The Potential for Heart Donation After Death Determination by Circulatory Criteria in the Province of Québec

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS CJC Open Pub Date : 2024-09-01 DOI:10.1016/j.cjco.2024.05.004

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Abstract

Background

Heart donation (HD) by those with death determination by circulatory criteria (DDCC) has been proposed as a method to increase the heart donor pool in response to the growing need for heart transplantation (HT). However, the potential level of HD after DDCC in the province of Québec has not yet been reported. This study aims to assess the suitability for HD among donors with DDCC, and to estimate its impact on HT activity.

Methods

Donation records by those with DDCC in the province of Québec, from January 2016 to December 2020, were retrospectively reviewed for donor and predonation characteristics. Predetermined exclusion criteria were used to evaluate eligibility for HD.

Results

Of the 122 patients with DDCC who were included, 42 (34%) were identified as potentially-eligible heart donors. The median age of potentially-eligible donors was 52 years; 60% were female; and the most prevalent causes leading to organ donation in this group were medical aid in dying (26%), traumatic brain injury (26%), and anoxia (24%). A 19% increase (42 of 225) in potential HT activity was estimated using strict criteria. In only one case did functional warm ischemia time exceed the 30-minute limit.

Conclusions

Using those with DDCC as a new source of heart donors can significantly increase the volume of heart donation in the province of Québec. Implementing an HD program for those with DDCC in Québec may reduce waiting time and increase the number of heart recipients.

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魁北克省按循环标准确定死亡（DCD）后进行心脏捐献的可能性。

背景根据循环标准（DDCC）确定死亡者的心脏捐献（HD）已被提议作为增加心脏捐献者库的一种方法，以应对日益增长的心脏移植（HT）需求。然而，魁北克省在 DDCC 之后的潜在 HD 水平尚未见报道。本研究旨在评估DDCC捐献者是否适合进行HD，并估计其对HT活动的影响。方法回顾性审查了魁北克省2016年1月至2020年12月期间DDCC捐献者的捐献记录，以了解捐献者和捐献前特征。结果在纳入的122名DDCC患者中，有42人（34%）被确定为潜在合格的心脏捐献者。潜在合格捐献者的年龄中位数为52岁；60%为女性；导致该组患者捐献器官的最常见原因是濒死医疗救助（26%）、创伤性脑损伤（26%）和缺氧（24%）。根据严格的标准估计，潜在的热休克活动增加了 19%（225 例中有 42 例）。结论将 DDCC 患者作为新的心脏捐献者来源可显著增加魁北克省的心脏捐献量。在魁北克省为 DDCC 患者实施血液透析计划可缩短等待时间并增加心脏受体的数量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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