Depressive symptoms are not associated with predementia CSF amyloid pathology

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-05-10 DOI:10.1159/000539284

C. Eriksson, Bjørn-Eivind Kirsebom, Ragna Espenes, N. Siafarikas, K. Waterloo, A. Rongve, P. Selnes, Dag Aarsland, T. Fladby, Erik Hessen

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Abstract

ABSTRACT INTRODUCTION: Depressive symptoms are associated with Alzheimer’s disease (AD), but their neurobiological and neuropsychological correlates remain poorly understood. We investigate if depressive symptoms are associated with amyloid (Aβ) pathology and cognition in predementia AD. METHODS: We included Subjective Cognitive Decline (SCD, n= 160) and Mild Cognitive Impairment (MCI, n=192) from the Dementia Disease Initiation cohort. Depressive symptoms were assessed using the Geriatric Depression Scale (GDS-15). Aβ pathology was determined using cerebrospinal fluid (CSF) Aβ42/40 ratio. Associations between depressive symptoms and cognition were assessed with logistic regression. RESULTS: Only the Aβ negative MCI group (MCI-Aβ-) was associated with depressive symptoms (OR=2.65, p=.005). Depressive symptoms were associated with worse memory in MCI-Aβ- (OR=0.94, p=.039), but with better performance in MCI-Aβ+ (OR=1.103, p=.001). DISCUSSION: Our results suggest that depressive symptoms in MCI are neither associated with Aβ pathology, nor AD-associated memory impairment. However, memory impairment in non-AD MCI may relate to depressive symptoms.

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抑郁症状与痴呆前脑脊液淀粉样病理无关

摘要：抑郁症状与阿尔茨海默病（AD）有关，但其神经生物学和神经心理学相关性仍鲜为人知。我们研究了抑郁症状是否与痴呆前期阿尔茨海默病的淀粉样蛋白（Aβ）病理和认知相关。方法：我们纳入了痴呆症起始队列中的主观认知功能减退（SCD，人数=160）和轻度认知功能障碍（MCI，人数=192）患者。抑郁症状采用老年抑郁量表（GDS-15）进行评估。通过脑脊液（CSF）Aβ42/40比值确定Aβ病理学。抑郁症状与认知能力之间的关系通过逻辑回归进行评估。结果：只有 Aβ 阴性 MCI 组（MCI-Aβ-）与抑郁症状相关（OR=2.65，p=.005）。抑郁症状与 MCI-Aβ- 组记忆力较差有关（OR=0.94，p=.039），但与 MCI-Aβ+ 组记忆力较好有关（OR=1.103，p=.001）。讨论：我们的研究结果表明，MCI患者的抑郁症状既与Aβ病理学无关，也与AD相关的记忆损伤无关。然而，非 AD MCI 患者的记忆损伤可能与抑郁症状有关。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.