首页 > 最新文献

Dementia and Geriatric Cognitive Disorders Extra最新文献

英文 中文
Fear of Dementia among Middle-Aged and Older Adults in Germany. 德国中老年人对痴呆症的恐惧。
IF 1.4 Q4 CLINICAL NEUROLOGY Pub Date : 2024-09-12 eCollection Date: 2024-01-01 DOI: 10.1159/000541066
Jan-Luca Meyer, Elzbieta Buczak-Stec, Hans-Helmut König, André Hajek

Introduction: The objective of this study was to clarify the frequency of fear of dementia and the factors associated with it.

Methods: Data were taken from a nationally representative sample (n = 4,000; average age was 54.9 years, SD: 8.5 years, age ranges from 40 to 70 years, 49.6% of the respondents were women). Similar to prior research, fear of dementia was quantified using a tool ranging from 1 (no fear of dementia) to 4 (severe fear of dementia).

Results: In sum, 19.0% reported no fear of dementia, 34.6% reported a little fear of dementia, 33.8% reported some fear of dementia, and 12.7% reported severe fear of dementia. Regressions showed that greater fear of dementia was significantly associated with being female, being younger, poorer self-rated health, the presence of at least one chronic disease, not living in the same household with a partner or not being in a relationship at all, having depressive symptoms and anxiety symptoms.

Conclusion: Study findings showed that fear of dementia is particularly associated with health-related factors, age and gender. Lifestyle factors and other socioeconomic factors were only occasionally significant. Future research should explore the reasons for such a higher frequency of people's fear of dementia. It would also be interesting to find out new factors associated with the fear of dementia. Furthermore, further research could focus on cross-country comparisons and could stratify the results by important groups, e.g., by sex or education, but also cultural and ethnic aspects.

导言本研究旨在明确人们对痴呆症的恐惧频率及其相关因素:数据来自一个具有全国代表性的样本(n = 4000;平均年龄为 54.9 岁,SD:8.5 岁,年龄在 40 岁至 70 岁之间,49.6% 的受访者为女性)。与之前的研究类似,对痴呆症的恐惧程度也采用了从 1(不恐惧痴呆症)到 4(严重恐惧痴呆症)的量化工具:总之,19.0% 的人表示不害怕痴呆症,34.6% 的人表示有点害怕痴呆症,33.8% 的人表示有点害怕痴呆症,12.7% 的人表示严重害怕痴呆症。回归结果显示,对痴呆症的恐惧与女性、年龄较小、自评健康状况较差、至少患有一种慢性疾病、未与伴侣生活在同一家庭或根本没有伴侣关系、有抑郁症状和焦虑症状有明显关联:研究结果表明,对痴呆症的恐惧尤其与健康相关因素、年龄和性别有关。生活方式因素和其他社会经济因素只是偶尔有意义。未来的研究应探讨人们对痴呆症的恐惧频率如此之高的原因。此外,找出与痴呆症恐惧相关的新因素也很有意义。此外,进一步的研究可以侧重于跨国比较,并按重要群体(如性别或教育程度,以及文化和种族方面)对结果进行分层。
{"title":"Fear of Dementia among Middle-Aged and Older Adults in Germany.","authors":"Jan-Luca Meyer, Elzbieta Buczak-Stec, Hans-Helmut König, André Hajek","doi":"10.1159/000541066","DOIUrl":"https://doi.org/10.1159/000541066","url":null,"abstract":"<p><strong>Introduction: </strong>The objective of this study was to clarify the frequency of fear of dementia and the factors associated with it.</p><p><strong>Methods: </strong>Data were taken from a nationally representative sample (<i>n</i> = 4,000; average age was 54.9 years, SD: 8.5 years, age ranges from 40 to 70 years, 49.6% of the respondents were women). Similar to prior research, fear of dementia was quantified using a tool ranging from 1 (no fear of dementia) to 4 (severe fear of dementia).</p><p><strong>Results: </strong>In sum, 19.0% reported no fear of dementia, 34.6% reported a little fear of dementia, 33.8% reported some fear of dementia, and 12.7% reported severe fear of dementia. Regressions showed that greater fear of dementia was significantly associated with being female, being younger, poorer self-rated health, the presence of at least one chronic disease, not living in the same household with a partner or not being in a relationship at all, having depressive symptoms and anxiety symptoms.</p><p><strong>Conclusion: </strong>Study findings showed that fear of dementia is particularly associated with health-related factors, age and gender. Lifestyle factors and other socioeconomic factors were only occasionally significant. Future research should explore the reasons for such a higher frequency of people's fear of dementia. It would also be interesting to find out new factors associated with the fear of dementia. Furthermore, further research could focus on cross-country comparisons and could stratify the results by important groups, e.g., by sex or education, but also cultural and ethnic aspects.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of Alzheimer's Disease and Mild Cognitive Impairment Influenced by the Time of Onset. 阿尔茨海默病和轻度认知障碍的特征受发病时间的影响。
IF 1.4 Q4 CLINICAL NEUROLOGY Pub Date : 2024-09-09 eCollection Date: 2024-01-01 DOI: 10.1159/000541092
Hiroyuki Sato, Miho Ota, Ayako Kitabatake, Yuriko Numata, Takumi Takahashi, Masashi Tamura, Kiyotaka Nemoto, Tetsuaki Arai

Introduction: Although the prevalence of Alzheimer's disease (AD) is higher in older people compared to younger people, dementia has also been documented in younger adults. Although early-onset dementia and late-onset dementia had been considered a single disease in pathological investigations, many studies revealed differences in cognitive and neuroimaging changes between them. We evaluated differences in cognitive and neuroimaging changes among the following groups: individuals with early-onset AD (EOAD), late-onset AD (LOAD), early-onset mild cognitive impairment (EOMCI), or late-onset MCI (LOMCI), and healthy controls (HCs).

Methods: Patients underwent both a 1.5 Tesla magnetic resonance imaging scan and the Mini-Mental State Examination (MMSE). Differences in regional gray matter volumes and MMSE subscales were investigated among the five diagnostic groups.

Results: Compared to the EOAD group, the LOAD group had significantly higher scores on orientation in place. Compared to the LOMCI patients, the EOMCI patients achieved significantly higher recall scores. The LOAD and LOMC groups showed significant volume reductions in bilateral medial temporal regions compared to the HCs. The EOAD and EOMCI groups did not show significant atrophy of the medial temporal region compared to the HC group.

Conclusions: The hippocampal volume and memory were preserved in the patients with EOMCI or EOAD compared to those with LOMCI or LOAD. These findings may indicate that the distinct and differing patterns of neuropsychological changes between EOAD and LOAD are also common in MCI, which is intermediate between normal cognition and AD.

简介虽然阿尔茨海默病(AD)在老年人中的发病率高于年轻人,但在年轻人中也有痴呆症的记录。虽然在病理研究中,早发性痴呆症和晚发性痴呆症被认为是同一种疾病,但许多研究揭示了这两种疾病在认知和神经影像学变化上的差异。我们评估了以下群体在认知和神经影像学变化方面的差异:早发 AD(EOAD)、晚发 AD(LOAD)、早发轻度认知障碍(EOMCI)或晚发 MCI(LOMCI)患者,以及健康对照组(HCs):患者同时接受 1.5 特斯拉磁共振成像扫描和迷你精神状态检查(MMSE)。结果:与 EOAD 组相比,MMSE 组患者的灰质体积更小,而 EOAD 组患者的灰质体积更大:结果:与EOAD组相比,LOAD组在原地定向方面的得分明显更高。与 LOMCI 患者相比,EOMCI 患者的回忆得分明显更高。与HCs相比,LOAD组和LOMC组的双侧颞内侧区域体积明显缩小。与HC组相比,EOAD组和EOMCI组的内侧颞区并未出现明显萎缩:结论:与LOMCI或LOAD患者相比,EOMCI或EOAD患者的海马体积和记忆力均有所保留。这些发现可能表明,EOAD和LOAD之间不同的神经心理学变化模式在介于正常认知和AD之间的MCI中也很常见。
{"title":"Characteristics of Alzheimer's Disease and Mild Cognitive Impairment Influenced by the Time of Onset.","authors":"Hiroyuki Sato, Miho Ota, Ayako Kitabatake, Yuriko Numata, Takumi Takahashi, Masashi Tamura, Kiyotaka Nemoto, Tetsuaki Arai","doi":"10.1159/000541092","DOIUrl":"https://doi.org/10.1159/000541092","url":null,"abstract":"<p><strong>Introduction: </strong>Although the prevalence of Alzheimer's disease (AD) is higher in older people compared to younger people, dementia has also been documented in younger adults. Although early-onset dementia and late-onset dementia had been considered a single disease in pathological investigations, many studies revealed differences in cognitive and neuroimaging changes between them. We evaluated differences in cognitive and neuroimaging changes among the following groups: individuals with early-onset AD (EOAD), late-onset AD (LOAD), early-onset mild cognitive impairment (EOMCI), or late-onset MCI (LOMCI), and healthy controls (HCs).</p><p><strong>Methods: </strong>Patients underwent both a 1.5 Tesla magnetic resonance imaging scan and the Mini-Mental State Examination (MMSE). Differences in regional gray matter volumes and MMSE subscales were investigated among the five diagnostic groups.</p><p><strong>Results: </strong>Compared to the EOAD group, the LOAD group had significantly higher scores on orientation in place. Compared to the LOMCI patients, the EOMCI patients achieved significantly higher recall scores. The LOAD and LOMC groups showed significant volume reductions in bilateral medial temporal regions compared to the HCs. The EOAD and EOMCI groups did not show significant atrophy of the medial temporal region compared to the HC group.</p><p><strong>Conclusions: </strong>The hippocampal volume and memory were preserved in the patients with EOMCI or EOAD compared to those with LOMCI or LOAD. These findings may indicate that the distinct and differing patterns of neuropsychological changes between EOAD and LOAD are also common in MCI, which is intermediate between normal cognition and AD.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Geriatric Syndromes among Older Outpatients with Dementia. 老年痴呆症老年门诊病人的老年综合症患病率。
IF 1.4 Q4 CLINICAL NEUROLOGY Pub Date : 2024-09-02 eCollection Date: 2024-01-01 DOI: 10.1159/000541237
Luc Viet Tran, Thanh Xuan Nguyen, Thu Thi Hoai Nguyen, Huong Thi Thu Nguyen, Tam Ngoc Nguyen, Anh Lan Nguyen, Vasikaran Naganathan, Janani Thillainadesan, Huong Thi Thanh Nguyen, Anh Trung Nguyen, Huyen Thi Thanh Vu

Introduction: The identification of geriatric syndromes in people with dementia is important. The aim of the study was to assess the prevalence of geriatric syndromes among dementia outpatients.

Methods: A cross-sectional study was conducted enrolling outpatients with dementia aged ≥60 years old. Dementia was diagnosed by neuropsychiatrists following DSM-5 criteria. The geriatric syndromes assessed included nutritional status (Mini Nutritional Assessment Scale-Short Form), polypharmacy, comorbidities, alcohol use, depression (quality of life in Alzheimer disease), functional status (Barthel Index, Instrumental Activities of Daily Living); lower body strength (30 s stand chair test), and frailty (Timed Up and Go test ≥14 s).

Results: A total of 87 participants was recruited in the study (mean age: 76.8 ± 1.2 years; female: 65.5%). The median number of geriatric syndromes per participant was 5 (IQR = 2); all participants had two or more geriatric syndromes. The most common geriatric syndromes were loss of independence (96.6% impairment in >1 IADL task score and 74.7% dependency in physical function at based on Barthel Index), reduced lower body strength (86.2%), malnutrition and risk of malnutrition (78.2%), and frailty (67.8%). Current and history of smoking, drinking alcohol, using memantine therapy, malnourishment and risk of malnourishment were significantly associated with increasing severity of dementia.

Conclusion: The presence and coincidence of geriatric syndromes is common among outpatients with dementia. These findings have important clinical implications in terms of the assessment and service delivery for older adults in Vietnam. We are exploring ways to enhance our services to provide comprehensive, multidisciplinary approaches to screening, recognition, and treatment of geriatric syndromes in older adults with dementia.

引言识别痴呆症患者的老年综合征非常重要。本研究旨在评估老年痴呆症门诊患者中老年综合征的发病率:方法:对年龄≥60 岁的痴呆症门诊患者进行横断面研究。痴呆症由神经精神科医生根据 DSM-5 标准诊断。评估的老年综合征包括营养状况(迷你营养评估量表-简表)、多药治疗、合并症、饮酒、抑郁(阿尔茨海默病的生活质量)、功能状况(巴特尔指数、日常生活器械活动)、下肢力量(30 秒站立坐椅测试)和虚弱程度(≥14 秒定时起立行走测试):研究共招募了 87 名参与者(平均年龄:76.8 ± 1.2 岁;女性:65.5%)。每位参与者的老年综合征中位数为 5 种(IQR = 2);所有参与者都有两种或两种以上的老年综合征。最常见的老年病综合征是丧失独立能力(根据巴特尔指数,96.6%的人在>1 项 IADL 任务中受损,74.7%的人在身体功能上依赖)、下半身力量减弱(86.2%)、营养不良和营养不良风险(78.2%)以及虚弱(67.8%)。吸烟、饮酒、使用美金刚治疗、营养不良和营养不良风险与痴呆症的严重程度显著相关:结论:老年痴呆症门诊患者中,老年综合征的存在和并发很常见。这些发现对越南老年人的评估和服务提供具有重要的临床意义。我们正在探索如何加强我们的服务,为老年痴呆症患者提供全面、多学科的老年综合征筛查、识别和治疗方法。
{"title":"Prevalence of Geriatric Syndromes among Older Outpatients with Dementia.","authors":"Luc Viet Tran, Thanh Xuan Nguyen, Thu Thi Hoai Nguyen, Huong Thi Thu Nguyen, Tam Ngoc Nguyen, Anh Lan Nguyen, Vasikaran Naganathan, Janani Thillainadesan, Huong Thi Thanh Nguyen, Anh Trung Nguyen, Huyen Thi Thanh Vu","doi":"10.1159/000541237","DOIUrl":"https://doi.org/10.1159/000541237","url":null,"abstract":"<p><strong>Introduction: </strong>The identification of geriatric syndromes in people with dementia is important. The aim of the study was to assess the prevalence of geriatric syndromes among dementia outpatients.</p><p><strong>Methods: </strong>A cross-sectional study was conducted enrolling outpatients with dementia aged ≥60 years old. Dementia was diagnosed by neuropsychiatrists following DSM-5 criteria. The geriatric syndromes assessed included nutritional status (Mini Nutritional Assessment Scale-Short Form), polypharmacy, comorbidities, alcohol use, depression (quality of life in Alzheimer disease), functional status (Barthel Index, Instrumental Activities of Daily Living); lower body strength (30 s stand chair test), and frailty (Timed Up and Go test ≥14 s).</p><p><strong>Results: </strong>A total of 87 participants was recruited in the study (mean age: 76.8 ± 1.2 years; female: 65.5%). The median number of geriatric syndromes per participant was 5 (IQR = 2); all participants had two or more geriatric syndromes. The most common geriatric syndromes were loss of independence (96.6% impairment in >1 IADL task score and 74.7% dependency in physical function at based on Barthel Index), reduced lower body strength (86.2%), malnutrition and risk of malnutrition (78.2%), and frailty (67.8%). Current and history of smoking, drinking alcohol, using memantine therapy, malnourishment and risk of malnourishment were significantly associated with increasing severity of dementia.</p><p><strong>Conclusion: </strong>The presence and coincidence of geriatric syndromes is common among outpatients with dementia. These findings have important clinical implications in terms of the assessment and service delivery for older adults in Vietnam. We are exploring ways to enhance our services to provide comprehensive, multidisciplinary approaches to screening, recognition, and treatment of geriatric syndromes in older adults with dementia.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Criterion-Related Validity of the Cognitive Function Score with the Revised Hasegawa's Dementia Scale and the Bedriddenness Rank with the Barthel Index and the Katz Index: A Multi-Center Retrospective Study. 认知功能评分与修订版长谷川痴呆量表以及卧床不起等级与巴特尔指数和卡茨指数的标准相关有效性:一项多中心回顾性研究。
IF 1.4 Q4 CLINICAL NEUROLOGY Pub Date : 2024-07-30 eCollection Date: 2024-01-01 DOI: 10.1159/000540430
Risa Hirata, Naoko E Katsuki, Hitomi Shimada, Eiji Nakatani, Kiyoshi Shikino, Maiko Ono, Chihiro Saito, Kaori Amari, Kazuya Kurogi, Mariko Yoshimura, Tomoyo Nishi, Shizuka Yaita, Yoshimasa Oda, Midori Tokushima, Yuka Hirakawa, Masahiko Nakamura, Shun Yamashita, Yoshinori Tokushima, Hidetoshi Aihara, Motoshi Fujiwara, Masaki Tago

Introduction: The cognitive function score (CFS) is a public scale for assessing the activities of daily living (ADL) in older adults with dementia in Japan. In contrast, the scores of the revised Hasegawa's dementia scale (HDS-R), an easy-to-use dementia screening tool developed in Japan, are significantly correlated with mini-mental state examination scores and are widely utilized in various countries. This novel study aimed to elucidate the previously unexplored criterion-related validity of the CFS and HDS-R and the Bedriddenness Rank (BR), Barthel index (BI), and Katz index (KI).

Methods: This was a multicenter retrospective study and a secondary analysis of our previous study. The study included patients aged ≥20 years hospitalized in chronic care settings between April 1, 2018, and March 31, 2021. We collected data from medical charts on admission, including age, sex, the BR, CFS, BI, KI, and HDS-R scores. Correlations between the CFS and HDS-R score, as well as between the BR and BI or KI, were analyzed using Spearman's rank correlation coefficients.

Results: A total of 749 participants were included in the analysis of criterion-related validity between the CFS and HDS-R. In the CFS cohort analysis, 202 patients (27.0%) were categorized as having a normal CFS, and the median HDS-R score was 18 (range: 6-26). The correlation coefficient between the CFS and HDS-R scores was -0.834 (p < 0.001). The correlation coefficient between BR and BI was -0.741 (p < 0.001), BR and KI was -0.740 (p < 0.001).

Conclusion: The CFS revealed significant criterion-related validity compared with the established cognitive assessment scale, the HDS-R. The BR also demonstrated significant criterion-related validity with the BI and KI.

简介认知功能评分(CFS)是日本用于评估老年痴呆症患者日常生活活动能力(ADL)的公共量表。相比之下,修订版长谷川痴呆量表(HDS-R)是日本开发的一种易于使用的痴呆筛查工具,其得分与迷你精神状态检查得分显著相关,并在各国广泛使用。这项新研究旨在阐明 CFS 和 HDS-R 与 Bedriddenness Rank (BR)、Barthel index (BI) 和 Katz index (KI) 标准相关的有效性:这是一项多中心回顾性研究,也是对我们之前研究的二次分析。研究对象包括2018年4月1日至2021年3月31日期间在慢性病护理机构住院的年龄≥20岁的患者。我们从入院时的病历中收集了数据,包括年龄、性别、BR、CFS、BI、KI 和 HDS-R 评分。我们使用斯皮尔曼等级相关系数分析了CFS和HDS-R评分之间以及BR和BI或KI之间的相关性:共有 749 名参与者参与了 CFS 和 HDS-R 标准相关有效性分析。在CFS队列分析中,有202名患者(27.0%)被归类为正常CFS,HDS-R评分的中位数为18分(范围:6-26)。CFS和HDS-R评分之间的相关系数为-0.834(p < 0.001)。BR与BI的相关系数为-0.741(P < 0.001),BR与KI的相关系数为-0.740(P < 0.001):与已有的认知评估量表(HDS-R)相比,CFS具有明显的标准相关有效性。与 BI 和 KI 相比,BR 也显示出明显的标准相关有效性。
{"title":"Criterion-Related Validity of the Cognitive Function Score with the Revised Hasegawa's Dementia Scale and the Bedriddenness Rank with the Barthel Index and the Katz Index: A Multi-Center Retrospective Study.","authors":"Risa Hirata, Naoko E Katsuki, Hitomi Shimada, Eiji Nakatani, Kiyoshi Shikino, Maiko Ono, Chihiro Saito, Kaori Amari, Kazuya Kurogi, Mariko Yoshimura, Tomoyo Nishi, Shizuka Yaita, Yoshimasa Oda, Midori Tokushima, Yuka Hirakawa, Masahiko Nakamura, Shun Yamashita, Yoshinori Tokushima, Hidetoshi Aihara, Motoshi Fujiwara, Masaki Tago","doi":"10.1159/000540430","DOIUrl":"https://doi.org/10.1159/000540430","url":null,"abstract":"<p><strong>Introduction: </strong>The cognitive function score (CFS) is a public scale for assessing the activities of daily living (ADL) in older adults with dementia in Japan. In contrast, the scores of the revised Hasegawa's dementia scale (HDS-R), an easy-to-use dementia screening tool developed in Japan, are significantly correlated with mini-mental state examination scores and are widely utilized in various countries. This novel study aimed to elucidate the previously unexplored criterion-related validity of the CFS and HDS-R and the Bedriddenness Rank (BR), Barthel index (BI), and Katz index (KI).</p><p><strong>Methods: </strong>This was a multicenter retrospective study and a secondary analysis of our previous study. The study included patients aged ≥20 years hospitalized in chronic care settings between April 1, 2018, and March 31, 2021. We collected data from medical charts on admission, including age, sex, the BR, CFS, BI, KI, and HDS-R scores. Correlations between the CFS and HDS-R score, as well as between the BR and BI or KI, were analyzed using Spearman's rank correlation coefficients.</p><p><strong>Results: </strong>A total of 749 participants were included in the analysis of criterion-related validity between the CFS and HDS-R. In the CFS cohort analysis, 202 patients (27.0%) were categorized as having a normal CFS, and the median HDS-R score was 18 (range: 6-26). The correlation coefficient between the CFS and HDS-R scores was -0.834 (<i>p</i> < 0.001). The correlation coefficient between BR and BI was -0.741 (<i>p</i> < 0.001), BR and KI was -0.740 (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>The CFS revealed significant criterion-related validity compared with the established cognitive assessment scale, the HDS-R. The BR also demonstrated significant criterion-related validity with the BI and KI.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What’s new in dementia risk prediction modelling? An updated systematic review 痴呆症风险预测模型有何新进展?最新系统综述
IF 2.3 Q2 Medicine Pub Date : 2024-06-10 DOI: 10.1159/000539744
Jacob Brain, Aysegul Humeyra Kafadar, Linda Errington, Rachael Kirkley, Eugene Y.H. Tang, R. Akyea, Manpreet Bains, Carol Brayne, Grazziela Figueredo, Leanne Greene, Jennie Louise, Catharine Morgan, Eduwin Pakpahan, David Reeves, Louise Robinson, Amy Salter, Mario Siervo, Phillip J. Tully, Deborah Turnbull, Nadeem Qureshi, Blossom Stephan
IntroductionIdentifying individuals at high risk of dementia is critical to optimized clinical care, formulating effective preventative strategies, and determining eligibility for clinical trials. Since our previous systematic reviews in 2010 and 2015, there has been a surge in dementia risk prediction modelling. The aim of this study is to update our previous reviews to explore, and critically review, new developments in dementia risk modelling.MethodsMEDLINE, Embase, Scopus, and Web of Science were searched from March 2014 to June 2022. Studies were included if they were population or community-based cohorts (including electronic health record data), had developed a model for predicting late-life incident dementia and included model performance indices such as discrimination, calibration, or external validation.Results In total, 9,209 articles were identified from the electronic search, of which 74 met the inclusion criteria. We found a substantial increase in the number of new models published from 2014 (>50 new models), including an increase in the number of models developed using machine learning. Over 450 unique predictor (component) variables have been tested. Nineteen studies (26%) undertook external validation of newly developed or existing models, with mixed results. For the first time, models have also been developed in low- and middle-income countries (LMICs) and others validated in racial and ethnic minority groups. ConclusionThe literature on dementia risk prediction modelling is rapidly evolving with new analytical developments and testing in LMICs. However, it is still challenging to make recommendations about which one model is the most suitable for routine use in a clinical setting. There is an urgent need to develop a suitable, robust, validated risk prediction model in the general population that can be widely implemented in clinical practice to improve dementia prevention.
导言识别痴呆症高风险人群对于优化临床护理、制定有效的预防策略以及确定临床试验资格至关重要。自 2010 年和 2015 年的系统性综述以来,痴呆症风险预测模型的研究激增。本研究旨在更新我们之前的综述,探索并批判性地回顾痴呆症风险建模的新进展。方法检索了2014年3月至2022年6月期间的MEDLINE、Embase、Scopus和Web of Science。如果研究是基于人群或社区的队列(包括电子健康记录数据),已开发出预测晚年痴呆症的模型,并包含模型性能指标,如辨别度、校准或外部验证,则被纳入研究。我们发现,2014 年以来发表的新模型数量大幅增加(超过 50 个新模型),包括使用机器学习开发的模型数量增加。超过 450 个独特的预测(成分)变量得到了测试。19项研究(26%)对新开发或现有模型进行了外部验证,结果喜忧参半。此外,还首次在中低收入国家(LMICs)开发了模型,并在少数种族和少数民族群体中验证了其他模型。结论痴呆症风险预测模型的文献随着新分析方法的开发和在低收入国家的测试而迅速发展。然而,要就哪种模型最适合在临床环境中常规使用提出建议仍具有挑战性。当务之急是在普通人群中开发一种合适的、可靠的、经过验证的风险预测模型,并在临床实践中广泛应用,以改善痴呆症的预防。
{"title":"What’s new in dementia risk prediction modelling? An updated systematic review","authors":"Jacob Brain, Aysegul Humeyra Kafadar, Linda Errington, Rachael Kirkley, Eugene Y.H. Tang, R. Akyea, Manpreet Bains, Carol Brayne, Grazziela Figueredo, Leanne Greene, Jennie Louise, Catharine Morgan, Eduwin Pakpahan, David Reeves, Louise Robinson, Amy Salter, Mario Siervo, Phillip J. Tully, Deborah Turnbull, Nadeem Qureshi, Blossom Stephan","doi":"10.1159/000539744","DOIUrl":"https://doi.org/10.1159/000539744","url":null,"abstract":"Introduction\u0000Identifying individuals at high risk of dementia is critical to optimized clinical care, formulating effective preventative strategies, and determining eligibility for clinical trials. Since our previous systematic reviews in 2010 and 2015, there has been a surge in dementia risk prediction modelling. The aim of this study is to update our previous reviews to explore, and critically review, new developments in dementia risk modelling.\u0000Methods\u0000MEDLINE, Embase, Scopus, and Web of Science were searched from March 2014 to June 2022. Studies were included if they were population or community-based cohorts (including electronic health record data), had developed a model for predicting late-life incident dementia and included model performance indices such as discrimination, calibration, or external validation.\u0000Results \u0000In total, 9,209 articles were identified from the electronic search, of which 74 met the inclusion criteria. We found a substantial increase in the number of new models published from 2014 (>50 new models), including an increase in the number of models developed using machine learning. Over 450 unique predictor (component) variables have been tested. Nineteen studies (26%) undertook external validation of newly developed or existing models, with mixed results. For the first time, models have also been developed in low- and middle-income countries (LMICs) and others validated in racial and ethnic minority groups. \u0000Conclusion\u0000The literature on dementia risk prediction modelling is rapidly evolving with new analytical developments and testing in LMICs. However, it is still challenging to make recommendations about which one model is the most suitable for routine use in a clinical setting. There is an urgent need to develop a suitable, robust, validated risk prediction model in the general population that can be widely implemented in clinical practice to improve dementia prevention.","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141362332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Depressive symptoms are not associated with predementia CSF amyloid pathology 抑郁症状与痴呆前脑脊液淀粉样病理无关
IF 2.3 Q2 Medicine Pub Date : 2024-05-10 DOI: 10.1159/000539284
C. Eriksson, Bjørn-Eivind Kirsebom, Ragna Espenes, N. Siafarikas, K. Waterloo, A. Rongve, P. Selnes, Dag Aarsland, T. Fladby, Erik Hessen
ABSTRACTINTRODUCTION: Depressive symptoms are associated with Alzheimer’s disease (AD), but their neurobiological and neuropsychological correlates remain poorly understood. We investigate if depressive symptoms are associated with amyloid (Aβ) pathology and cognition in predementia AD. METHODS: We included Subjective Cognitive Decline (SCD, n= 160) and Mild Cognitive Impairment (MCI, n=192) from the Dementia Disease Initiation cohort. Depressive symptoms were assessed using the Geriatric Depression Scale (GDS-15). Aβ pathology was determined using cerebrospinal fluid (CSF) Aβ42/40 ratio. Associations between depressive symptoms and cognition were assessed with logistic regression. RESULTS: Only the Aβ negative MCI group (MCI-Aβ-) was associated with depressive symptoms (OR=2.65, p=.005). Depressive symptoms were associated with worse memory in MCI-Aβ- (OR=0.94, p=.039), but with better performance in MCI-Aβ+ (OR=1.103, p=.001). DISCUSSION: Our results suggest that depressive symptoms in MCI are neither associated with Aβ pathology, nor AD-associated memory impairment. However, memory impairment in non-AD MCI may relate to depressive symptoms.
摘要:抑郁症状与阿尔茨海默病(AD)有关,但其神经生物学和神经心理学相关性仍鲜为人知。我们研究了抑郁症状是否与痴呆前期阿尔茨海默病的淀粉样蛋白(Aβ)病理和认知相关。方法:我们纳入了痴呆症起始队列中的主观认知功能减退(SCD,人数=160)和轻度认知功能障碍(MCI,人数=192)患者。抑郁症状采用老年抑郁量表(GDS-15)进行评估。通过脑脊液(CSF)Aβ42/40比值确定Aβ病理学。抑郁症状与认知能力之间的关系通过逻辑回归进行评估。结果:只有 Aβ 阴性 MCI 组(MCI-Aβ-)与抑郁症状相关(OR=2.65,p=.005)。抑郁症状与 MCI-Aβ- 组记忆力较差有关(OR=0.94,p=.039),但与 MCI-Aβ+ 组记忆力较好有关(OR=1.103,p=.001)。讨论:我们的研究结果表明,MCI患者的抑郁症状既与Aβ病理学无关,也与AD相关的记忆损伤无关。然而,非 AD MCI 患者的记忆损伤可能与抑郁症状有关。
{"title":"Depressive symptoms are not associated with predementia CSF amyloid pathology","authors":"C. Eriksson, Bjørn-Eivind Kirsebom, Ragna Espenes, N. Siafarikas, K. Waterloo, A. Rongve, P. Selnes, Dag Aarsland, T. Fladby, Erik Hessen","doi":"10.1159/000539284","DOIUrl":"https://doi.org/10.1159/000539284","url":null,"abstract":"ABSTRACT\u0000INTRODUCTION: Depressive symptoms are associated with Alzheimer’s disease (AD), but their neurobiological and neuropsychological correlates remain poorly understood. We investigate if depressive symptoms are associated with amyloid (Aβ) pathology and cognition in predementia AD. \u0000METHODS: We included Subjective Cognitive Decline (SCD, n= 160) and Mild Cognitive Impairment (MCI, n=192) from the Dementia Disease Initiation cohort. Depressive symptoms were assessed using the Geriatric Depression Scale (GDS-15). Aβ pathology was determined using cerebrospinal fluid (CSF) Aβ42/40 ratio. Associations between depressive symptoms and cognition were assessed with logistic regression. \u0000RESULTS: Only the Aβ negative MCI group (MCI-Aβ-) was associated with depressive symptoms (OR=2.65, p=.005). Depressive symptoms were associated with worse memory in MCI-Aβ- (OR=0.94, p=.039), but with better performance in MCI-Aβ+ (OR=1.103, p=.001). \u0000DISCUSSION: Our results suggest that depressive symptoms in MCI are neither associated with Aβ pathology, nor AD-associated memory impairment. However, memory impairment in non-AD MCI may relate to depressive symptoms. \u0000","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140991144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Relation of Sleep Characteristics and Cognitive Impairment in Community-Dwelling Middle-Aged and Older Adults: Ardakan Cohort Study on Aging (ACSA). 社区中老年人的睡眠特征与认知障碍的关系:阿尔达坎老龄化队列研究》(ACSA)。
IF 1.4 Q4 CLINICAL NEUROLOGY Pub Date : 2024-04-29 eCollection Date: 2024-01-01 DOI: 10.1159/000539060
Ahmad Delbari, Fatemeh Sadat Tabatabaei, Payam Jannatdoust, Amirali Azimi, Mohammad Bidkhori, Mohammad Saatchi, Mahshid Foroughan, Elham Hooshmand

Introduction: The rise in the elderly population has brought attention to mild cognitive impairment (MCI). Sleep disorders also affect many older adults, indicating an important area of research for disturbed sleep and faster brain aging. This population-based study aimed to investigate the association of several sleep indicators with cognitive performance.

Methods: This cross-sectional study focused on adults over 50 in the Ardakan Cohort Study on Aging (ACSA). MCI was evaluated using the Mini-Mental State Examination (MMSE) and the Abbreviated Mental Test score (AMTS) in literate and illiterate individuals. Sleep characteristics were collected using the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale, and Berlin questionnaire. The logistic regression models were used to analyze the data.

Results: Overall, 3,380 literate and 1,558 illiterate individuals were included. In both groups, participants with MCI had a significantly higher PSQI global score (p < 0.05). Also, among the literate individuals, a significantly higher risk of having sleep-disordered breathing and poor sleep quality was observed in participants with MCI (p < 0.05). In illiterate individuals, higher sleep latency than 15 min increased odds of MCI (p < 0.05). However, after adjusting for all variables, only literate individuals with a sleep duration of more than 8 h had 66 percent increased odds of having MCI (p = 0.033).

Conclusion: Sleep duration might be associated with cognitive function in the older Iranian population. Our findings underscore the importance of considering sleep patterns in relation to cognitive health.

简介老年人口的增加引起了人们对轻度认知障碍(MCI)的关注。睡眠障碍也影响着许多老年人,这表明睡眠紊乱和大脑加速衰老是一个重要的研究领域。这项基于人群的研究旨在调查几项睡眠指标与认知能力的关系:这项横断面研究主要针对阿尔达坎老龄队列研究(ACSA)中 50 岁以上的成年人。在识字和不识字的人群中,使用迷你精神状态检查(MMSE)和简短智力测验得分(AMTS)对 MCI 进行评估。使用匹兹堡睡眠质量指数(PSQI)、爱普沃斯嗜睡量表和柏林问卷调查收集睡眠特征。采用逻辑回归模型对数据进行分析:研究共纳入了 3380 名识字者和 1558 名文盲。两组中,MCI 患者的 PSQI 总分都明显较高(P < 0.05)。此外,在识字者中,患有 MCI 的参与者出现睡眠呼吸紊乱和睡眠质量差的风险明显更高(p < 0.05)。在文盲中,睡眠潜伏期高于 15 分钟会增加 MCI 的几率(p < 0.05)。然而,在对所有变量进行调整后,只有睡眠时间超过8小时的文盲患MCI的几率增加了66%(p = 0.033):结论:睡眠时间可能与伊朗老年人群的认知功能有关。我们的研究结果强调了考虑睡眠模式与认知健康关系的重要性。
{"title":"The Relation of Sleep Characteristics and Cognitive Impairment in Community-Dwelling Middle-Aged and Older Adults: Ardakan Cohort Study on Aging (ACSA).","authors":"Ahmad Delbari, Fatemeh Sadat Tabatabaei, Payam Jannatdoust, Amirali Azimi, Mohammad Bidkhori, Mohammad Saatchi, Mahshid Foroughan, Elham Hooshmand","doi":"10.1159/000539060","DOIUrl":"https://doi.org/10.1159/000539060","url":null,"abstract":"<p><strong>Introduction: </strong>The rise in the elderly population has brought attention to mild cognitive impairment (MCI). Sleep disorders also affect many older adults, indicating an important area of research for disturbed sleep and faster brain aging. This population-based study aimed to investigate the association of several sleep indicators with cognitive performance.</p><p><strong>Methods: </strong>This cross-sectional study focused on adults over 50 in the Ardakan Cohort Study on Aging (ACSA). MCI was evaluated using the Mini-Mental State Examination (MMSE) and the Abbreviated Mental Test score (AMTS) in literate and illiterate individuals. Sleep characteristics were collected using the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale, and Berlin questionnaire. The logistic regression models were used to analyze the data.</p><p><strong>Results: </strong>Overall, 3,380 literate and 1,558 illiterate individuals were included. In both groups, participants with MCI had a significantly higher PSQI global score (<i>p</i> < 0.05). Also, among the literate individuals, a significantly higher risk of having sleep-disordered breathing and poor sleep quality was observed in participants with MCI (<i>p</i> < 0.05). In illiterate individuals, higher sleep latency than 15 min increased odds of MCI (<i>p</i> < 0.05). However, after adjusting for all variables, only literate individuals with a sleep duration of more than 8 h had 66 percent increased odds of having MCI (<i>p</i> = 0.033).</p><p><strong>Conclusion: </strong>Sleep duration might be associated with cognitive function in the older Iranian population. Our findings underscore the importance of considering sleep patterns in relation to cognitive health.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11208999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of age-related hearing loss on working memory among older individuals: An event-related potential study 与年龄相关的听力损失对老年人工作记忆的影响:事件相关电位研究
IF 2.3 Q2 Medicine Pub Date : 2024-03-12 DOI: 10.1159/000538109
Sankalpa Madashetty, Hari Palaniswamy, Bellur Rajashekhar
Introduction:Age-related hearing loss (ARHL) may affect working memory (WM), which impacts problem-solving, decision-making, language comprehension, and learning. Limited research exists on how ARHL affects working memory using N-Back tasks, but studying this is crucial for understanding neural markers and associated cognitive processes. Our study explores the impact of ARHL on WM using behavioral and electrophysiological measures and how it correlates with speech-in-noise scores in older individuals with ARHL. Method:The study involved two groups, each with 20 participants aged 60 to 80. Group 1 had individuals with mild to moderate sensorineural hearing loss, while Group 2 had age and education-matched controls with normal or near-normal hearing. Participants underwent audiological assessments and completed cognitive tests, including simple reaction time and N-back tests. During the performance of cognitive tasks, a simultaneous electroencephalography was recorded. Data analysis included behavioral and event-related potentials, source estimation, and functional connectivity analysis. Results:The study revealed significantly poor accuracy, longer reaction time, and smaller P300 amplitude among individuals with ARHL, even after controlling for general slowing. Individuals with ARHL experience compromised neural activity, particularly in the temporal and parietal regions, which are vital for cognition and WM. Furthermore, individuals with ARHL exhibited poor communication between the superior temporal gyrus and insulae regions among the brain regions mediating WM during the 1-back task. Also, the study found a strong correlation between hearing measures and working memory outcomes. Conclusion:The study findings suggest that individuals with ARHL have impaired WM compared to those with normal hearing. This indicates a potential link between ARHL and cognitive decline, which could significantly affect daily life and quality of life. The widely used WM test with simultaneous EEG recording and source estimation analysis would further validate the usefulness of the study in assessing WM in this population.
导言:年龄相关性听力损失(ARHL)可能会影响工作记忆(WM),而工作记忆会影响问题解决、决策、语言理解和学习。有关 ARHL 如何通过 N-Back 任务影响工作记忆的研究十分有限,但研究这一点对于了解神经标记和相关认知过程至关重要。我们的研究使用行为和电生理测量方法探讨了 ARHL 对 WM 的影响,以及它与患有 ARHL 的老年人的噪声语音分数之间的相关性。研究方法:研究分为两组,每组 20 人,年龄在 60 至 80 岁之间。第一组为轻度至中度感音神经性听力损失患者,第二组为听力正常或接近正常的年龄和教育程度相匹配的对照组。参与者接受了听力评估,并完成了认知测试,包括简单反应时间和N-back测试。在完成认知任务的过程中,同步记录了脑电图。数据分析包括行为和事件相关电位、源估计和功能连接分析。结果:研究发现,即使在控制了全身反应迟钝的情况下,ARHL 患者的准确性也明显较差,反应时间较长,P300 振幅较小。ARHL患者的神经活动受到影响,尤其是在对认知和WM至关重要的颞叶和顶叶区域。此外,ARHL 患者的颞上回和胰岛区域之间的沟通能力较差,而胰岛区域是 "1-back "任务中介导 WM 的大脑区域。研究还发现,听力测量结果与工作记忆结果之间存在很强的相关性。结论:研究结果表明,与听力正常的人相比,ARHL 患者的 WM 能力受损。这表明 ARHL 与认知能力下降之间存在潜在联系,而认知能力下降可能会严重影响日常生活和生活质量。广泛使用的 WM 测试与同步脑电图记录和源估分析将进一步验证本研究在评估该人群 WM 方面的实用性。
{"title":"The impact of age-related hearing loss on working memory among older individuals: An event-related potential study","authors":"Sankalpa Madashetty, Hari Palaniswamy, Bellur Rajashekhar","doi":"10.1159/000538109","DOIUrl":"https://doi.org/10.1159/000538109","url":null,"abstract":"Introduction:\u0000Age-related hearing loss (ARHL) may affect working memory (WM), which impacts problem-solving, decision-making, language comprehension, and learning. Limited research exists on how ARHL affects working memory using N-Back tasks, but studying this is crucial for understanding neural markers and associated cognitive processes. Our study explores the impact of ARHL on WM using behavioral and electrophysiological measures and how it correlates with speech-in-noise scores in older individuals with ARHL. \u0000Method:\u0000The study involved two groups, each with 20 participants aged 60 to 80. Group 1 had individuals with mild to moderate sensorineural hearing loss, while Group 2 had age and education-matched controls with normal or near-normal hearing. Participants underwent audiological assessments and completed cognitive tests, including simple reaction time and N-back tests. During the performance of cognitive tasks, a simultaneous electroencephalography was recorded. Data analysis included behavioral and event-related potentials, source estimation, and functional connectivity analysis. \u0000Results:\u0000The study revealed significantly poor accuracy, longer reaction time, and smaller P300 amplitude among individuals with ARHL, even after controlling for general slowing. Individuals with ARHL experience compromised neural activity, particularly in the temporal and parietal regions, which are vital for cognition and WM. Furthermore, individuals with ARHL exhibited poor communication between the superior temporal gyrus and insulae regions among the brain regions mediating WM during the 1-back task. Also, the study found a strong correlation between hearing measures and working memory outcomes. \u0000Conclusion:\u0000The study findings suggest that individuals with ARHL have impaired WM compared to those with normal hearing. This indicates a potential link between ARHL and cognitive decline, which could significantly affect daily life and quality of life. The widely used WM test with simultaneous EEG recording and source estimation analysis would further validate the usefulness of the study in assessing WM in this population.","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140250978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary microgliopathy presenting as degenerative dementias: A case series of novel gene mutations from India 原发性小胶质细胞病表现为退行性痴呆:印度新型基因突变病例系列
IF 2.3 Q2 Medicine Pub Date : 2024-03-08 DOI: 10.1159/000538145
S. Ramakrishnan, F. Arshad, Keerthana Bs, Arun Gokul Pon, Susan Bosco, Sandeep Kumar, Hariharakrishnan Chidambaram, Subhash Chandra Bose Chinnathambi, Karthik Kulanthaivelu, Gautham Arunachal, S. Alladi
IntroductionMicroglia exert a crucial role in homeostasis of white matter integrity and several studies highlight the role of microglial dysfunctions in neurodegeneration. Primary microgliopathy are disorders where the pathogenic abnormality of the microglia causes white matter disorder and leads to a neuropsychiatric diseases. Triggering Receptor Expressed on Myeloid Cells (TREM2), TYRO protein tyrosine kinase binding protein (TYROBP), Colony-stimulating factor 1 receptor (CSF1R) are genes implicated in primary microgliopathy. Clinical manifestations of primary microgliopathy are myriad ranging from neuropsychiatric syndrome, motor disability, gait dysfunction, ataxia, pure dementia, frontotemporal dementia, Alzheimer dementia and so on. It becomes imperative to establish diagnosis of microgliopathy masquerading as degenerative dementia, especially with promising therapies on horizon for the same. We aim to describe a case series of subjects with dementia harboring novel genes of primary microgliopathy, along with their clinical, neuropsychological, and cognitive profile and radiological patterns.Methods: The prospective study was conducted in a university referral hospital in South India, as a part of an ongoing clinic-genetic research on Dementia subjects and was approved by the institutional ethics committee. All patients underwent detailed assessment including socio demographic profile, clinical and cognitive assessment, pedigree analysis and comprehensive neurological examination. Subjects consenting for blood sampling underwent genetic testing by Whole exome sequencing (WES).Results: 100 patients of dementia underwent genetic analysis using whole exome sequencing and three pathogenic variants, one each of TREM2, TYROBP and CSF1R and two variants of uncertain significance in CSF1R were identified as cause of primary microgliopathy .TREM 2 and TYROBP presented as frontotemporal syndrome whereas CSF1R presented as frontotemporal syndrome and Alzheimer dementia.Conclusion :WES has widened the spectrum of underlying neuropathology of degenerative dementias and diagnosing primary microglial dysfunction with emerging therapeutic options is of paramount importance. Cases of primary microgliopathy due to Novel mutations in TREM2, TYROBP and CSF1R with phenotype of degenerative dementia are being first time reported from Indian cohort.Our study enriches the spectrum of genetic variants implicated in degenerative dementia, and provides the basis for exploring complex molecular mechanisms like microglial dysfunction, as underlying cause for neurodegeneration.
导言小胶质细胞在白质完整性的平衡中发挥着至关重要的作用,一些研究强调了小胶质细胞功能障碍在神经退行性病变中的作用。原发性小胶质细胞病是指小胶质细胞的致病性异常导致白质紊乱并引发神经精神疾病的疾病。髓系细胞上表达的触发受体(TREM2)、TYRO蛋白酪氨酸激酶结合蛋白(TYROBP)和集落刺激因子1受体(CSF1R)是与原发性小胶质细胞病有关的基因。原发性小神经胶质细胞病的临床表现多种多样,包括神经精神综合征、运动障碍、步态功能障碍、共济失调、单纯性痴呆、额颞叶痴呆、阿尔茨海默性痴呆等。当务之急是对伪装成退行性痴呆的微神经胶质细胞病变进行诊断,尤其是在该病的治疗前景看好的情况下。我们旨在描述一系列携带原发性微神经胶质细胞病变新型基因的痴呆症患者的病例,以及他们的临床、神经心理学、认知概况和放射学模式:这项前瞻性研究在印度南部的一家大学转诊医院进行,是正在进行的痴呆症临床基因研究的一部分,并获得了机构伦理委员会的批准。所有患者都接受了详细的评估,包括社会人口概况、临床和认知评估、血统分析和全面的神经系统检查。同意抽血的受试者接受了全外显子组测序(WES)基因检测:结果:100 名痴呆症患者接受了全外显子组测序的基因分析,确定了 TREM2、TYROBP 和 CSF1R 的三个致病变异以及 CSF1R 的两个意义不明的变异是原发性微神经胶质病的病因。TREM2和TYROBP表现为额颞叶综合征,而CSF1R则表现为额颞叶综合征和阿尔茨海默痴呆。我们的研究丰富了与退行性痴呆有关的基因变异的范围,为探索复杂的分子机制(如微神经胶质细胞功能障碍)提供了基础,而微神经胶质细胞功能障碍是导致神经退行性痴呆的根本原因。
{"title":"Primary microgliopathy presenting as degenerative dementias: A case series of novel gene mutations from India","authors":"S. Ramakrishnan, F. Arshad, Keerthana Bs, Arun Gokul Pon, Susan Bosco, Sandeep Kumar, Hariharakrishnan Chidambaram, Subhash Chandra Bose Chinnathambi, Karthik Kulanthaivelu, Gautham Arunachal, S. Alladi","doi":"10.1159/000538145","DOIUrl":"https://doi.org/10.1159/000538145","url":null,"abstract":"Introduction\u0000Microglia exert a crucial role in homeostasis of white matter integrity and several studies highlight the role of microglial dysfunctions in neurodegeneration. Primary microgliopathy are disorders where the pathogenic abnormality of the microglia causes white matter disorder and leads to a neuropsychiatric diseases. Triggering Receptor Expressed on Myeloid Cells (TREM2), TYRO protein tyrosine kinase binding protein (TYROBP), Colony-stimulating factor 1 receptor (CSF1R) are genes implicated in primary microgliopathy. Clinical manifestations of primary microgliopathy are myriad ranging from neuropsychiatric syndrome, motor disability, gait dysfunction, ataxia, pure dementia, frontotemporal dementia, Alzheimer dementia and so on. It becomes imperative to establish diagnosis of microgliopathy masquerading as degenerative dementia, especially with promising therapies on horizon for the same.\u0000 We aim to describe a case series of subjects with dementia harboring novel genes of primary microgliopathy, along with their clinical, neuropsychological, and cognitive profile and radiological patterns.\u0000Methods: The prospective study was conducted in a university referral hospital in South India, as a part of an ongoing clinic-genetic research on Dementia subjects and was approved by the institutional ethics committee. All patients underwent detailed assessment including socio demographic profile, clinical and cognitive assessment, pedigree analysis and comprehensive neurological examination. Subjects consenting for blood sampling underwent genetic testing by Whole exome sequencing (WES).\u0000Results: 100 patients of dementia underwent genetic analysis using whole exome sequencing and three pathogenic variants, one each of TREM2, TYROBP and CSF1R and two variants of uncertain significance in CSF1R were identified as cause of primary microgliopathy .TREM 2 and TYROBP presented as frontotemporal syndrome whereas CSF1R presented as frontotemporal syndrome and Alzheimer dementia.\u0000Conclusion :WES has widened the spectrum of underlying neuropathology of degenerative dementias and diagnosing primary microglial dysfunction with emerging therapeutic options is of paramount importance. Cases of primary microgliopathy due to Novel mutations in TREM2, TYROBP and CSF1R with phenotype of degenerative dementia are being first time reported from Indian cohort.\u0000Our study enriches the spectrum of genetic variants implicated in degenerative dementia, and provides the basis for exploring complex molecular mechanisms like microglial dysfunction, as underlying cause for neurodegeneration.\u0000","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140076916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Psychosocial Intervention for Carers of Individuals Diagnosed with Dementia in Social Isolation. 为处于社会隔离状态的被诊断为痴呆症患者的照护者提供社会心理干预。
IF 2.3 Q2 Medicine Pub Date : 2023-11-18 eCollection Date: 2023-01-01 DOI: 10.1159/000535207
Grace Wei, Olivier Piguet, Fiona Kumfor

Introduction: Growing research has shown the negative impact of social isolation on the health and psychological well-being of individuals with dementia and their carers. This study investigated the effectiveness of a psychosocial intervention for dementia carers during a lockdown period of the COVID-19 pandemic.

Methods: Twenty-three family carers of individuals diagnosed with dementia living in the community were recruited and provided with an online psychoeducation toolkit that aims to improve health literacy, management of social and behavioural symptoms in dementia, carer social engagement, and coping skills. Carers were divided into "mild" or "moderate" groups based on the disease severity of the person with dementia they cared for. Outcome measures including distress and severity of neuropsychiatric symptoms, carer self-efficacy and burden, social network, and feelings of loneliness were assessed at baseline and 2 weeks later.

Results: Carers in the moderate group reported higher levels of distress (p = 0.001) and severity (p < 0.001) of neuropsychiatric symptoms and greater carer burden (p = 0.003) than carers in the mild group. Following the intervention, both groups reported increased social networks (p = 0.001). In addition, carers in the moderate group reported significantly reduced distress for neuropsychiatric symptoms (p = 0.013), enhanced carer self-efficacy for controlling upsetting thoughts (p = 0.040), and decreased loneliness (p = 0.023).

Conclusions: This study demonstrated that psychosocial interventions improve outcomes for carers of individuals with dementia, particularly those caring for individuals with greater disease severity. Findings from this study will inform the development of support services that meet the evolving needs of individuals with dementia and their carers in social isolation, during and in a post-pandemic context.

导言:越来越多的研究表明,社会隔离对痴呆症患者及其照护者的健康和心理健康有负面影响。本研究调查了在 COVID-19 大流行封锁期间对痴呆症照护者进行社会心理干预的效果:研究招募了 23 名在社区生活的被确诊为痴呆症患者的家庭照护者,并为他们提供了一个在线心理教育工具包,旨在提高他们的健康素养、痴呆症的社会和行为症状管理、照护者的社会参与和应对技能。根据照护者所照护的痴呆症患者的病情严重程度,照护者被分为 "轻度 "和 "中度 "两组。在基线和两周后对结果进行评估,包括神经精神症状的痛苦和严重程度、照护者的自我效能感和负担、社交网络和孤独感:与轻度组的照护者相比,中度组照护者的神经精神症状的痛苦程度(p = 0.001)和严重程度(p < 0.001)更高,照护者的负担(p = 0.003)更大。干预后,两组照护者都表示社交网络有所增加(p = 0.001)。此外,中度组的照护者表示神经精神症状的困扰明显减轻(p = 0.013),照护者控制烦躁想法的自我效能得到提高(p = 0.040),孤独感减少(p = 0.023):本研究表明,社会心理干预可改善痴呆症患者照护者的疗效,尤其是那些照护病情较重患者的照护者。这项研究的结果将为支持服务的发展提供参考,以满足社会隔离期间和大流行后痴呆症患者及其照护者不断变化的需求。
{"title":"A Psychosocial Intervention for Carers of Individuals Diagnosed with Dementia in Social Isolation.","authors":"Grace Wei, Olivier Piguet, Fiona Kumfor","doi":"10.1159/000535207","DOIUrl":"10.1159/000535207","url":null,"abstract":"<p><strong>Introduction: </strong>Growing research has shown the negative impact of social isolation on the health and psychological well-being of individuals with dementia and their carers. This study investigated the effectiveness of a psychosocial intervention for dementia carers during a lockdown period of the COVID-19 pandemic.</p><p><strong>Methods: </strong>Twenty-three family carers of individuals diagnosed with dementia living in the community were recruited and provided with an online psychoeducation toolkit that aims to improve health literacy, management of social and behavioural symptoms in dementia, carer social engagement, and coping skills. Carers were divided into \"mild\" or \"moderate\" groups based on the disease severity of the person with dementia they cared for. Outcome measures including distress and severity of neuropsychiatric symptoms, carer self-efficacy and burden, social network, and feelings of loneliness were assessed at baseline and 2 weeks later.</p><p><strong>Results: </strong>Carers in the moderate group reported higher levels of distress (<i>p</i> = 0.001) and severity (<i>p</i> < 0.001) of neuropsychiatric symptoms and greater carer burden (<i>p</i> = 0.003) than carers in the mild group. Following the intervention, both groups reported increased social networks (<i>p</i> = 0.001). In addition, carers in the moderate group reported significantly reduced distress for neuropsychiatric symptoms (<i>p</i> = 0.013), enhanced carer self-efficacy for controlling upsetting thoughts (<i>p</i> = 0.040), and decreased loneliness (<i>p</i> = 0.023).</p><p><strong>Conclusions: </strong>This study demonstrated that psychosocial interventions improve outcomes for carers of individuals with dementia, particularly those caring for individuals with greater disease severity. Findings from this study will inform the development of support services that meet the evolving needs of individuals with dementia and their carers in social isolation, during and in a post-pandemic context.</p>","PeriodicalId":38017,"journal":{"name":"Dementia and Geriatric Cognitive Disorders Extra","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10721235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Dementia and Geriatric Cognitive Disorders Extra
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1