Growth Factor Cocktail Including Fibroblast Growth Factor 9 (Cellcurin) in the Treatment of Androgenetic Alopecia in Men and Women: A Randomized Controlled Trial.

Q2 Medicine International Journal of Trichology Pub Date : 2023-07-01 Epub Date: 2024-04-05 DOI:10.4103/ijt.ijt_39_21
Leonardo de Medeiros Quirino, Giovana Vilela Rocha
{"title":"Growth Factor Cocktail Including Fibroblast Growth Factor 9 (Cellcurin) in the Treatment of Androgenetic Alopecia in Men and Women: A Randomized Controlled Trial.","authors":"Leonardo de Medeiros Quirino, Giovana Vilela Rocha","doi":"10.4103/ijt.ijt_39_21","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Androgenetic alopecia (AGA) is the most common cause of hair loss in men and women, affecting about 30% of men and 15% of women at 30 years and 80% and 48% at 70 years, respectively. This study aims to assess the effectiveness of growth factor cocktail therapy including fibroblast growth factor 9 (FGF9) (Cellcurin) in men and women with AGA.</p><p><strong>Materials and methods: </strong>This is a single-center randomized controlled trial, conducted with 10 men and 10 women with AGA. Eight men participated in the therapeutic group and two men in the control group. Eight women participated in the therapeutic group and two women in the control group. All were classified by sex, age, duration, and degrees of progression of AGA. The study obtained approval from the Research Ethics Committee (REC) of the Federal University of Uberlandia at approval number: 36918620.8.0000.5152. Six microneedling sessions were performed with an electromedical pen with an interval of 15 days between sessions. In the therapeutic group, sterile injectable Cellcurin was used and, in the control group, injectable sterile minoxidil 5 mg/ml 2 ml, both through the drug delivery system. Trichoscopic photos were taken before and after 12 weeks in the frontal and vertex regions. Descriptive statistics were performed using the <i>t</i>-test with the IBM SPSS-25 software.</p><p><strong>Results: </strong>Men and women showed an expressive and significant increase in the amount of hair per cm<sup>2</sup> after Cellcurin therapy, as well as an increase in the amount of terminal hair, vellus hair, sum of the terminal hair diameters, and mean of the terminal hair diameters in both regions, frontal and vertex.</p><p><strong>Conclusions: </strong>In this study, we demonstrated that the use of Cellcurin in the treatment of AGA in men and women is associated with an increase in the amount of hair per cm<sup>2</sup>, in the amount of terminal hair per cm<sup>2</sup>, in the amount of vellus hair per cm<sup>2</sup>, in the number obtained by the sum of the terminal hair diameters per cm<sup>2</sup>, as well as an increase in the mean diameter of the terminal hairs.</p>","PeriodicalId":14417,"journal":{"name":"International Journal of Trichology","volume":"15 4","pages":"133-143"},"PeriodicalIF":0.0000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11098136/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Trichology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ijt.ijt_39_21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/4/5 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

Abstract

Objectives: Androgenetic alopecia (AGA) is the most common cause of hair loss in men and women, affecting about 30% of men and 15% of women at 30 years and 80% and 48% at 70 years, respectively. This study aims to assess the effectiveness of growth factor cocktail therapy including fibroblast growth factor 9 (FGF9) (Cellcurin) in men and women with AGA.

Materials and methods: This is a single-center randomized controlled trial, conducted with 10 men and 10 women with AGA. Eight men participated in the therapeutic group and two men in the control group. Eight women participated in the therapeutic group and two women in the control group. All were classified by sex, age, duration, and degrees of progression of AGA. The study obtained approval from the Research Ethics Committee (REC) of the Federal University of Uberlandia at approval number: 36918620.8.0000.5152. Six microneedling sessions were performed with an electromedical pen with an interval of 15 days between sessions. In the therapeutic group, sterile injectable Cellcurin was used and, in the control group, injectable sterile minoxidil 5 mg/ml 2 ml, both through the drug delivery system. Trichoscopic photos were taken before and after 12 weeks in the frontal and vertex regions. Descriptive statistics were performed using the t-test with the IBM SPSS-25 software.

Results: Men and women showed an expressive and significant increase in the amount of hair per cm2 after Cellcurin therapy, as well as an increase in the amount of terminal hair, vellus hair, sum of the terminal hair diameters, and mean of the terminal hair diameters in both regions, frontal and vertex.

Conclusions: In this study, we demonstrated that the use of Cellcurin in the treatment of AGA in men and women is associated with an increase in the amount of hair per cm2, in the amount of terminal hair per cm2, in the amount of vellus hair per cm2, in the number obtained by the sum of the terminal hair diameters per cm2, as well as an increase in the mean diameter of the terminal hairs.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
包括成纤维细胞生长因子 9 (Cellcurin) 在内的生长因子鸡尾酒治疗男性和女性雄激素性脱发:随机对照试验》。
目的:雄激素性脱发(AGA)是导致男性和女性脱发的最常见原因,30 岁时约有 30% 的男性和 15% 的女性受到影响,70 岁时分别有 80% 和 48% 的男性和女性受到影响。本研究旨在评估包括成纤维细胞生长因子 9(FGF9)(Cellcurin)在内的生长因子鸡尾酒疗法对男性和女性 AGA 患者的疗效:这是一项单中心随机对照试验,由 10 名男性和 10 名女性 AGA 患者参加。八名男性参加了治疗组,两名男性参加了对照组。治疗组有 8 名女性,对照组有 2 名女性。所有患者均按性别、年龄、病程和 AGA 进展程度分类。该研究获得了乌伯兰迪亚联邦大学研究伦理委员会(REC)的批准,批准号为:36918620.8.0000.5152。研究人员使用电动笔进行了六次微针治疗,每次治疗间隔 15 天。治疗组使用无菌注射用细胞生长因子,对照组使用无菌注射用米诺地尔 5 毫克/毫升 2 毫升,两者均通过给药系统进行。在 12 周前和 12 周后,分别在额头和顶点区域拍摄三维照片。使用 IBM SPSS-25 软件进行描述性统计,采用 t 检验:结果:经过 Cellcurin 治疗后,男性和女性每平方厘米的毛发数量都有了明显的增加,额头和头顶两个区域的末端毛发数量、绒毛数量、末端毛发直径总和以及末端毛发直径平均值也都有了增加:在这项研究中,我们发现使用 Cellcurin 治疗男性和女性的 AGA 会增加每平方厘米的毛发数量、每平方厘米的末端毛发数量、每平方厘米的绒毛数量、每平方厘米末端毛发直径总和的数量以及末端毛发的平均直径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
1.50
自引率
0.00%
发文量
38
期刊最新文献
A Cross-sectional Observational Study to Correlate the Trichoscopic Findings of Female Pattern Hair Loss with the Disease Severity and Underlying Histopathological Changes. A Study of Serum Ferritin and Thyroid-Stimulating Hormone Levels in Male Patients with Androgenetic Alopecia. Alopecia Areata with Renal Dysgenesis. Graham-Little-Piccardi-Lassueur Syndrome with Mucosal Involvement: A Rare Case. Mucinous Lupus Alopecia with Papulonodular Mucinosis as a Sole Cutaneous Manifestation of Systemic Lupus Erythematosus.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1