The iron(III) coordinating properties of citrate and α-hydroxycarboxylate containing siderophores.

IF 4.1 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biometals Pub Date : 2024-05-21 DOI:10.1007/s10534-024-00607-z
Robert C Hider, André M N Silva, Agostino Cilibrizzi
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Abstract

The iron(III) binding properties of citrate and rhizoferrin, a citrate containing siderophore, are compared. Citrate forms many oligonuclear complexes, whereas rhizoferrin forms a single mononuclear complex. The α-hydroxycarboxylate functional group, which is present in both citrate, and rhizoferrin, has a high affinity and selectivity for iron(III) under most biological conditions. The nature of the toxic form of iron found in the blood of patients suffering from many haemoglobinopathies and haemochromatosis is identified as a mixture of iron(III)citrate complexes. The significance of the presence of this iron pool to patients suffering from systemic iron overload is discussed. The wide utilisation of the α-hydroxycarboxylate functional group in siderophore structures is described, as is their photo-induced decarboxylation leading to the release of iron(II) ions. The importance of this facile dissociation to algal iron uptake is discussed.

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含柠檬酸盐和α-羟基羧酸盐的铁(III)配位特性。
比较了柠檬酸铁和根瘤铁蛋白(一种含柠檬酸铁的铁素体)的铁(III)结合特性。柠檬酸盐形成许多寡核络合物,而根瘤铁蛋白则形成单一的单核络合物。柠檬酸盐和根瘤铁蛋白中都含有α-羟基羧酸官能团,在大多数生物条件下,α-羟基羧酸官能团对铁(III)具有很高的亲和力和选择性。在许多血红蛋白病和血色素沉着病患者血液中发现的毒性铁的性质被确定为柠檬酸铁(III)络合物的混合物。本文讨论了这种铁库的存在对全身铁超载患者的意义。介绍了α-羟基羧酸官能团在嗜苷酸盐结构中的广泛应用,以及光诱导脱羧导致铁(II)离子释放的情况。讨论了这种容易解离对藻类铁吸收的重要性。
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来源期刊
Biometals
Biometals 生物-生化与分子生物学
CiteScore
5.90
自引率
8.60%
发文量
111
审稿时长
3 months
期刊介绍: BioMetals is the only established journal to feature the important role of metal ions in chemistry, biology, biochemistry, environmental science, and medicine. BioMetals is an international, multidisciplinary journal singularly devoted to the rapid publication of the fundamental advances of both basic and applied research in this field. BioMetals offers a forum for innovative research and clinical results on the structure and function of: - metal ions - metal chelates, - siderophores, - metal-containing proteins - biominerals in all biosystems. - BioMetals rapidly publishes original articles and reviews. BioMetals is a journal for metals researchers who practice in medicine, biochemistry, pharmacology, toxicology, microbiology, cell biology, chemistry, and plant physiology who are based academic, industrial and government laboratories.
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