The effects of parenteral fish oil on neurodevelopment in preterm infants: A narrative review

IF 3 Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2024-02-01 DOI:10.1016/j.plefa.2024.102620

N Ikeda , E Shepherd , M Makrides , A J McPhee , RA Gibson , JF Gould

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Abstract

Objective

This narrative review aimed to summarize studies assessing the effects of parenteral fish oil on neurodevelopment in preterm infants.

Methods

PubMed was searched (July 1985 to October 2023). We reviewed randomized controlled trials, and observational studies assessing intravenous lipid emulsion with fish oil in preterm infants (born less than 37 weeks’ gestation), that reported long-term neurodevelopmental outcomes.

Results

We identified four publications relating to three randomized controlled trials in addition to four cohort studies. Study designs and outcomes were heterogenous and precluded meta-analyses. Results of trials were null for a selection of neurodevelopmental outcomes, however possible benefits of parenteral fish oil supplementation for neurodevelopment was reported in three cohort studies. Certainty of the evidence is hindered by methodological limitations of available trials and observational studies.

Conclusions

Further research is required to firmly establish the effects of parenteral fish oil on preterm neurodevelopment.

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肠外鱼油对早产儿神经发育的影响：叙述性综述。

目的：本综述旨在总结评估肠外鱼油对早产儿神经发育影响的研究：本叙述性综述旨在总结评估肠外鱼油对早产儿神经发育影响的研究：检索了 PubMed（1985 年 7 月至 2023 年 10 月）。我们回顾了随机对照试验和观察性研究，这些研究评估了静脉注射鱼油脂质乳剂对早产儿（妊娠不足 37 周）神经发育的长期影响：我们发现了四篇出版物，涉及三项随机对照试验和四项队列研究。研究设计和结果各不相同，因此无法进行荟萃分析。部分神经发育结果的试验结果为零，但有三项队列研究报告了肠外补充鱼油可能对神经发育有益。现有试验和观察性研究在方法上的局限性妨碍了证据的确定性：结论：要确定肠外鱼油对早产儿神经发育的影响，还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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