Proteomic alterations in patients with atopic dermatitis.

IF 4.7 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-05-16 DOI:10.1080/14789450.2024.2350938

Ashley Obi, Camille Rothenberg-Lausell, Sophia Levit, Ester Del Duca, E. Guttman‐Yassky

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Abstract

INTRODUCTION AtopicDermatitis (AD) is the most common inflammatory skin disease with a complex andmultifactorial pathogenesis. The use of proteomics in understanding AD hasyielded the discovery of novel biomarkers and may further expand therapeuticoptions. AREASCOVERED Thisreview summarizes the most recent proteomic studies and the methodologies usedin AD. It describes novel biomarkers that may monitor disease course andtherapeutic response. The review also highlights skin and blood biomarkerscharacterizing different AD phenotypes and differentiates AD from otherinflammatory skin disorders. A literature search was conducted by queryingScopus, Google Scholar, Pubmed/Medline, and Clinicaltrials.gov up to June 2023. EXPERTOPINION Theintegration of proteomics into research efforts in atopic dermatitis hasbroadened our understanding of the molecular profile of AD through thediscovery of new biomarkers. In addition, proteomics may contribute to thedevelopment of targeted treatments ultimately improving personalized medicine.An increasing number of studies are utilizing proteomics to explore thisheterogeneous disease.

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特应性皮炎患者的蛋白质组变化。

简介特异性皮炎（AD）是最常见的炎症性皮肤病，其发病机制复杂且多因素。本综述总结了最新的蛋白质组学研究以及在 AD 中使用的方法。它描述了可监测疾病进程和治疗反应的新型生物标志物。综述还强调了表征不同 AD 表型的皮肤和血液生物标记物，并将 AD 与其他炎症性皮肤病区分开来。通过查询Scopus、Google Scholar、Pubmed/Medline和Clinicaltrials.gov（截至2023年6月）进行了文献检索。专家观点将蛋白质组学纳入特应性皮炎的研究工作，通过发现新的生物标记物，拓宽了我们对AD分子特征的了解。此外，蛋白质组学还有助于开发有针对性的治疗方法，最终改善个性化医疗。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567

期刊介绍： ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/Abstracted： Web of Science SCIE Scopus CAS INSPEC Portico

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