Autoimmunity and epithelial dysplasia in patients with oral lichenoid diseases.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2024-11-01 Epub Date: 2024-05-19 DOI:10.1111/odi.14988

Jeong-Hyun Kang, Ji Eun Kwon

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Abstract

Objectives: The primary objective of this study was to explore relationship between autoimmunity and epithelial dysplasia in patients with oral lichenoid diseases.

Materials and methods: A total of 66 patients with oral lichen planus (OLP), 35 with oral lichenoid lesion (OLL), and 85 with oral lichenoid drug reaction (OLDR) were enrolled. OLP, OLL, and OLDR were diagnosed following the definitions of the modified World Health Organization criteria, except for the absence of epithelial dysplasia. All patients underwent diagnostic incisional biopsy and adjunctive direct immunofluorescence assays. An indirect immunofluorescence assay was conducted to determine the antinuclear antibody (ANA) positivity.

Results: OLP and OLDR patients with epithelial dysplasia demonstrated higher prevalence of serum ANA positivity compared to those without epithelial dysplasia. Elevated serum levels of high sensitivity-C reactive proteins were observed in the OLP, OLL, and OLDR patients with epithelial dysplasia. In the DIF analysis, patients with epithelial dysplasia in the OLP exhibited a higher prevalence of C3 deposition in the basement membrane zone.

Conclusions: This study proposed that autoimmunity may contribute to elevating levels of focal and chronic systemic inflammation, potentially influencing abnormal wound healing and development of dysplastic changes in the oral epithelium among patients with oral lichenoid disease.

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口腔扁平苔藓患者的自身免疫和上皮发育不良。

研究目的本研究的主要目的是探讨口腔扁平苔藓患者自身免疫与上皮发育不良之间的关系：共纳入 66 名口腔扁平苔藓（OLP）患者、35 名口腔苔癣（OLL）患者和 85 名口腔苔癣药物反应（OLDR）患者。OLP、OLL和OLDR的诊断遵循世界卫生组织的修订标准，但不包括上皮发育不良。所有患者都接受了诊断性切口活检和辅助性直接免疫荧光检测。间接免疫荧光检测用于确定抗核抗体（ANA）阳性：结果：与无上皮发育不良的患者相比，有上皮发育不良的OLP和OLDR患者血清ANA阳性率更高。在上皮发育不良的OLP、OLL和OLDR患者中观察到血清中高灵敏度-C反应蛋白水平升高。在DIF分析中，OLP上皮发育不良患者基底膜区C3沉积率较高：本研究认为，自身免疫可能会导致局灶性和慢性全身性炎症水平升高，从而可能影响口腔扁平苔藓患者伤口的异常愈合和口腔上皮发育不良的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.