Drug carrier wonders: Synthetic strategies of zeolitic imidazolates frameworks (ZIFs) and their applications in drug delivery and anti-cancer activity

IF 15.9 1区化学 Q1 CHEMISTRY, PHYSICAL Advances in Colloid and Interface Science Pub Date : 2024-05-17 DOI:10.1016/j.cis.2024.103184

Hamza Akhtar , Umay Amara , Khalid Mahmood , Muhammad Hanif , Muhammad Khalid , Sobia Qadir , Qiaohong Peng , Muhammad Safdar , Muhammad Amjad , Muhammad Zubair Saif , Aniqa Tahir , Muhammad Yaqub , Kiran Khalid

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Abstract

With the rapid advancement of nanotechnology, stimuli-responsive nanomaterials have emerged as a feasible choice for the designing of controlled drug delivery systems. Zeolitic imidazolates frameworks are a subclass of Metal-organic frameworks (MOFs) that are recognized by their excellent porosity, structural tunability and chemical modifications make them promising materials for loading targeted molecules and therapeutics agents. The biomedical industry uses these porous materials extensively as nano-carriers in drug delivery systems. These MOFs not only possess excellent targeted imaging ability but also cause the death of tumor cells drawing considerable attention in the current framework of anticancer drug delivery systems. In this review, the outline of stability, porosity, mechanism of encapsulation and release of anticancer drug have been reported extensively. In the end, we also discuss a brief outline of current challenges and future perspectives of ZIFs in the biomedical world.

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药物载体奇观：沸石咪唑酸盐框架 (ZIF) 的合成策略及其在药物输送和抗癌活性方面的应用

随着纳米技术的飞速发展，刺激响应型纳米材料已成为设计可控给药系统的可行选择。沸石咪唑酸盐框架是金属有机框架（MOFs）的一个子类，其优异的多孔性、结构可调性和化学修饰性使其成为装载靶向分子和治疗药物的理想材料。生物医学行业将这些多孔材料广泛用作药物输送系统中的纳米载体。这些 MOFs 不仅具有出色的靶向成像能力，还能导致肿瘤细胞死亡，在当前的抗癌药物输送系统框架中备受关注。在这篇综述中，对抗癌药物的稳定性、孔隙率、封装和释放机理进行了广泛的概述。最后，我们还简要概述了 ZIF 在生物医学领域目前面临的挑战和未来展望。

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来源期刊

Advances in Colloid and Interface Science 化学-物理化学

CiteScore

28.50

自引率

2.60%

发文量

175

审稿时长

31 days

期刊介绍： "Advances in Colloid and Interface Science" is an international journal that focuses on experimental and theoretical developments in interfacial and colloidal phenomena. The journal covers a wide range of disciplines including biology, chemistry, physics, and technology. The journal accepts review articles on any topic within the scope of colloid and interface science. These articles should provide an in-depth analysis of the subject matter, offering a critical review of the current state of the field. The author's informed opinion on the topic should also be included. The manuscript should compare and contrast ideas found in the reviewed literature and address the limitations of these ideas. Typically, the articles published in this journal are written by recognized experts in the field.