Impact of SARS-CoV-2 infection on short-term postoperative outcomes after gastroenterological cancer surgery using data from a nationwide database in Japan

IF 2.9 4区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Annals of Gastroenterological Surgery Pub Date : 2024-05-01 DOI:10.1002/ags3.12812
Masashi Takeuchi, Taizo Hibi, Ryo Seishima, Yusuke Takemura, Hiromichi Maeda, Genta Toshima, Noriyuki Ishida, Naoki Miyazaki, Akinobu Taketomi, Yoshihiro Kakeji, Yasuyuki Seto, Hideki Ueno, Masaki Mori, Ken Shirabe, Yuko Kitagawa
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Abstract

Background

Due to the coronavirus disease 2019 (COVID-19) pandemic, cancer screening, diagnosis, and treatment have changed. This study aimed to investigate the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection prior to gastroenterological cancer surgeries on postoperative complications using data from a nationwide database in Japan.

Methods

Data on patients who underwent surgery for cancer including esophageal, gastric, colon, rectal, liver, and pancreatic cancer between July 1, 2019, and September 300, 2022, from real-world sources in Japan were analyzed. The association between preoperative SARS-CoV-2 infection and short-term postoperative outcomes was evaluated. A similar analysis stratified according to the interval from SARS-CoV-2 infection to surgery (<4 vs. >4 weeks) was conducted.

Results

In total, 60 604 patients were analyzed, and 227 (0.4%) patients were diagnosed with SARS-CoV-2 infection preoperatively. The median interval from SARS-CoV-2 infection to surgery was 25 days. Patients diagnosed with SARS-CoV-2 infection preoperatively had a significantly higher incidence of pneumonia (odds ratio: 2.05; 95% confidence interval: 1.05–3.74; p = 0.036) than those not diagnosed with SARS-CoV-2 infection based on the exact logistic regression analysis adjusted for the characteristics of the patients. A similar finding was observed in patients who had SARS-CoV-2 infection <4 weeks before surgery.

Conclusions

Patients with a history of SARS-CoV-2 infection had a significantly higher incidence of pneumonia. This finding can be particularly valuable for countries that have implemented strict regulations in response to the COVID-19 pandemic and have lower SARS-CoV-2 infection-related mortality rates.

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利用日本全国数据库的数据,分析 SARS-CoV-2 感染对胃肠癌术后短期疗效的影响
由于冠状病毒病 2019(COVID-19)的流行,癌症筛查、诊断和治疗都发生了变化。本研究旨在利用日本全国数据库的数据,调查胃肠道癌症手术前感染严重急性呼吸综合征冠状病毒2(SARS-CoV-2)对术后并发症的影响。研究人员分析了2019年7月1日至2022年9月300日期间日本真实世界来源的食管癌、胃癌、结肠癌、直肠癌、肝癌和胰腺癌等癌症手术患者的数据。评估了术前 SARS-CoV-2 感染与术后短期预后之间的关系。共分析了 60 604 例患者,其中 227 例(0.4%)患者术前确诊感染了 SARS-CoV-2。从感染 SARS-CoV-2 到手术的中位间隔为 25 天。根据患者特征调整后的精确逻辑回归分析结果显示,术前确诊感染 SARS-CoV-2 的患者的肺炎发病率(几率比:2.05;95% 置信区间:1.05-3.74;P = 0.036)明显高于未确诊感染 SARS-CoV-2 的患者。在手术前 4 周内感染过 SARS-CoV-2 的患者中也观察到了类似的结果。这一发现对于那些针对 COVID-19 大流行实施了严格规定、SARS-CoV-2 感染相关死亡率较低的国家尤为重要。
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来源期刊
Annals of Gastroenterological Surgery
Annals of Gastroenterological Surgery GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
5.30
自引率
11.10%
发文量
98
审稿时长
11 weeks
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