A systematic review of quantitative EEG findings in Fibromyalgia, Chronic Fatigue Syndrome and Long COVID

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2024-05-06 DOI:10.1016/j.clinph.2024.04.019

Bárbara Silva-Passadouro , Arnas Tamasauskas , Omar Khoja , Alexander J. Casson , Ioannis Delis , Christopher Brown , Manoj Sivan

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Abstract

Fibromyalgia Syndrome (FMS), Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID (LC) are similar multisymptom clinical syndromes but with difference in dominant symptoms in each individual. There is existing and emerging literature on possible functional alterations of the central nervous system in these conditions. This review aims to synthesise and appraise the literature on resting-state quantitative EEG (qEEG) in FMS, ME/CFS and LC, drawing on previous research on FMS and ME/CFS to help understand neuropathophysiology of the new condition LC.

A systematic search of MEDLINE, Embase, CINHAL, PsycINFO and Web of Science databases for articles published between December 1994 and September 2023 was performed.

Out of the initial 2510 studies identified, 17 articles were retrieved that met all the predetermined selection criteria, particularly of assessing qEEG changes in one of the three conditions compared to healthy controls. All studies scored moderate to high quality on the Newcastle-Ottawa scale. There was a general trend for decreased low-frequency EEG band activity (delta, theta, and alpha) and increased high-frequency EEG beta activity in FMS, differing to that found in ME/CFS. The limited LC studies included in this review focused mainly on cognitive impairments and showed mixed findings not consistent with patterns observed in FMS and ME/CFS.

Our findings suggest different patterns of qEEG brainwave activity in FMS and ME/CFS. Further research is required to explore whether there are phenotypes within LC that have EEG signatures similar to FMS or ME/CFS.

This could inform identification of reliable diagnostic markers and possible targets for neuromodulation therapies tailored to each clinical syndrome.

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对纤维肌痛、慢性疲劳综合征和长 COVID 的定量脑电图结果进行系统回顾

纤维肌痛综合征（FMS）、肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）和长COVID（LC）是类似的多症状临床综合征，但每个人的主要症状不同。关于这些病症的中枢神经系统可能发生的功能性改变，现有文献和新兴文献均有论述。本综述旨在综合和评估有关 FMS、ME/CFS 和 LC 的静息态定量脑电图（qEEG）的文献，借鉴以往对 FMS 和 ME/CFS 的研究，帮助理解 LC 这一新病症的神经病理生理学。我们在 MEDLINE、Embase、CINHAL、PsycINFO 和 Web of Science 数据库中对 1994 年 12 月至 2023 年 9 月间发表的文章进行了系统检索。在最初确定的 2510 篇研究中，检索到 17 篇符合所有预定选择标准的文章，尤其是评估三种情况之一与健康对照组相比的 qEEG 变化的文章。根据纽卡斯尔-渥太华量表，所有研究的质量均为中上等。FMS患者的低频脑电图波段活动（δ、θ和α）普遍减少，高频脑电图β活动增加，这与ME/CFS患者的情况不同。本综述所包含的有限的LC研究主要集中于认知障碍，研究结果参差不齐，与在FMS和ME/CFS中观察到的模式并不一致。我们的研究结果表明，FMS 和 ME/CFS 的 qEEG 脑电波活动模式不同，需要进一步研究，以探索 LC 中是否存在与 FMS 或 ME/CFS 相似的脑电波特征表型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.