Epidemiological study of hepatitis E virus infection among students and workers in Hebei Province of China

IF 2.4 2区农林科学 Q3 INFECTIOUS DISEASES Zoonoses and Public Health Pub Date : 2024-05-20 DOI:10.1111/zph.13154

Huan Liu, Kunjing Geng, Chunyan Wang, Tengfei Shi, Hongxin Zhang, Chenyan Zhao, Yansheng Geng

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Abstract

Aims

Hepatitis E caused by the hepatitis E virus (HEV) is prevalent worldwide. In China, considerable shifts in the epidemiology of hepatitis E have been observed over the last two decades, with ongoing changes in the prevalence of HEV.

Methods

This study, in conjunction with the health examinations for students and workers, aims to estimate the seroprevalence and assess the risk factors of HEV infection in general population in Hebei province, China. Epidemiological information was collected using a specific questionnaire and blood samples were collected from each participant during the process of health examination. Anti-HEV IgG and IgM in sera were tested using the Wantai ELISA assay kits. Logistic regression modelling was used to identify associated risk factors.

Results

The average positive rate of anti-HEV IgG in students (6–25 years) was 3.4%. One (0.2%) student was anti-HEV IgM positive, while also testing positive for IgG. The HEV seroprevalence was not related to students' gender, school, or family residence. In occupational populations, the overall seropositivity rate was 13.3% for anti-HEV IgG and 0.67% for IgM. HEV seropositivity increased significantly with age, ranging from 3.8% to 18.6% in age groups, and differed significantly among four occupation groups: farmers (17.6%), food supply workers (18.0%), other non-farm workers (14.7%) and healthcare workers (5.9%) (p = 0.002). Multivariable logistic analysis confirmed the significant correlations of seroprevalence with age and occupation.

Conclusions

The study found a low seroprevalence of HEV in children and young adults in Hebei Province, China. Advanced age correlates with higher seroprevalence in occupational populations, indicating an accumulation of HEV infection over time. Seroprevalence varied significantly among different occupation groups, suggesting the important role of occupational exposure for HEV infection.

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中国河北省学生和工人戊型肝炎病毒感染的流行病学研究。

目的：由戊型肝炎病毒（HEV）引起的戊型肝炎在全球流行。在中国，戊型肝炎的流行病学在过去二十年中发生了很大变化，戊型肝炎病毒的流行率也在不断变化：本研究结合学生和工人的健康检查，旨在估算中国河北省普通人群的血清流行率，并评估 HEV 感染的风险因素。研究采用特定的调查问卷收集流行病学信息，并在体检过程中采集每位受试者的血样。使用万泰 ELISA 检测试剂盒检测血清中的抗 HEV IgG 和 IgM。采用逻辑回归模型确定相关风险因素：学生（6-25 岁）抗 HEV IgG 平均阳性率为 3.4%。一名（0.2%）学生的抗 HEV IgM 阳性，同时 IgG 也呈阳性。HEV 血清流行率与学生的性别、学校或家庭居住地无关。在职业人群中，抗-HEV IgG 的总体血清阳性率为 13.3%，IgM 为 0.67%。HEV血清阳性率随年龄的增长而显著增加，各年龄组的阳性率从3.8%到18.6%不等，四个职业组的阳性率差异显著：农民（17.6%）、食品供应人员（18.0%）、其他非农工作者（14.7%）和医疗保健人员（5.9%）（P = 0.002）。多变量逻辑分析证实血清阳性率与年龄和职业有显著相关性：研究发现，中国河北省儿童和青壮年的 HEV 血清流行率较低。在职业人群中，高龄与较高的血清流行率相关，这表明 HEV 感染会随着时间的推移而累积。不同职业群体的血清流行率差异显著，表明职业暴露在 HEV 感染中发挥着重要作用。

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来源期刊

Zoonoses and Public Health 医学-传染病学

CiteScore

5.30

自引率

4.20%

发文量

115

审稿时长

6-12 weeks

期刊介绍： Zoonoses and Public Health brings together veterinary and human health researchers and policy-makers by providing a venue for publishing integrated and global approaches to zoonoses and public health. The Editors will consider papers that focus on timely collaborative and multi-disciplinary research in zoonoses and public health. This journal provides rapid publication of original papers, reviews, and potential discussion papers embracing this collaborative spirit. Papers should advance the scientific knowledge of the sources, transmission, prevention and control of zoonoses and be authored by scientists with expertise in areas such as microbiology, virology, parasitology and epidemiology. Articles that incorporate recent data into new methods, applications, or approaches (e.g. statistical modeling) which enhance public health are strongly encouraged.