{"title":"Selenium nanoparticles enhance the chemotherapeutic efficacy of pemetrexed against non-small cell lung cancer","authors":"","doi":"10.1016/j.cclet.2024.110018","DOIUrl":null,"url":null,"abstract":"<div><p>Selenium (Se) plays an important role in the development and treatment of lung cancer, yet its specific mechanisms remain elusive. Lower Se level in serum was noted in lung cancer patients compared to normal controls. Therefore, developing effective therapeutic adjuvants containing Se might benefit the treatment of lung cancer patients. This study aimed to investigate the association between Se and the chemotherapeutic efficacy of lung cancer. Lentinan-modified selenium nanoparticles (LET-SeNPs) were created to develop and verify the effectiveness of Se containing adjuvant applied with pemetrexed on lung cancer cells. A synergistic effect was observed between LET-SeNPs and pemetrexed <em>in vitro</em>. The combination of LET-SeNPs and pemetrexed could induce reactive oxygen species overproduction, mitochondrial dysfunction and DNA damage, ultimately leading to cancer cell apoptosis. It is implied that LET-SeNPs might be a promising sensitizer to pemetrexed chemotherapy and could potentially enhance chemotherapy efficiency in non-small cell lung cancer.</p></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":null,"pages":null},"PeriodicalIF":9.4000,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Chemical Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1001841724005370","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Selenium (Se) plays an important role in the development and treatment of lung cancer, yet its specific mechanisms remain elusive. Lower Se level in serum was noted in lung cancer patients compared to normal controls. Therefore, developing effective therapeutic adjuvants containing Se might benefit the treatment of lung cancer patients. This study aimed to investigate the association between Se and the chemotherapeutic efficacy of lung cancer. Lentinan-modified selenium nanoparticles (LET-SeNPs) were created to develop and verify the effectiveness of Se containing adjuvant applied with pemetrexed on lung cancer cells. A synergistic effect was observed between LET-SeNPs and pemetrexed in vitro. The combination of LET-SeNPs and pemetrexed could induce reactive oxygen species overproduction, mitochondrial dysfunction and DNA damage, ultimately leading to cancer cell apoptosis. It is implied that LET-SeNPs might be a promising sensitizer to pemetrexed chemotherapy and could potentially enhance chemotherapy efficiency in non-small cell lung cancer.
硒(Se)在肺癌的发展和治疗中发挥着重要作用,但其具体机制仍难以捉摸。与正常对照组相比,肺癌患者血清中的硒含量较低。因此,开发有效的含 Se 辅助治疗剂可能对肺癌患者的治疗有益。本研究旨在探讨 Se 与肺癌化疗疗效之间的关系。研究人员制作了龙胆素修饰的硒纳米粒子(LET-SeNPs),以开发和验证含Se的辅助剂与培美曲塞一起应用对肺癌细胞的疗效。在体外实验中,LET-SeNPs 与培美曲塞之间产生了协同效应。LET-SeNPs 与培美曲塞的结合可诱导活性氧过量产生、线粒体功能障碍和 DNA 损伤,最终导致癌细胞凋亡。这意味着 LET-SeNPs 可能是培美曲塞化疗的增敏剂,并有可能提高非小细胞肺癌的化疗效率。
期刊介绍:
Chinese Chemical Letters (CCL) (ISSN 1001-8417) was founded in July 1990. The journal publishes preliminary accounts in the whole field of chemistry, including inorganic chemistry, organic chemistry, analytical chemistry, physical chemistry, polymer chemistry, applied chemistry, etc.Chinese Chemical Letters does not accept articles previously published or scheduled to be published. To verify originality, your article may be checked by the originality detection service CrossCheck.