{"title":"Auditory Go/NoGo Task in the Dry Immersion Model of Microgravity","authors":"Ivan E. Lazarev","doi":"10.1007/s12217-024-10118-8","DOIUrl":null,"url":null,"abstract":"<p>The effects of a ground-based model of microgravity on executive functions (namely, inhibition) were investigated in this study. Volunteers participated in so-called dry immersion (DI), during which they spent 21 days in a water-filled tub in the supine position. During this period, they performed an auditory Go/NoGo task while multichannel EEG activity was recorded. The Go/NoGo task was performed one time outside of the DI and two times during the stay in the DI. ERPs were computed on correct NoGo and Go trials. While no behavioral deterioration of the Go/NoGo task was found during their stay in the DI, a significant difference was found in amplitudes between NoGo N2 ERP peaks before DI and during DI. The N2 peak was smaller on the 17th day of DI, indicating a potentially lower level of inhibitory control during simulated microgravity conditions. The amplitudes of the N1 and P3 peaks did not change significantly. The dry immersion procedure reproduces some of the important physiological factors of real space flights (support withdrawal, bodily liquid redistribution), thus our results hint at possible brain and behavioral alterations in real space flight that have so far been unnoticed.</p>","PeriodicalId":707,"journal":{"name":"Microgravity Science and Technology","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microgravity Science and Technology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s12217-024-10118-8","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, AEROSPACE","Score":null,"Total":0}
引用次数: 0
Abstract
The effects of a ground-based model of microgravity on executive functions (namely, inhibition) were investigated in this study. Volunteers participated in so-called dry immersion (DI), during which they spent 21 days in a water-filled tub in the supine position. During this period, they performed an auditory Go/NoGo task while multichannel EEG activity was recorded. The Go/NoGo task was performed one time outside of the DI and two times during the stay in the DI. ERPs were computed on correct NoGo and Go trials. While no behavioral deterioration of the Go/NoGo task was found during their stay in the DI, a significant difference was found in amplitudes between NoGo N2 ERP peaks before DI and during DI. The N2 peak was smaller on the 17th day of DI, indicating a potentially lower level of inhibitory control during simulated microgravity conditions. The amplitudes of the N1 and P3 peaks did not change significantly. The dry immersion procedure reproduces some of the important physiological factors of real space flights (support withdrawal, bodily liquid redistribution), thus our results hint at possible brain and behavioral alterations in real space flight that have so far been unnoticed.
本研究调查了地面微重力模型对执行功能（即抑制）的影响。志愿者参加了所谓的 "干浸泡"（DI），在此期间，他们以仰卧姿势在充满水的浴缸中度过了21天。在此期间，他们进行听觉 Go/NoGo 任务，同时记录多通道脑电图活动。Go/NoGo 任务在 DI 外进行一次，在 DI 中进行两次。对正确的 NoGo 和 Go 试验进行了 ERP 计算。虽然在 DI 期间没有发现围棋/NoGo 任务的行为退化，但在 DI 前和 DI 期间，NoGo N2 ERP 峰值的振幅存在显著差异。在 DI 的第 17 天，N2 峰值较小，这表明在模拟微重力条件下，抑制控制水平可能较低。N1和P3峰的振幅没有明显变化。干浸泡程序再现了真实太空飞行中的一些重要生理因素（支持撤出、体液重新分布），因此我们的结果暗示了真实太空飞行中可能存在的大脑和行为改变，而这些改变迄今尚未引起人们的注意。
期刊介绍：
Microgravity Science and Technology – An International Journal for Microgravity and Space Exploration Related Research is a is a peer-reviewed scientific journal concerned with all topics, experimental as well as theoretical, related to research carried out under conditions of altered gravity.
Microgravity Science and Technology publishes papers dealing with studies performed on and prepared for platforms that provide real microgravity conditions (such as drop towers, parabolic flights, sounding rockets, reentry capsules and orbiting platforms), and on ground-based facilities aiming to simulate microgravity conditions on earth (such as levitrons, clinostats, random positioning machines, bed rest facilities, and micro-scale or neutral buoyancy facilities) or providing artificial gravity conditions (such as centrifuges).
Data from preparatory tests, hardware and instrumentation developments, lessons learnt as well as theoretical gravity-related considerations are welcome. Included science disciplines with gravity-related topics are:
− materials science
− fluid mechanics
− process engineering
− physics
− chemistry
− heat and mass transfer
− gravitational biology
− radiation biology
− exobiology and astrobiology
− human physiology
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