Pub Date : 2024-06-04DOI: 10.3390/inorganics12060160
Oana Silvana Sarău, E. Moacă, Alexandra Semenescu, Raluca Dumitru, Alex-Robert Jîjie, Marioara Poenaru, C. Dehelean, A. Chevereșan
Silver nanoparticles (AgNPs) were successfully synthesized via the biological route using a 1 M silver nitrate (AgNO3) aqueous solution and an ethanolic peel extract of Punica granatum (Pg), at 60 °C. The physicochemical analysis revealed the formation of green synthesized Pg-AgNPs with a semi-spherical shape, non-uniformly distributed, and a particle size distribution between 5 and 100 nm. As regards the preliminary in vitro toxicological screening, the green synthesized Pg-AgNPs did not significantly affect the neonatal BALB/c epidermal cells’ viability (JB6 Cl 41-5a) at lower concentrations and did not produce visible changes in the morphology of the JB6 Cl 41-5a cells. In contrast, at higher concentrations (>50 μg/mL), the green Pg-AgNPs exhibited an important decrease in cell viability and confluency. In addition, the impact of Pg-AgNPs on cell membrane integrity suggests a potential cytotoxic effect. Contrary to the in vitro assays, after the evaluation of the anti-irritant effect in ovo, the lower concentration of Pg-AgNPs (10 μg/mL) produced hemorrhage and lysis when applied to the chorioallantoic membrane, while at 50 μg/mL, only slight coagulation was observed. Therefore, regarding the in ovo toxicological screening, the higher concentration of the Pg-AgNPs exhibited a better safety profile compared to the lower concentration, as indicated by the irritation score.
{"title":"Physicochemical and Toxicological Screening of Silver Nanoparticle Biosynthesis from Punica granatum Peel Extract","authors":"Oana Silvana Sarău, E. Moacă, Alexandra Semenescu, Raluca Dumitru, Alex-Robert Jîjie, Marioara Poenaru, C. Dehelean, A. Chevereșan","doi":"10.3390/inorganics12060160","DOIUrl":"https://doi.org/10.3390/inorganics12060160","url":null,"abstract":"Silver nanoparticles (AgNPs) were successfully synthesized via the biological route using a 1 M silver nitrate (AgNO3) aqueous solution and an ethanolic peel extract of Punica granatum (Pg), at 60 °C. The physicochemical analysis revealed the formation of green synthesized Pg-AgNPs with a semi-spherical shape, non-uniformly distributed, and a particle size distribution between 5 and 100 nm. As regards the preliminary in vitro toxicological screening, the green synthesized Pg-AgNPs did not significantly affect the neonatal BALB/c epidermal cells’ viability (JB6 Cl 41-5a) at lower concentrations and did not produce visible changes in the morphology of the JB6 Cl 41-5a cells. In contrast, at higher concentrations (>50 μg/mL), the green Pg-AgNPs exhibited an important decrease in cell viability and confluency. In addition, the impact of Pg-AgNPs on cell membrane integrity suggests a potential cytotoxic effect. Contrary to the in vitro assays, after the evaluation of the anti-irritant effect in ovo, the lower concentration of Pg-AgNPs (10 μg/mL) produced hemorrhage and lysis when applied to the chorioallantoic membrane, while at 50 μg/mL, only slight coagulation was observed. Therefore, regarding the in ovo toxicological screening, the higher concentration of the Pg-AgNPs exhibited a better safety profile compared to the lower concentration, as indicated by the irritation score.","PeriodicalId":507601,"journal":{"name":"Inorganics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141266001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-03DOI: 10.3390/inorganics12060159
Dawit Tesfaye, Jonas Braun, Mamo Gebrezgiabher, J. Kuchár, J. Černák, Taju Sani, A. Gismelseed, Tim Hochdörffer, Volker Schünemann, C. Anson, Annie K. Powell, Madhu Thomas
A new iron(III) complex (Et3NH)2[Fe(L)2](ClO4)·MeOH (1) where H2L = 2-{(E)-[2-hydroxyphenyl)imino]methyl}phenol has been synthesised and characterised by single crystal XRD, elemental analysis and DC magnetic susceptibility measurements. The dianionic ligands L2− coordinate in a tridentate fashion with the Fe(III) through their deprotonated phenolic oxygens and azomethine nitrogen atoms, resulting in a trans-FeO4N2 chromophore. Variable-temperature magnetic measurements were performed between 300 and 5 K under an applied field of 0.1 T and show that 1 is in the high spin state (S = 5/2) over the whole measured temperature range. This is confirmed by Mössbauer spectroscopy at 77 and 300 K.
我们合成了一种新的铁（III）配合物 (Et3NH)2[Fe(L)2](ClO4)-MeOH (1)，其中 H2L = 2-{(E)-[2-羟基苯基)亚氨基]甲基}苯酚，并通过单晶 XRD、元素分析和直流磁感应强度测量对其进行了表征。二阴离子配体 L2- 通过其去质子化的酚氧原子和偶氮甲基氮原子与铁（III）以三叉配位方式配位，形成反式-FeO4N2 发色团。在 0.1 T 的外加磁场下，在 300 至 5 K 之间进行了变温磁性测量，结果表明 1 在整个测量温度范围内都处于高自旋状态（S = 5/2）。在 77 和 300 K 温度下进行的莫斯鲍尔光谱分析也证实了这一点。
{"title":"Mononuclear Fe(III) Schiff Base Complex with Trans-FeO4N2 Chromophore of o-Aminophenol Origin: Synthesis, Characterisation, Crystal Structure, and Spin State Investigation","authors":"Dawit Tesfaye, Jonas Braun, Mamo Gebrezgiabher, J. Kuchár, J. Černák, Taju Sani, A. Gismelseed, Tim Hochdörffer, Volker Schünemann, C. Anson, Annie K. Powell, Madhu Thomas","doi":"10.3390/inorganics12060159","DOIUrl":"https://doi.org/10.3390/inorganics12060159","url":null,"abstract":"A new iron(III) complex (Et3NH)2[Fe(L)2](ClO4)·MeOH (1) where H2L = 2-{(E)-[2-hydroxyphenyl)imino]methyl}phenol has been synthesised and characterised by single crystal XRD, elemental analysis and DC magnetic susceptibility measurements. The dianionic ligands L2− coordinate in a tridentate fashion with the Fe(III) through their deprotonated phenolic oxygens and azomethine nitrogen atoms, resulting in a trans-FeO4N2 chromophore. Variable-temperature magnetic measurements were performed between 300 and 5 K under an applied field of 0.1 T and show that 1 is in the high spin state (S = 5/2) over the whole measured temperature range. This is confirmed by Mössbauer spectroscopy at 77 and 300 K.","PeriodicalId":507601,"journal":{"name":"Inorganics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141269616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.3390/inorganics12060158
Tamara Tŏpala, Ionel Fizeșan, Andreea-Elena Petru, A. Castiñeiras, A. Bodoki, L. Oprean, Marcos Escolano, Gloria Alzuet-Piña
Four complexes of essential metal ions, Cu(II) and Ni(II), with the new sulfonamide ligand N-(pyridin-2-ylmethyl)quinoline-8-sulfonamide (HQSMP) were synthesized and physicochemically and structurally characterized. Complex [Cu(QSMP)Cl]n (2) consists of a polymeric chain formed by distorted square pyramidal units. In 2, the sulfonamide ligand acts as a bridge coordinating to one Cu(II) through its three N atoms and to another metal ion via one O atom in the sulfonamido group, while the pentacoordinate complex [Cu(QSMP)(C6H5COO)] (3) presents a highly distorted square pyramidal geometry. Complex [Ni(QSMP)(C6H5COO)(CH3OH)][Ni(QSMP)(CH3COO)(CH3OH)] (4) consists of two mononuclear entities containing different anion coligands, either a benzoate or an acetate group. Both units exhibit a distorted octahedral geometry. The interaction of the complexes with CT-DNA was studied by means of UV-Vis and fluorescence spectroscopy, interestingly revealing that the Ni(II) complex presents the highest affinity towards the nucleic acid. Complexes 1 and 2 are able to cleave DNA. Both compounds show promising nuclease activity at relatively low concentrations by mediating the production of a reactive oxygen species (ROS). The interaction of the four complexes with bovine serum albumin (BSA) was also investigated, showing that the compounds can bind to serum proteins. The antitumor potential of complexes 1 and 2 was evaluated against the A549 lung adenocarcinoma cell line, revealing cytotoxic properties that were both dose- and time-dependent.
{"title":"Evaluation of DNA and BSA-Binding, Nuclease Activity, and Anticancer Properties of New Cu(II) and Ni(II) Complexes with Quinoline-Derived Sulfonamides","authors":"Tamara Tŏpala, Ionel Fizeșan, Andreea-Elena Petru, A. Castiñeiras, A. Bodoki, L. Oprean, Marcos Escolano, Gloria Alzuet-Piña","doi":"10.3390/inorganics12060158","DOIUrl":"https://doi.org/10.3390/inorganics12060158","url":null,"abstract":"Four complexes of essential metal ions, Cu(II) and Ni(II), with the new sulfonamide ligand N-(pyridin-2-ylmethyl)quinoline-8-sulfonamide (HQSMP) were synthesized and physicochemically and structurally characterized. Complex [Cu(QSMP)Cl]n (2) consists of a polymeric chain formed by distorted square pyramidal units. In 2, the sulfonamide ligand acts as a bridge coordinating to one Cu(II) through its three N atoms and to another metal ion via one O atom in the sulfonamido group, while the pentacoordinate complex [Cu(QSMP)(C6H5COO)] (3) presents a highly distorted square pyramidal geometry. Complex [Ni(QSMP)(C6H5COO)(CH3OH)][Ni(QSMP)(CH3COO)(CH3OH)] (4) consists of two mononuclear entities containing different anion coligands, either a benzoate or an acetate group. Both units exhibit a distorted octahedral geometry. The interaction of the complexes with CT-DNA was studied by means of UV-Vis and fluorescence spectroscopy, interestingly revealing that the Ni(II) complex presents the highest affinity towards the nucleic acid. Complexes 1 and 2 are able to cleave DNA. Both compounds show promising nuclease activity at relatively low concentrations by mediating the production of a reactive oxygen species (ROS). The interaction of the four complexes with bovine serum albumin (BSA) was also investigated, showing that the compounds can bind to serum proteins. The antitumor potential of complexes 1 and 2 was evaluated against the A549 lung adenocarcinoma cell line, revealing cytotoxic properties that were both dose- and time-dependent.","PeriodicalId":507601,"journal":{"name":"Inorganics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141278740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-14DOI: 10.3390/inorganics12050140
Katharina Hankel née Reinhold, Fabian Burzlaff, B. Beele, Fabian Mohr
A family of silver(I) and copper(I) complexes containing carboxylate ligands were prepared from the corresponding carboxylic acids and Ag2O. The compounds were characterized by various spectroscopic methods and X-ray diffraction. In the solid state, the silver(I) salts are coordination polymers based on dinuclear silver species with bridging carboxylate ligands. The reaction of these silver salts with Ph3P gives four-coordinate, tetrahedral bis(phosphine) complexes. Analogous copper(I) bis(phosphine) compounds were prepared by the reduction of copper(II) carboxylates with Ph3P. Decomposition temperatures and thermal decomposition products were studied by TGA/DSC measurements. The metal compounds decomposed cleanly to their respective metals (silver or copper) at temperatures ranging from 206 to 338 °C.
利用相应的羧酸和 Ag2O 制备了一系列含有羧酸配体的银（I）和铜（I）配合物。这些化合物通过各种光谱方法和 X 射线衍射法进行了表征。在固态下，银（I）盐是基于二核银物种与桥接羧酸配体的配位聚合物。这些银盐与 Ph3P 反应生成四配位的四面体双（膦）络合物。通过羧酸铜（II）与 Ph3P 的还原反应，制备出了类似的双（膦）铜（I）化合物。通过 TGA/DSC 测量研究了分解温度和热分解产物。金属化合物在 206 至 338 °C 的温度范围内分解为各自的金属（银或铜）。
{"title":"Silver(I) and Copper(I) Complexes of Dicarboxylic Acid Derivatives: Synthesis, Characterization and Thermal Studies","authors":"Katharina Hankel née Reinhold, Fabian Burzlaff, B. Beele, Fabian Mohr","doi":"10.3390/inorganics12050140","DOIUrl":"https://doi.org/10.3390/inorganics12050140","url":null,"abstract":"A family of silver(I) and copper(I) complexes containing carboxylate ligands were prepared from the corresponding carboxylic acids and Ag2O. The compounds were characterized by various spectroscopic methods and X-ray diffraction. In the solid state, the silver(I) salts are coordination polymers based on dinuclear silver species with bridging carboxylate ligands. The reaction of these silver salts with Ph3P gives four-coordinate, tetrahedral bis(phosphine) complexes. Analogous copper(I) bis(phosphine) compounds were prepared by the reduction of copper(II) carboxylates with Ph3P. Decomposition temperatures and thermal decomposition products were studied by TGA/DSC measurements. The metal compounds decomposed cleanly to their respective metals (silver or copper) at temperatures ranging from 206 to 338 °C.","PeriodicalId":507601,"journal":{"name":"Inorganics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-13DOI: 10.3390/inorganics12050139
Mridul Boro, Subham Banik, R. Gomila, Antonio Frontera, M. Barceló-Oliver, M. Bhattacharyya
Two new Mn(II) and Zn(II) metal–organic compounds of 1,10-phenanthroline and methyl benzoates viz. [Mn(phen)2Cl2]2-ClBzH (1) and [Zn(4-MeBz)2(2-AmPy)2] (2) (where 4-MeBz = 4-methylbenzoate, 2-AmPy = 2-aminopyridine, phen = 1,10-phenanthroline, 2-ClBzH = 2-chlorobenzoic acid) were synthesized and characterized using elemental analysis, TGA, spectroscopic (FTIR, electronic) and single crystal X-ray diffraction techniques. The crystal structure analysis of the compounds revealed the presence of various non-covalent interactions, which provides stability to the crystal structures. The crystal structure analysis of compound 1 revealed the formation of a supramolecular dimer of 2-ClBzH enclathrate within the hexameric host cavity formed by the neighboring monomeric units. Compound 2 is a mononuclear compound of Zn(II) where flexible binding topologies of 4-CH3Bz are observed with the metal center. Moreover, various non-covalent interactions, such as lp(O)-π, lp(Cl)-π, C–H∙∙∙Cl, π-stacking interactions as well as N–H∙∙∙O, C–H∙∙∙O and C–H∙∙∙π hydrogen bonding interactions, are found to be involved in plateauing the molecular self-association of the compounds. The remarkable enclathration of the H-bonded 2-ClBzH dimer into a supramolecular cavity formed by two [Mn(phen)2Cl2] complexes were further studied theoretically using density functional theory (DFT) calculations, the non-covalent interaction (NCI) plot index and quantum theory of atoms in molecules (QTAIM) computational tools. Synergistic effects were also analyzed using molecular electrostatic potential (MEP) surface analysis.
{"title":"Supramolecular Assemblies in Mn (II) and Zn (II) Metal–Organic Compounds Involving Phenanthroline and Benzoate: Experimental and Theoretical Studies","authors":"Mridul Boro, Subham Banik, R. Gomila, Antonio Frontera, M. Barceló-Oliver, M. Bhattacharyya","doi":"10.3390/inorganics12050139","DOIUrl":"https://doi.org/10.3390/inorganics12050139","url":null,"abstract":"Two new Mn(II) and Zn(II) metal–organic compounds of 1,10-phenanthroline and methyl benzoates viz. [Mn(phen)2Cl2]2-ClBzH (1) and [Zn(4-MeBz)2(2-AmPy)2] (2) (where 4-MeBz = 4-methylbenzoate, 2-AmPy = 2-aminopyridine, phen = 1,10-phenanthroline, 2-ClBzH = 2-chlorobenzoic acid) were synthesized and characterized using elemental analysis, TGA, spectroscopic (FTIR, electronic) and single crystal X-ray diffraction techniques. The crystal structure analysis of the compounds revealed the presence of various non-covalent interactions, which provides stability to the crystal structures. The crystal structure analysis of compound 1 revealed the formation of a supramolecular dimer of 2-ClBzH enclathrate within the hexameric host cavity formed by the neighboring monomeric units. Compound 2 is a mononuclear compound of Zn(II) where flexible binding topologies of 4-CH3Bz are observed with the metal center. Moreover, various non-covalent interactions, such as lp(O)-π, lp(Cl)-π, C–H∙∙∙Cl, π-stacking interactions as well as N–H∙∙∙O, C–H∙∙∙O and C–H∙∙∙π hydrogen bonding interactions, are found to be involved in plateauing the molecular self-association of the compounds. The remarkable enclathration of the H-bonded 2-ClBzH dimer into a supramolecular cavity formed by two [Mn(phen)2Cl2] complexes were further studied theoretically using density functional theory (DFT) calculations, the non-covalent interaction (NCI) plot index and quantum theory of atoms in molecules (QTAIM) computational tools. Synergistic effects were also analyzed using molecular electrostatic potential (MEP) surface analysis.","PeriodicalId":507601,"journal":{"name":"Inorganics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140984737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-10DOI: 10.3390/inorganics12050137
K. Mažeika, V. Melvydas, Dovilė Čepukoit
Iron compounds can be used in antimicrobial applications by exploiting the toxicity of divalent iron to living organisms due to the Fenton reaction. In this study, the growth inhibitory effects of ferrous sulfate FeSO4·7H2O and ferric chloride FeCl3·6H2O were observed on Metschnikowia clade and Saccharomyces cerevisiae yeast cells. The relatively high amount of reduced Fe3+ to Fe2+ in the growth medium determined by Mössbauer spectroscopy may contribute to the antimicrobial activity of ferric chloride. In order to test the reducing ability of sugars in the growth media of yeasts, the reaction of ferric chloride FeCl3·6H2O with sugars was investigated. In mixtures of FeCl3·6H2O and fructose, approximately two thirds of Fe3+ can be reduced to Fe2+. When the mixture of FeCl3·6H2O and fructose is placed on the surface of aluminum foil, an iron film is formed on the surface of the aluminum due to the reduction by both fructose and aluminum. The relative amount of Fe3+ which was reduced to Fe0 reached 68%.
{"title":"Reduction of Ferric Chloride in Yeast Growth Media, by Sugars and Aluminum","authors":"K. Mažeika, V. Melvydas, Dovilė Čepukoit","doi":"10.3390/inorganics12050137","DOIUrl":"https://doi.org/10.3390/inorganics12050137","url":null,"abstract":"Iron compounds can be used in antimicrobial applications by exploiting the toxicity of divalent iron to living organisms due to the Fenton reaction. In this study, the growth inhibitory effects of ferrous sulfate FeSO4·7H2O and ferric chloride FeCl3·6H2O were observed on Metschnikowia clade and Saccharomyces cerevisiae yeast cells. The relatively high amount of reduced Fe3+ to Fe2+ in the growth medium determined by Mössbauer spectroscopy may contribute to the antimicrobial activity of ferric chloride. In order to test the reducing ability of sugars in the growth media of yeasts, the reaction of ferric chloride FeCl3·6H2O with sugars was investigated. In mixtures of FeCl3·6H2O and fructose, approximately two thirds of Fe3+ can be reduced to Fe2+. When the mixture of FeCl3·6H2O and fructose is placed on the surface of aluminum foil, an iron film is formed on the surface of the aluminum due to the reduction by both fructose and aluminum. The relative amount of Fe3+ which was reduced to Fe0 reached 68%.","PeriodicalId":507601,"journal":{"name":"Inorganics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140993819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-10DOI: 10.3390/inorganics12050138
Georgios I. Psarras, Ariadni Zianna, A. Hatzidimitriou, G. Psomas
Three neutral nickel(II) complexes of 3,5–dibromo–salicylaldehyde (3,5–diBr–saloH) were synthesized in the presence or absence of 1,10–phenanthroline (phen) or its derivative 2,9–dimethyl–1,10–phenanthroline (neoc) as co–ligands, namely [Ni(3,5–diBr–salo)2(neoc)] (complex 1), [Ni(3,5–diBr–salo)2(phen)] (complex 2) and [Ni(3,5–diBr–salo)2(H2O)2] (complex 3), and were characterized by various techniques. The crystal structure of [Ni(3,5–diBr–salo)2(neoc)] was determined by single-crystal X-ray crystallography. According to employed studying techniques, the complexes interact tightly with calf-thymus DNA by an intercalative fashion. Furthermore, compounds 1–3 bind tightly and reversibly to human and bovine serum albumin.
在 1,10-菲罗啉（phen）或其衍生物 2,9-二甲基-1-菲罗啉（neoc）作为共配位体存在或不存在的情况下，合成了 3,5-二溴水杨醛（3,5-diBr-saloH）的三种中性镍（II）配合物、10-菲罗啉（neoc）作为共配位体的情况下合成了[Ni(3,5-diBr-salo)2(neoc)]（络合物 1）、[Ni(3,5-diBr-salo)2(phen)]（络合物 2）和[Ni(3,5-diBr-salo)2(H2O)2]（络合物 3），并通过各种技术对它们进行了表征。单晶 X 射线晶体学确定了[Ni(3,5-diBr-salo)2(neoc)]的晶体结构。根据所采用的研究技术，这些复合物以插层方式与小牛胸腺 DNA 紧密结合。此外，化合物 1-3 还能与人和牛血清白蛋白紧密且可逆地结合。
{"title":"Coordination Compounds of Nickel(II) with 3,5–Dibromo–Salicylaldehyde: Structure and Interaction with Biomolecules","authors":"Georgios I. Psarras, Ariadni Zianna, A. Hatzidimitriou, G. Psomas","doi":"10.3390/inorganics12050138","DOIUrl":"https://doi.org/10.3390/inorganics12050138","url":null,"abstract":"Three neutral nickel(II) complexes of 3,5–dibromo–salicylaldehyde (3,5–diBr–saloH) were synthesized in the presence or absence of 1,10–phenanthroline (phen) or its derivative 2,9–dimethyl–1,10–phenanthroline (neoc) as co–ligands, namely [Ni(3,5–diBr–salo)2(neoc)] (complex 1), [Ni(3,5–diBr–salo)2(phen)] (complex 2) and [Ni(3,5–diBr–salo)2(H2O)2] (complex 3), and were characterized by various techniques. The crystal structure of [Ni(3,5–diBr–salo)2(neoc)] was determined by single-crystal X-ray crystallography. According to employed studying techniques, the complexes interact tightly with calf-thymus DNA by an intercalative fashion. Furthermore, compounds 1–3 bind tightly and reversibly to human and bovine serum albumin.","PeriodicalId":507601,"journal":{"name":"Inorganics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140991210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-05DOI: 10.3390/inorganics12050136
Yanshuai Cui, Shukai Li, Ning Yu, Xiaodong Yu, Xianbing Ji, Longgang Wang
4-nitrophenol (4-NP) is a frequently encountered toxic phenolic organic pollutant in water. It is important to develop a simple method to treat 4-NP. Small and monodispersed gold nanoparticles often have good catalytic performance of 4-NP. Hemoglobin (Hb) is a kind of common and important protein in organisms. Herein, highly biocompatible bovine hemoglobin-stabilized gold nanoparticles (Aun-Hb NPs) were synthesized using hemoglobin as a biological template. Then, the size, zeta potential, and composition of Aun-Hb NPs were investigated by transmission electron microscopy, dynamic light scattering, and X-ray photoelectron spectroscopy. The Aun-Hb NPs with small gold nanoparticles of about 1.4–2.4 nm had good catalytic capabilities in reducing 4-NP to form 4-aminophenol. Au20-Hb NPs demonstrated superior catalytic efficiency in the reduction of 4-NP when compared to other nanoparticles. Moreover, as-synthesized Au20-Hb NPs exhibited excellent biocompatibility through the MTT experiment. The method of preparation of gold nanoparticles offers one way to prepare metal nanoparticles for good potential catalytic applications of gold nanoparticles.
{"title":"Highly Biocompatible Hemoglobin-Stabilized Gold Nanoparticles for an Enhanced Catalytic Reduction of 4-Nitrophenol","authors":"Yanshuai Cui, Shukai Li, Ning Yu, Xiaodong Yu, Xianbing Ji, Longgang Wang","doi":"10.3390/inorganics12050136","DOIUrl":"https://doi.org/10.3390/inorganics12050136","url":null,"abstract":"4-nitrophenol (4-NP) is a frequently encountered toxic phenolic organic pollutant in water. It is important to develop a simple method to treat 4-NP. Small and monodispersed gold nanoparticles often have good catalytic performance of 4-NP. Hemoglobin (Hb) is a kind of common and important protein in organisms. Herein, highly biocompatible bovine hemoglobin-stabilized gold nanoparticles (Aun-Hb NPs) were synthesized using hemoglobin as a biological template. Then, the size, zeta potential, and composition of Aun-Hb NPs were investigated by transmission electron microscopy, dynamic light scattering, and X-ray photoelectron spectroscopy. The Aun-Hb NPs with small gold nanoparticles of about 1.4–2.4 nm had good catalytic capabilities in reducing 4-NP to form 4-aminophenol. Au20-Hb NPs demonstrated superior catalytic efficiency in the reduction of 4-NP when compared to other nanoparticles. Moreover, as-synthesized Au20-Hb NPs exhibited excellent biocompatibility through the MTT experiment. The method of preparation of gold nanoparticles offers one way to prepare metal nanoparticles for good potential catalytic applications of gold nanoparticles.","PeriodicalId":507601,"journal":{"name":"Inorganics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141011400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-04DOI: 10.3390/inorganics12050135
Beatriz P. Machado, Maria Celador-Garcia, Vitor Rosa, Clara S. B. Gomes
Dimeric bismuth(III) complexes bearing bis(aryl-imino)acenaphthene (Aryl-BIAN) donor ligands of the general formulae [(Dipp-BIAN)BiCl3]2 2, [(o-iPr-BIAN)BiCl3]2 3, and [(p-iPr-BIAN)BiCl3]2 4, where Dipp = diisopropyl, o-iPr = ortho-isopropyl and p-iPr = para-isopropyl, were prepared by reaction of the corresponding neutral BIAN ligand with BiCl3, under inert atmosphere conditions. X-ray studies were performed, and their molecular structures were determined. The individual contributions of intermolecular interactions to crystal packing have been quantified by means of Hirsfeld surface analysis.
{"title":"Elucidating the Structural Features of Bis(arylimino)acenaphthene (Aryl-BIAN) Bismuth Complexes: A Combined Single-Crystal X-ray Diffraction and Hirshfeld Analysis Approach","authors":"Beatriz P. Machado, Maria Celador-Garcia, Vitor Rosa, Clara S. B. Gomes","doi":"10.3390/inorganics12050135","DOIUrl":"https://doi.org/10.3390/inorganics12050135","url":null,"abstract":"Dimeric bismuth(III) complexes bearing bis(aryl-imino)acenaphthene (Aryl-BIAN) donor ligands of the general formulae [(Dipp-BIAN)BiCl3]2 2, [(o-iPr-BIAN)BiCl3]2 3, and [(p-iPr-BIAN)BiCl3]2 4, where Dipp = diisopropyl, o-iPr = ortho-isopropyl and p-iPr = para-isopropyl, were prepared by reaction of the corresponding neutral BIAN ligand with BiCl3, under inert atmosphere conditions. X-ray studies were performed, and their molecular structures were determined. The individual contributions of intermolecular interactions to crystal packing have been quantified by means of Hirsfeld surface analysis.","PeriodicalId":507601,"journal":{"name":"Inorganics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-03DOI: 10.3390/inorganics12050133
Javiera Órdenes-Rojas, Paola Risco, José Ortega-Campos, Germán Barriga-González, Ana Liempi, U. Kemmerling, D. Gambino, L. Otero, Claudio Olea Azar, Esteban Rodríguez-Arce
In the search for a more effective chemotherapy for the treatment of Chagas’ disease, caused by Trypanosoma cruzi parasite, the use of gold compounds may be a promising approach. In this work, four gold(I) compounds [AuCl(HL)], (HL = bioactive 5-nitrofuryl containing thiosemicarbazones) were studied. The compounds were theoretically characterized, showing identical chemical structures with the metal ion located in a linear coordination environment and the thiosemicarbazones acting as monodentate ligands. Cyclic voltammetry and Electron Spin Resonance (ESR) studies demonstrated that the complexes could generate the nitro anion radical (NO2−) by reduction of the nitro moiety. The compounds were evaluated in vitro on the trypomastigote form of T. cruzi and human cells of endothelial morphology. The gold compounds studied showed activity in the micromolar range against T. cruzi. The most active compounds (IC50 of around 10 μM) showed an enhancement of the antiparasitic activity compared with their respective bioactive ligands and moderate selectivity. To get insight into the anti-chagasic mechanism of action, the intracellular free radical production capacity of the gold compounds was assessed by ESR and fluorescence measurements. DMPO (5,5-dimethyl-1-pirroline-N-oxide) spin adducts related to the bioreduction of the complexes and redox cycling processes were characterized. The potential oxidative stress mechanism against T. cruzi was confirmed.
为了寻找一种更有效的化疗方法来治疗由克鲁斯锥虫寄生虫引起的南美锥虫病，使用金化合物可能是一种很有前景的方法。在这项工作中，研究了四种金（I）化合物 [AuCl(HL)]（HL = 含有生物活性的 5-硝基呋喃硫代氨基脲）。这些化合物具有相同的化学结构，金属离子位于线性配位环境中，而硫代氨基脲则作为单齿配体。循环伏安法和电子自旋共振（ESR）研究表明，这些复合物可以通过还原硝基分子产生硝基阴离子自由基（NO2-）。在体外对这些化合物进行了评估，结果表明它们能抑制恙虫的胰母细胞形态和人的内皮形态细胞。所研究的金化合物对 T. cruzi 的活性在微摩尔范围内。与各自的生物活性配体相比，活性最强的化合物（IC50 约为 10 μM）显示出更强的抗寄生虫活性和适度的选择性。为了深入了解金化合物的抗寄生虫作用机制，我们通过 ESR 和荧光测量评估了金化合物在细胞内产生自由基的能力。对与复合物生物还原和氧化还原循环过程有关的 DMPO（5,5-二甲基-1-吡咯啉-N-氧化物）自旋加合物进行了表征。证实了对 T. cruzi 的潜在氧化应激机制。
{"title":"Mechanism of Anti-Trypanosoma cruzi Action of Gold(I) Compounds: A Theoretical and Experimental Approach","authors":"Javiera Órdenes-Rojas, Paola Risco, José Ortega-Campos, Germán Barriga-González, Ana Liempi, U. Kemmerling, D. Gambino, L. Otero, Claudio Olea Azar, Esteban Rodríguez-Arce","doi":"10.3390/inorganics12050133","DOIUrl":"https://doi.org/10.3390/inorganics12050133","url":null,"abstract":"In the search for a more effective chemotherapy for the treatment of Chagas’ disease, caused by Trypanosoma cruzi parasite, the use of gold compounds may be a promising approach. In this work, four gold(I) compounds [AuCl(HL)], (HL = bioactive 5-nitrofuryl containing thiosemicarbazones) were studied. The compounds were theoretically characterized, showing identical chemical structures with the metal ion located in a linear coordination environment and the thiosemicarbazones acting as monodentate ligands. Cyclic voltammetry and Electron Spin Resonance (ESR) studies demonstrated that the complexes could generate the nitro anion radical (NO2−) by reduction of the nitro moiety. The compounds were evaluated in vitro on the trypomastigote form of T. cruzi and human cells of endothelial morphology. The gold compounds studied showed activity in the micromolar range against T. cruzi. The most active compounds (IC50 of around 10 μM) showed an enhancement of the antiparasitic activity compared with their respective bioactive ligands and moderate selectivity. To get insight into the anti-chagasic mechanism of action, the intracellular free radical production capacity of the gold compounds was assessed by ESR and fluorescence measurements. DMPO (5,5-dimethyl-1-pirroline-N-oxide) spin adducts related to the bioreduction of the complexes and redox cycling processes were characterized. The potential oxidative stress mechanism against T. cruzi was confirmed.","PeriodicalId":507601,"journal":{"name":"Inorganics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141016292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：