Transient kinetics reveal the mechanism of competitive inhibition of the neutral amino acid transporter ASCT2

IF 4.8 2区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Journal of Biological Chemistry Pub Date : 2024-05-01 DOI:10.1016/j.jbc.2024.107382
Yang Dong, Jiali Wang, Christof Grewer
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瞬时动力学揭示了中性氨基酸转运体 ASCT2 的竞争性抑制机制
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来源期刊
Journal of Biological Chemistry
Journal of Biological Chemistry 生物-生化与分子生物学
CiteScore
8.50
自引率
4.20%
发文量
1233
审稿时长
63 days
期刊介绍: The Journal of Biological Chemistry welcomes high-quality science that seeks to elucidate the molecular and cellular basis of biological processes. Papers published in JBC can therefore fall under the umbrellas of not only biological chemistry, chemical biology, or biochemistry, but also allied disciplines such as biophysics, systems biology, RNA biology, immunology, microbiology, neurobiology, epigenetics, computational biology, ’omics, and many more. The outcome of our focus on papers that contribute novel and important mechanistic insights, rather than on a particular topic area, is that JBC is truly a melting pot for scientists across disciplines. In addition, JBC welcomes papers that describe methods that will help scientists push their biochemical inquiries forward and resources that will be of use to the research community.
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