Highly Biocompatible Hemoglobin-Stabilized Gold Nanoparticles for an Enhanced Catalytic Reduction of 4-Nitrophenol

Inorganics Pub Date : 2024-05-05 DOI:10.3390/inorganics12050136

Yanshuai Cui, Shukai Li, Ning Yu, Xiaodong Yu, Xianbing Ji, Longgang Wang

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Abstract

4-nitrophenol (4-NP) is a frequently encountered toxic phenolic organic pollutant in water. It is important to develop a simple method to treat 4-NP. Small and monodispersed gold nanoparticles often have good catalytic performance of 4-NP. Hemoglobin (Hb) is a kind of common and important protein in organisms. Herein, highly biocompatible bovine hemoglobin-stabilized gold nanoparticles (Aun-Hb NPs) were synthesized using hemoglobin as a biological template. Then, the size, zeta potential, and composition of Aun-Hb NPs were investigated by transmission electron microscopy, dynamic light scattering, and X-ray photoelectron spectroscopy. The Aun-Hb NPs with small gold nanoparticles of about 1.4–2.4 nm had good catalytic capabilities in reducing 4-NP to form 4-aminophenol. Au20-Hb NPs demonstrated superior catalytic efficiency in the reduction of 4-NP when compared to other nanoparticles. Moreover, as-synthesized Au20-Hb NPs exhibited excellent biocompatibility through the MTT experiment. The method of preparation of gold nanoparticles offers one way to prepare metal nanoparticles for good potential catalytic applications of gold nanoparticles.

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用于增强 4-硝基苯酚催化还原的高生物相容性血红蛋白稳定金纳米粒子

4-硝基苯酚（4-NP）是水中经常出现的一种有毒酚类有机污染物。开发一种处理 4-NP 的简单方法非常重要。小而单分散的金纳米粒子通常对 4-NP 具有良好的催化性能。血红蛋白（Hb）是生物体内一种常见的重要蛋白质。本文以血红蛋白为生物模板，合成了高生物相容性的牛血红蛋白稳定金纳米颗粒（Aun-Hb NPs）。然后，利用透射电子显微镜、动态光散射和 X 射线光电子能谱对 Aun-Hb NPs 的尺寸、ZETA 电位和组成进行了研究。结果表明，具有约 1.4-2.4 nm 小金纳米颗粒的 Aun-Hb NPs 在还原 4-NP 生成 4-aminophenol 方面具有良好的催化能力。与其他纳米粒子相比，Au20-Hb NPs 在还原 4-NP 的过程中表现出更高的催化效率。此外，通过 MTT 实验，合成的 Au20-Hb NPs 表现出良好的生物相容性。金纳米粒子的制备方法为制备金属纳米粒子提供了一种途径，使金纳米粒子具有良好的催化应用潜力。

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Inorganics

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