Pre-Gestational Obesity and Gestational Weight Gain as Predictors of Childhood Obesity: PROGRESS Cohort from Mexico City

IF 4.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Archives of Medical Research Pub Date : 2024-05-18 DOI:10.1016/j.arcmed.2024.103006
Lucía Hernández-Barrera , Belem Trejo-Valdivia , Martha María Téllez-Rojo , Andrea Baccarelli , Robert Wright , Alejandra Cantoral , Simón Barquera
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Abstract

Objective

To evaluate the associations of pre-gestational body mass index (BMI) and gestational weight gain (GWG) with the risks of overweight, obesity, and adiposity in the first seven years of life in the offspring of a cohort of pregnant women.

Methods

Analysis of 751 mothers and their children participating in the PROGRESS cohort. These women were recruited in Mexico City between 2007 and 2010. Pre-gestational BMI was classified as normal, overweight, and obesity according to the WHO. GWG was calculated as the difference between the last reported pre-pregnancy weight and the pre-gestational weight and categorized as inadequate, adequate, or excessive, according to US IOM recommendations. Children's anthropometry was evaluated at 4–5 and 6–7 years of age. Adiposity was classified into three groups: normal (BMI z-score and waist circumference), overweight (BMI z-score>1), and overweight plus abdominal obesity (OW+AO). A generalized structural equation model (GSEM) was constructed to account for the temporal relationship between variables and to assess direct and indirect effects.

Results

A total of 49.3% of the women had excessive (13.8 ± 4.2 kg) and 19.8% inadequate (3.15 ± 3.4 kg) GWG. Women with pre-gestational overweight or obesity were more likely to have excessive GWG (OR 1.9 [95% CI: 1.32, 2.74] and 3.50 [95% CI: 1.83, 6.69], respectively). In the GSEM, excessive GWG was directly associated with OW+AO at 4–5 years. At 6–7 years, pre-gestational obesity was associated with OW+AO.

Conclusion

Pre-gestational obesity and excessive GWG were independent predictors of childhood obesity.

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妊娠前肥胖和妊娠期体重增加是儿童肥胖的预测因素:墨西哥城 PROGRESS 队列。
目的评估妊娠前体重指数(BMI)和妊娠期体重增加(GWG)与孕妇队列的后代在出生后头 7 年中超重、肥胖和肥胖风险的关系:对参与 PROGRESS 队列的 751 名母亲及其子女进行分析。这些妇女是在 2007 年至 2010 年期间在墨西哥城招募的。根据世界卫生组织的标准,妊娠前体重指数被分为正常、超重和肥胖。根据美国国际移民组织的建议,GWG 的计算方法是最后一次报告的孕前体重与孕前体重之间的差值,并将其分为不足、足够或过多。对 4-5 岁和 6-7 岁儿童的人体测量进行评估。肥胖分为三组:正常(体重指数 z 值和腰围)、超重(体重指数 z 值大于 1)和超重加腹部肥胖(OW+AO)。我们建立了一个广义结构方程模型(GSEM),以考虑变量之间的时间关系,并评估直接和间接效应:结果:49.3%的妇女体重超重(13.8 ± 4.2 千克),19.8%的妇女体重不足(3.15 ± 3.4 千克)。妊娠前超重或肥胖的妇女更容易出现 GWG 超标(OR 分别为 1.9 [95% CI:1.32, 2.74] 和 3.50 [95% CI:1.83, 6.69])。在 GSEM 中,过高的 GWG 与 4-5 岁时的 OW+AO 直接相关。结论:结论:妊娠前肥胖和体重增长过快是儿童肥胖的独立预测因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Archives of Medical Research
Archives of Medical Research 医学-医学:研究与实验
CiteScore
12.50
自引率
0.00%
发文量
84
审稿时长
28 days
期刊介绍: Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.
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