Sex-based Differences in Heart Failure Biomarkers.

IF 3.8 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-05-20 DOI:10.1007/s11897-024-00665-x

Ainhoa Robles-Mezcua, Nelsa González Aguado, Antonia Pilar Martin de la Rosa, Concepción Cruzado-Álvarez, Clara Jiménez Rubio, Alejandro IPérez Cabeza, Juan José Gómez-Doblas, Manuel F Jiménez-Navarro, Mora Murri Pierri, José M García-Pinilla

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Abstract

Purpose of review: Differences in HF biomarker levels by sex may be due to hormonal, genetic, and fat distribution differences. Knowledge of these differences is scarce, and it is not well established whether they may affect their usefulness in the management of HF.

Recent findings: The different biomarker profiles in women and men have been confirmed in recent studies: in women, markers of cardiac stretch and fibrosis (NP and galectin-3) are higher, whereas in men, higher levels of markers of cardiac injury and inflammation (cTn and sST2) are found. The use of new biomarkers, together with growing evidence that a multimarker approach can provide better risk stratification, raises the question of building models that incorporate sex-specific diagnostic criteria. More and more research are being devoted to understanding sex-related differences in HF. The aim of this review is to review the dynamics of HF biomarkers according to sex and in different situations, to learn whether these sex differences may affect their use in the diagnosis and follow-up of HF patients.

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心力衰竭生物标志物的性别差异

综述的目的：高血压生物标志物水平的性别差异可能是由于荷尔蒙、遗传和脂肪分布差异造成的。对这些差异的了解还很少，也没有很好地确定这些差异是否会影响它们在高血压管理中的作用：最近的研究证实了女性和男性不同的生物标志物特征：女性的心脏舒张和纤维化标志物（NP 和 galectin-3）更高，而男性的心脏损伤和炎症标志物（cTn 和 sST2）水平更高。新生物标志物的使用，以及越来越多的证据表明多标志物方法可以提供更好的风险分层，提出了建立包含性别特异性诊断标准的模型的问题。越来越多的研究致力于了解心房颤动与性别有关的差异。本综述旨在回顾不同性别和不同情况下心房颤动生物标志物的动态变化，以了解这些性别差异是否会影响它们在心房颤动患者诊断和随访中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Heart Failure Reports Medicine-Emergency Medicine

CiteScore

5.30

自引率

0.00%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of heart failure. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as investigative, pharmacologic, and nonpharmacologic therapies, pathophysiology, and prevention. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.

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