-01-01DOI: 10.3389/fragi.2024.1376825
Sohvi Koponen, Irma Nykänen, Roosa-Maria Savela, Tarja Välimäki, Anna Liisa Suominen, Ursula Schwab
This study aimed to identify differences among body mass index (BMI) categories of older family caregivers (≥60 years) and their care recipients (≥65 years). Secondly, this study aimed to examine group differences and factors associated with weight change during a nutrition and oral health intervention. This secondary analysis of a randomized controlled trial (ClinicalTrial.gov (NCT04003493)) involved individually tailored nutritional guidance from a clinical nutritionist and oral health guidance from a dental hygienist. Baseline BMI differences were analyzed, followed by further analyses of group differences and associated factors of weight change over a 6-month period using generalized estimating equations. Among the participants (113 family caregivers and 107 care recipients), 36.3% and 35.1% were overweight (BMI >29 kg/m2), while 18.6% and 21.6% were underweight (BMI <24 kg/m2) at baseline, respectively. For family caregivers differences in BMI categories included age, mid-arm and calf circumferences, and plasma prealbumin concentration. For care recipients differences were observed in medication use, mid-arm and calf circumferences, Mini Nutritional Assessment scores, physical function, and number of teeth. During the 6-month intervention, there were no differences in weight change between intervention and control groups for both caregivers and care recipients. Factors significantly associated (p < 0.05) with weight loss included female sex for both caregivers and care recipients, and frailty for caregivers. Family caregivers' characteristics were not significantly associated with weight change in their care recipients. In conclusion, being overweight is a prevalent among older family caregivers and care recipients. Factors such as age, medication use, physical function, number of teeth, and Mini Nutritional Assessment scores varied across BMI categories. Female sex was associated with weight loss in both older family caregivers and care recipients, and frailty was associated with weight loss in caregivers. However, the characteristics of family caregivers did not explain the weight loss of their care recipients. Clinical Trial Registration: [https://www.ClinicalTrial.gov/], identifier [NCT04003493].
{"title":"Underweight, overweight, and weight change in older family caregivers and their care recipients: longitudinal evidence from a randomized controlled trial.","authors":"Sohvi Koponen, Irma Nykänen, Roosa-Maria Savela, Tarja Välimäki, Anna Liisa Suominen, Ursula Schwab","doi":"10.3389/fragi.2024.1376825","DOIUrl":"https://doi.org/10.3389/fragi.2024.1376825","url":null,"abstract":"<p><p>This study aimed to identify differences among body mass index (BMI) categories of older family caregivers (≥60 years) and their care recipients (≥65 years). Secondly, this study aimed to examine group differences and factors associated with weight change during a nutrition and oral health intervention. This secondary analysis of a randomized controlled trial (ClinicalTrial.gov (NCT04003493)) involved individually tailored nutritional guidance from a clinical nutritionist and oral health guidance from a dental hygienist. Baseline BMI differences were analyzed, followed by further analyses of group differences and associated factors of weight change over a 6-month period using generalized estimating equations. Among the participants (113 family caregivers and 107 care recipients), 36.3% and 35.1% were overweight (BMI >29 kg/m<sup>2</sup>), while 18.6% and 21.6% were underweight (BMI <24 kg/m<sup>2</sup>) at baseline, respectively. For family caregivers differences in BMI categories included age, mid-arm and calf circumferences, and plasma prealbumin concentration. For care recipients differences were observed in medication use, mid-arm and calf circumferences, Mini Nutritional Assessment scores, physical function, and number of teeth. During the 6-month intervention, there were no differences in weight change between intervention and control groups for both caregivers and care recipients. Factors significantly associated (<i>p</i> < 0.05) with weight loss included female sex for both caregivers and care recipients, and frailty for caregivers. Family caregivers' characteristics were not significantly associated with weight change in their care recipients. In conclusion, being overweight is a prevalent among older family caregivers and care recipients. Factors such as age, medication use, physical function, number of teeth, and Mini Nutritional Assessment scores varied across BMI categories. Female sex was associated with weight loss in both older family caregivers and care recipients, and frailty was associated with weight loss in caregivers. However, the characteristics of family caregivers did not explain the weight loss of their care recipients. Clinical Trial Registration: [https://www.ClinicalTrial.gov/], identifier [NCT04003493].</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11358125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-14eCollection Date: 2024-01-01DOI: 10.3389/fragi.2024.1380838
Lise Amy Hansen, Wendy Keay-Bright, Felicia Nilsson, Heidi Wilson
This article describes an approach to developing and maintaining interpersonal agency through guided movement and responsive technologies. Making Movement Irresistible (MMI), considered conditions for developing a digital, online and wearable intervention that could make the act of movement irresistible for older residents in care, and encourage improvisational and social interactions. Working within a co-design framework, we combined making material objects and moving together as a method of examining the efficacy of human to human, and human to technology relationships to cultivate agency. Given that movement as performance is frequently not practiced or uncomfortable, we invited a variety of experts as our co-designers to notice the nuances of movement that interested them and to document these using drawing, writing and visuals. This documentation was gathered regularly in journals as the workshops progressed, leading to a coherent capture of data as it emerged. This data allowed us to attribute value to how simple actions could become a conduit for more ambitious, exploratory interactions. Our playful methods afforded the participation of co-designers, enabling us to situate our proposed intervention within a relational and social, rather than medical model, of ageing. Making movement do-able and relational, so that it can be shared and extended with a partner or carer, informed the idea to design a wearable device that could detect movement variability, resulting in a prototype, named emitts®. The device makes use of the hand as way in to accessing whole body interaction. Our work with responsiveness of visual feedback avoided deterministic targets, as with no two movements being identical, the reported problem of compliance with repetitive tasks could be reduced. The technology foregrounded movement that was capricious and improvisational, offering new modes of artistic practice and engagement through play and performance. The case we describe highlights the importance of understanding the conditions that augment social interaction, rather than specifying design criteria for determining interaction. The longer-term health benefits of our intervention have yet to be measured, however, our collaboration has revealed how interpersonal agency emerges when we socially, aesthetically, and physiologically stimulate movement, making it irresistible where there may otherwise be resistance.
{"title":"Anticipation, agency and aging-conditions for making movement irresistible.","authors":"Lise Amy Hansen, Wendy Keay-Bright, Felicia Nilsson, Heidi Wilson","doi":"10.3389/fragi.2024.1380838","DOIUrl":"https://doi.org/10.3389/fragi.2024.1380838","url":null,"abstract":"<p><p>This article describes an approach to developing and maintaining interpersonal agency through guided movement and responsive technologies. Making Movement Irresistible (MMI), considered conditions for developing a digital, online and wearable intervention that could make the act of movement irresistible for older residents in care, and encourage improvisational and social interactions. Working within a co-design framework, we combined making material objects and moving together as a method of examining the efficacy of human to human, and human to technology relationships to cultivate agency. Given that movement as performance is frequently not practiced or uncomfortable, we invited a variety of experts as our co-designers to notice the nuances of movement that interested them and to document these using drawing, writing and visuals. This documentation was gathered regularly in journals as the workshops progressed, leading to a coherent capture of data as it emerged. This data allowed us to attribute value to how simple actions could become a conduit for more ambitious, exploratory interactions. Our playful methods afforded the participation of co-designers, enabling us to situate our proposed intervention within a relational and social, rather than medical model, of ageing. Making movement do-able and relational, so that it can be shared and extended with a partner or carer, informed the idea to design a wearable device that could detect movement variability, resulting in a prototype, named emitts<sup>®.</sup> The device makes use of the hand as way in to accessing whole body interaction. Our work with responsiveness of visual feedback avoided deterministic targets, as with no two movements being identical, the reported problem of compliance with repetitive tasks could be reduced. The technology foregrounded movement that was capricious and improvisational, offering new modes of artistic practice and engagement through play and performance. The case we describe highlights the importance of understanding the conditions that augment social interaction, rather than specifying design criteria for determining interaction. The longer-term health benefits of our intervention have yet to be measured, however, our collaboration has revealed how interpersonal agency emerges when we socially, aesthetically, and physiologically stimulate movement, making it irresistible where there may otherwise be resistance.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11349693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-13eCollection Date: 2024-01-01DOI: 10.3389/fragi.2024.1416447
Tina Woods, Nic Palmarini, Lynne Corner, Richard Siow
{"title":"Quantum healthy longevity from cells to cities.","authors":"Tina Woods, Nic Palmarini, Lynne Corner, Richard Siow","doi":"10.3389/fragi.2024.1416447","DOIUrl":"10.3389/fragi.2024.1416447","url":null,"abstract":"","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11347422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-05eCollection Date: 2024-01-01DOI: 10.3389/fragi.2024.1471233
Aurélie Ledreux, Consuelo Borrás
{"title":"Editorial: Women in molecular mechanisms of aging.","authors":"Aurélie Ledreux, Consuelo Borrás","doi":"10.3389/fragi.2024.1471233","DOIUrl":"https://doi.org/10.3389/fragi.2024.1471233","url":null,"abstract":"","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11330867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142006081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-29eCollection Date: 2024-01-01DOI: 10.3389/fragi.2024.1353272
Maximilian Unfried
In an era marked by scientific stagnation, Decentralized Science (DeSci) challenges the inefficiencies of traditional funding and publishing systems. DeSci employs blockchain technology to address the misalignment of incentives in academic research, emphasizing transparency, rapid funding, and open-source principles. Centralized institutions have been linked to a deceleration of progress, which is acutely felt in the field of longevity science-a critical discipline as aging is the #1 risk factor for most diseases. DeSci proposes a transformative model where decentralized autonomous organizations (DAOs) facilitate community-driven funding, promoting high-risk, high-reward research. DeSci, particularly within longevity research, could catalyze a paradigm shift towards an equitable, efficient, and progressive scientific future.
{"title":"Advancing longevity research through decentralized science.","authors":"Maximilian Unfried","doi":"10.3389/fragi.2024.1353272","DOIUrl":"10.3389/fragi.2024.1353272","url":null,"abstract":"<p><p>In an era marked by scientific stagnation, Decentralized Science (DeSci) challenges the inefficiencies of traditional funding and publishing systems. DeSci employs blockchain technology to address the misalignment of incentives in academic research, emphasizing transparency, rapid funding, and open-source principles. Centralized institutions have been linked to a deceleration of progress, which is acutely felt in the field of longevity science-a critical discipline as aging is the #1 risk factor for most diseases. DeSci proposes a transformative model where decentralized autonomous organizations (DAOs) facilitate community-driven funding, promoting high-risk, high-reward research. DeSci, particularly within longevity research, could catalyze a paradigm shift towards an equitable, efficient, and progressive scientific future.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11317406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-29eCollection Date: 2024-01-01DOI: 10.3389/fragi.2024.1429156
Lev Salnikov
The article gives a brief description of geroprotection and rejuvenation methods known to date, presenting their main mechanisms and limitations. To overcome the main limitations of the process of rejuvenation, it is possible to use a process called "cell autocloning." The principle of the proposed method of rejuvenation is as follows: a periodic process of autocloning of the cell nucleus is initiated in the cellular genome with the formation of one unstable daughter copy and its subsequent self-elimination. In this case, the process of cell division stops in the phase of nuclei divergence without subsequent physical separation of the cell itself. This is especially important for postmitotic cells, where the looping of the "unidirectional" line of the ontogenesis program into a "ring" will mean their transition into renewable cells. The prototype for autocloning mechanisms could be the already known ways in which cells adapt to the increasing amount of their damage over time. These are polyploidy and asymmetric cell division, relying on which it is possible to obtain a renewable process of cell nuclei division, when only the original nucleus remains as a result of division. Although this is not a simple task, there are possible pathways to its solution using approaches that can suggest modern knowledge from the field of molecular and cell biology and genetics. The realization of such a goal will require a lot of work, but the expected result justifies it.
{"title":"Cell autocloning as a pathway to their real rejuvenation.","authors":"Lev Salnikov","doi":"10.3389/fragi.2024.1429156","DOIUrl":"10.3389/fragi.2024.1429156","url":null,"abstract":"<p><p>The article gives a brief description of geroprotection and rejuvenation methods known to date, presenting their main mechanisms and limitations. To overcome the main limitations of the process of rejuvenation, it is possible to use a process called \"cell autocloning.\" The principle of the proposed method of rejuvenation is as follows: a periodic process of autocloning of the cell nucleus is initiated in the cellular genome with the formation of one unstable daughter copy and its subsequent self-elimination. In this case, the process of cell division stops in the phase of nuclei divergence without subsequent physical separation of the cell itself. This is especially important for postmitotic cells, where the looping of the \"unidirectional\" line of the ontogenesis program into a \"ring\" will mean their transition into renewable cells. The prototype for autocloning mechanisms could be the already known ways in which cells adapt to the increasing amount of their damage over time. These are polyploidy and asymmetric cell division, relying on which it is possible to obtain a renewable process of cell nuclei division, when only the original nucleus remains as a result of division. Although this is not a simple task, there are possible pathways to its solution using approaches that can suggest modern knowledge from the field of molecular and cell biology and genetics. The realization of such a goal will require a lot of work, but the expected result justifies it.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11317467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-11eCollection Date: 2024-01-01DOI: 10.3389/fragi.2024.1408160
Samantha McLean, Mitchell Lee, Weiqiang Liu, Rohil Hameed, Vikas Anil Gujjala, Xuming Zhou, Matt Kaeberlein, Alaattin Kaya
Caloric restriction (CR) is known to extend lifespan across different species and holds great promise for preventing human age-onset pathologies. However, two major challenges exist. First, despite extensive research, the mechanisms of lifespan extension in response to CR remain elusive. Second, genetic differences causing variations in response to CR and genetic factors contributing to variability of CR response on lifespan are largely unknown. Here, we took advantage of natural genetic variation across 46 diploid wild yeast isolates of Saccharomyces species and the lifespan variation under CR conditions to uncover the molecular factors associated with CR response types. We identified genes and metabolic pathways differentially regulated in CR-responsive versus non-responsive strains. Our analysis revealed that altered mitochondrial function and activation of GCN4-mediated environmental stress response are inevitably linked to lifespan variation in response to CR and a unique mitochondrial metabolite might be utilized as a predictive marker for CR response rate. In sum, our data suggests that the effects of CR on longevity may not be universal, even among the closely related species or strains of a single species. Since mitochondrial-mediated signaling pathways are evolutionarily conserved, the dissection of related genetic pathways will be relevant to understanding the mechanism by which CR elicits its longevity effect.
{"title":"Molecular mechanisms of genotype-dependent lifespan variation mediated by caloric restriction: insight from wild yeast isolates.","authors":"Samantha McLean, Mitchell Lee, Weiqiang Liu, Rohil Hameed, Vikas Anil Gujjala, Xuming Zhou, Matt Kaeberlein, Alaattin Kaya","doi":"10.3389/fragi.2024.1408160","DOIUrl":"10.3389/fragi.2024.1408160","url":null,"abstract":"<p><p>Caloric restriction (CR) is known to extend lifespan across different species and holds great promise for preventing human age-onset pathologies. However, two major challenges exist. First, despite extensive research, the mechanisms of lifespan extension in response to CR remain elusive. Second, genetic differences causing variations in response to CR and genetic factors contributing to variability of CR response on lifespan are largely unknown. Here, we took advantage of natural genetic variation across 46 diploid wild yeast isolates of <i>Saccharomyces</i> species and the lifespan variation under CR conditions to uncover the molecular factors associated with CR response types. We identified genes and metabolic pathways differentially regulated in CR-responsive <i>versus</i> non-responsive strains. Our analysis revealed that altered mitochondrial function and activation of <i>GCN4-</i>mediated environmental stress response are inevitably linked to lifespan variation in response to CR and a unique mitochondrial metabolite might be utilized as a predictive marker for CR response rate. In sum, our data suggests that the effects of CR on longevity may not be universal, even among the closely related species or strains of a single species. Since mitochondrial-mediated signaling pathways are evolutionarily conserved, the dissection of related genetic pathways will be relevant to understanding the mechanism by which CR elicits its longevity effect.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11269085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141763062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01eCollection Date: 2024-01-01DOI: 10.3389/fragi.2024.1432858
Changhan Lee, Jianhua Zhang
{"title":"Editorial: Insights in aging, metabolism and redox biology.","authors":"Changhan Lee, Jianhua Zhang","doi":"10.3389/fragi.2024.1432858","DOIUrl":"https://doi.org/10.3389/fragi.2024.1432858","url":null,"abstract":"","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11246841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}