{"title":"Immune response to infection","authors":"Eilidh Cumming, Christine Peters","doi":"10.1016/j.mpaic.2024.04.003","DOIUrl":null,"url":null,"abstract":"<div><p>The immune system is vital to the body's defence against bacterial, viral and fungal pathogens. An initial defence is provided by the innate immune system. The body's physical barriers are the first line of defence. If these barriers are breached a complex series of chemical, molecular and cellular interactions come into play to protect the body from further assault and tissue damage. Further mechanisms provide future protection through the development of acquired immunity.</p><p>Disruption of these intricate pathways results in a significant risk to the individual and is a common therapeutic challenge for clinicians. The immune system is a constant interplay of pathways that without balance can also lead to clinical compromise and morbidity, for example, through the extremes of overstimulation and development of an anaphylactic reaction or the failure to respond in an immunocompromised patient.</p><p>Recognition and appropriate management of over- and under-activity of the immune system are essential in reducing the risk of harm to patients.</p></div>","PeriodicalId":45856,"journal":{"name":"Anaesthesia and Intensive Care Medicine","volume":"25 6","pages":"Pages 439-443"},"PeriodicalIF":0.2000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anaesthesia and Intensive Care Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1472029924000699","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The immune system is vital to the body's defence against bacterial, viral and fungal pathogens. An initial defence is provided by the innate immune system. The body's physical barriers are the first line of defence. If these barriers are breached a complex series of chemical, molecular and cellular interactions come into play to protect the body from further assault and tissue damage. Further mechanisms provide future protection through the development of acquired immunity.
Disruption of these intricate pathways results in a significant risk to the individual and is a common therapeutic challenge for clinicians. The immune system is a constant interplay of pathways that without balance can also lead to clinical compromise and morbidity, for example, through the extremes of overstimulation and development of an anaphylactic reaction or the failure to respond in an immunocompromised patient.
Recognition and appropriate management of over- and under-activity of the immune system are essential in reducing the risk of harm to patients.
期刊介绍：
Anaesthesia and Intensive Care Medicine, an invaluable source of up-to-date information, with the curriculum of both the Primary and Final FRCA examinations covered over a three-year cycle. Published monthly this ever-updating text book will be an invaluable source for both trainee and experienced anaesthetists. The enthusiastic editorial board, under the guidance of two eminent and experienced series editors, ensures Anaesthesia and Intensive Care Medicine covers all the key topics in a comprehensive and authoritative manner. Articles now include learning objectives and eash issue features MCQs, facilitating self-directed learning and enabling readers at all levels to test their knowledge. Each issue is divided between basic scientific and clinical sections. The basic science articles include anatomy, physiology, pharmacology, physics and clinical measurement, while the clinical sections cover anaesthetic agents and techniques, assessment and perioperative management. Further sections cover audit, trials, statistics, ethical and legal medicine, and the management of acute and chronic pain.
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