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IF 4.8 2区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-07-01 DOI: 10.1016/s0021-9258(24)02086-6
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引用次数: 0
Ferroptosis regulation by Cap’n’collar family transcription factors Cap'n'collar家族转录因子对铁蛋白沉积的调控
IF 4.8 2区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-07-01 DOI: 10.1016/j.jbc.2024.107583
Magdalena B. Murray, Scott J. Dixon
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引用次数: 0
Classical and non-classical effects of angiotensin converting enzyme: how increased ACE enhances myeloid immune function. 血管紧张素转换酶的经典和非经典效应:血管紧张素转换酶的增加如何增强骨髓免疫功能。
IF 4.8 2区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-05-01 DOI: 10.1016/j.jbc.2024.107388
Kenneth E. Bernstein, Duo-Yao Cao, Tomohiro Shibata, Suguru Saito, E. Bernstein, Erika Nishi, Michifumi Yamashita, Warren G. Tourtellotte, Tuantuan V. Zhao, Zakir Khan
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引用次数: 0
Post-translational control of NLRP3 inflammasome signaling NLRP3 炎症小体信号的翻译后控制
IF 4.8 2区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-05-01 DOI: 10.1016/j.jbc.2024.107386
Meghan E. O’Keefe, George Dubyak, Derek W. Abbott
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引用次数: 0
Consensus, controversies, and conundrums of P4-ATPases: the emerging face of eukaryotic lipid flippases P4-ATP 酶的共识、争议和难题:真核生物脂质翻转酶的新面貌
IF 4.8 2区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-05-01 DOI: 10.1016/j.jbc.2024.107387
H. Duan, Huilin Li
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引用次数: 0
Transient kinetics reveal the mechanism of competitive inhibition of the neutral amino acid transporter ASCT2 瞬时动力学揭示了中性氨基酸转运体 ASCT2 的竞争性抑制机制
IF 4.8 2区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-05-01 DOI: 10.1016/j.jbc.2024.107382
Yang Dong, Jiali Wang, Christof Grewer
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引用次数: 0
ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity. ERG激活了具有混合基底腔特征的前列腺上皮细胞的干样增殖-分化程序。
2区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-04-06 DOI: 10.1101/2023.05.15.540839
Weiran Feng, Erik Ladewig, Nazifa Salsabeel, Huiyong Zhao, Young Sun Lee, Anuradha Gopalan, Matthew Lange, Hanzhi Luo, Wenfei Kang, Ning Fan, Eric Rosiek, Elisa de Stanchina, Yu Chen, Brett S Carver, Christina S Leslie, Charles L Sawyers

To gain insight into how ERG translocations cause prostate cancer, we performed single cell transcriptional profiling of an autochthonous mouse model at an early stage of disease initiation. Despite broad expression of ERG in all prostate epithelial cells, proliferation was enriched in a small, stem-like population with mixed-luminal basal identity (called intermediate cells). Through a series of lineage tracing and primary prostate tissue transplantation experiments, we find that tumor initiating activity resides in a subpopulation of basal cells that co-express the luminal genes Tmprss2 and Nkx3.1 (called BasalLum) but not in the larger population of classical Krt8+ luminal cells. Upon ERG activation, BasalLum cells give rise to the highly proliferative intermediate state, which subsequently transitions to the larger population of Krt8+ luminal cells characteristic of ERG-positive human cancers. Furthermore, this proliferative population is characterized by an ERG-specific chromatin state enriched for NFkB, AP-1, STAT and NFAT binding, with implications for TF cooperativity. The fact that the proliferative potential of ERG is enriched in a small stem-like population implicates the chromatin context of these cells as a critical variable for unmasking its oncogenic activity.

为了深入了解ERG易位是如何导致前列腺癌的,我们在疾病的早期阶段对自体小鼠模型进行了单细胞转录谱分析。尽管ERG在所有前列腺上皮细胞中广泛表达,但增殖却集中在具有混合管腔基底特征的小干样群体(称为中间细胞)中。通过一系列系谱追踪和原代前列腺组织移植实验,我们发现肿瘤启动活性存在于共同表达管腔基因Tmprss2和Nkx3.1的基底细胞亚群(称为BasalLum)中,而不存在于较大的经典Krt8+管腔细胞群中。ERG激活后,BasalLum细胞会产生高度增殖的中间状态,随后过渡到ERG阳性人类癌症特有的Krt8+管腔细胞大群体。此外,这种增殖细胞群的特点是富含 NFkB、AP-1、STAT 和 NFAT 结合的 ERG 特异性染色质状态,这对 TF 的合作性有影响。ERG的增殖潜能富集在一个小的干样群体中,这一事实表明这些细胞的染色质环境是揭示其致癌活性的一个关键变量。
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引用次数: 0
A minimum functional form of the E. coli BAM complex constituted by BamADE assembles outer membrane proteins in vitro 由 BamADE 构成的大肠杆菌 BAM 复合物在体外组装外膜蛋白的最小功能形式
IF 4.8 2区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-04-01 DOI: 10.1016/j.jbc.2024.107324
Zhe Wang, Yindi Chu, Qingrong Li, Xiaochen Han, Leyi Zhao, Hanqing Zhang, Kun Cai, Xuyan Zhang, Xingyuan Wang, Youcai Qin, Enguo Fan
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引用次数: 0
Probing RNA Structure and Dynamics using Nanopore and Next Generation Sequencing 利用纳米孔和新一代测序技术探测 RNA 结构和动力学
IF 4.8 2区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-04-01 DOI: 10.1016/j.jbc.2024.107317
Emma Bose, Shengwei Xiong, Alisha N. Jones
{"title":"Probing RNA Structure and Dynamics using Nanopore and Next Generation Sequencing","authors":"Emma Bose, Shengwei Xiong, Alisha N. Jones","doi":"10.1016/j.jbc.2024.107317","DOIUrl":"https://doi.org/10.1016/j.jbc.2024.107317","url":null,"abstract":"","PeriodicalId":51075,"journal":{"name":"Journal of Biological Chemistry","volume":"495 ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140763631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The types and numbers of kinesins and dyneins transporting endocytic cargoes modulate their motility and response to tau 运输内吞货物的驱动蛋白和动力蛋白的类型和数量可调节其运动性和对 tau 的反应
IF 4.8 2区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-04-01 DOI: 10.1016/j.jbc.2024.107323
Daniel Beaudet, Christopher L. Berger, Adam G. Hendricks
{"title":"The types and numbers of kinesins and dyneins transporting endocytic cargoes modulate their motility and response to tau","authors":"Daniel Beaudet, Christopher L. Berger, Adam G. Hendricks","doi":"10.1016/j.jbc.2024.107323","DOIUrl":"https://doi.org/10.1016/j.jbc.2024.107323","url":null,"abstract":"","PeriodicalId":51075,"journal":{"name":"Journal of Biological Chemistry","volume":"29 1","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140770464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Biological Chemistry
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