Impact of Some Immunological Parameters (antioxidant – cytokines) in Cutaneous leishmaniasis in a Sample of Patients in the Al-Ramadi City.

Othman M. Mohammad, thaer A. SALIH, Mohammad M. Al-Halbosiy
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Abstract

Background: Cutaneous leishmaniasis is one of the endemic diseases in Iraq. Both types of cutaneous leishmaniasis that cause different ulcers are present, namely Leishmania major and Leishmania tropica, The disease also represents a major public and global health problem all over the world. Objective: Investigation of the relationship between parasitic infection with cutaneous leishmaniasis and some antioxidants Superoxide, Nitric oxide and immune cytokines tumor necrosis factor-alpha, Interferon-gamma. Materials and Methods: The demographic and epidemiological study included 55 cases suspected of being infected with cutaneous leishmaniasis. They visited Ramadi Teaching Hospital, with 25 volunteers. After obtaining their consent, they were used as control samples, where blood serum samples were obtained from both study groups. After that, work was done in laboratories. Department of Biology - College of Education for Pure Sciences - Anbar University. Results: The patients and healthy people were of different genders, and among the 55 samples from the infected, the number of males was 36 (65.5)% and females 19 (34.5)%, with statistically significant differences p<0.05, and the age groups of the patients were from one year to 60 years. With an average age of (31 years), they were distributed into 6 groups. Also, among the 25 samples from the control group, the number of males was 12 (48%) and females were 13 (52%), Their ages also ranged from one year to 60 years, with an average age of (13) years, the enzyme-linked immunoabsorbent assay (ELISA) technique was used to detect the level of immunological indicators TNF-α, IFN-γ, SOD, NO, where the results showed High levels in the serum of cutaneous leishmaniasis patients (120.00 ± 52.11, 123.00 ± 44.21, 3.10 ± 1.21 and 121.93 ± 33.22), respectively compared to healthy subjects (72.86 ± 14.94, 21.91 ± 45.40, 0.88 ± 0.12, and 81.46 ± 4.50 ) respectively With statistically significant differences at the level of p < 0.05, p < 0.001. Conclusions: The inflammatory cytokines TNF-α, IFN-γ play a vital role in increasing or decreasing the severity in the pathogenesis of the disease and eliminating it.
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一些免疫参数(抗氧化剂-细胞因子)对 Al-Ramadi 市皮肤利什曼病患者样本的影响。
背景:皮肤利什曼病是伊拉克的地方病之一:皮肤利什曼病是伊拉克的地方病之一。两种类型的皮肤利什曼病都会导致不同的溃疡,即大利什曼病和热带利什曼病。目标:调查寄生虫感染与溃疡之间的关系调查皮肤利什曼病寄生虫感染与一些抗氧化剂超氧化物、一氧化氮和免疫细胞因子肿瘤坏死因子-α、干扰素-γ之间的关系。材料与方法:人口统计学和流行病学研究包括 55 例疑似感染皮肤利什曼病的病例。他们与 25 名志愿者一起前往拉马迪教学医院。在征得他们的同意后,将他们作为对照样本,从两个研究组中获取血清样本。之后,工作在实验室进行。安巴尔大学纯科学教育学院生物系。研究结果在 55 份感染者样本中,男性占 36 (65.5)%,女性占 19 (34.5)%,差异有统计学意义(P<0.05)。患者年龄组从 1 岁到 60 岁不等,平均年龄为 31 岁,共分为 6 组。采用酶联免疫吸附试验(ELISA)技术检测皮肤利什曼病患者血清中免疫指标 TNF-α、IFN-γ、SOD、NO 的水平,结果显示皮肤利什曼病患者血清中 TNF-α、IFN-γ、SOD、NO 含量较高(120.00 ± 52.11、123.00 ± 44.21、3.10 ± 1.21 和 121.93 ± 33.22),分别高于健康受试者(72.86 ± 14.94、21.91 ± 45.40、0.88 ± 0.12 和 81.46 ± 4.50)。结论炎性细胞因子 TNF-α、IFN-γ 在疾病的发病机制中起着重要的增减和消除作用。
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