Personality traits and polypharmacy: meta-analysis of five samples.

IF 2.4 3区心理学 Q2 PSYCHOLOGY, MULTIDISCIPLINARY Psychology & Health Pub Date : 2024-05-19 DOI:10.1080/08870446.2024.2352182

Yannick Stephan, Angelina R Sutin, Antonio Terracciano

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Abstract

Objective: The present study examined the prospective relationship between personality traits and the risk of polypharmacy.

Methods and measures: Participants (age range: 16-101 years; N > 15,000) were from the English Longitudinal Study of Ageing (ELSA), the Midlife in the United States Study (MIDUS), the Health and Retirement Study (HRS), the Wisconsin Longitudinal Study of Aging (WLS), and the Longitudinal Internet Studies for the Social Sciences (LISS). In each sample, personality traits and demographic factors were assessed at baseline. Number of medications was obtained from 2 to 20 years later.

Results: Random-effect meta-analyses revealed that higher neuroticism was related to a higher risk of polypharmacy (Odd Ratio = 1.30; 95% CI 1.17-1.46) and excessive polypharmacy (Odd Ratio = 1.44; 95% CI 1.18-1.77) whereas higher conscientiousness (Odd Ratio = 0.84; 95% CI 0.74-0.95) and extraversion (Odd Ratio = 0.85; 95% CI 0.73-0.98) were associated with a lower risk of polypharmacy. Openness and agreeableness were unrelated to polypharmacy. Body mass index, number of chronic conditions, and depressive symptoms partially mediated the association between personality and the number of medications.

Conclusion: The present study provides replicable and robust evidence that neuroticism is a risk factor for simultaneous use of multiple medications, whereas conscientiousness and extraversion may play a protective role.

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人格特质与多重用药：对五个样本的元分析。

研究目的本研究探讨了人格特质与多种药物风险之间的前瞻性关系：研究对象（年龄范围：16-101 岁；N > 15,000 人）来自英国老龄化纵向研究（ELSA）、美国中年研究（MIDUS）、健康与退休研究（HRS）、威斯康星老龄化纵向研究（WLS）和社会科学纵向互联网研究（LISS）。在每个样本中，人格特征和人口统计学因素都在基线时进行了评估。结果：随机效应荟萃分析显示，较高的神经质与较高的多药（奇数比=1.30；95% CI 1.17-1.46）和过度多药（奇数比=1.44；95% CI 1.18-1.77）风险有关，而较高的自觉性（奇数比=0.84；95% CI 0.74-0.95）和外向性（奇数比=0.85；95% CI 0.73-0.98）与较低的多药风险有关。开放性和合群性与多重药物治疗无关。体重指数、慢性病数量和抑郁症状对性格与药物数量之间的关系起到了部分中介作用：本研究提供了可复制的有力证据，表明神经质是同时使用多种药物的风险因素，而自觉性和外向性可能起到保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychology & Health Multiple-

CiteScore

7.30

自引率

3.00%

发文量

期刊介绍： Psychology & Health promotes the study and application of psychological approaches to health and illness. The contents include work on psychological aspects of physical illness, treatment processes and recovery; psychosocial factors in the aetiology of physical illnesses; health attitudes and behaviour, including prevention; the individual-health care system interface particularly communication and psychologically-based interventions. The journal publishes original research, and accepts not only papers describing rigorous empirical work, including meta-analyses, but also those outlining new psychological approaches and interventions in health-related fields.