Seminal plasma hypersensitivity: A systematic review of clinical presentation, diagnostics, and management options

IF 2.5 3区 医学 Q3 IMMUNOLOGY American Journal of Reproductive Immunology Pub Date : 2024-05-22 DOI:10.1111/aji.13865
Kayla Schacher, Mudar Dalloul, Ozgul Muneyyirci-Delale
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Abstract

Introduction

Seminal plasma hypersensitivity (SPH) is a rare and often misdiagnosed condition characterized by local and/or systemic reactions to seminal plasma proteins following exposure to semen. We aimed to summarize key symptomatology, diagnostic features, and management options for SPH.

Methods

The databases PubMed, EMBASE, Web of Science, Google Scholar, and Cochrane Review were searched with key words “seminal plasma hypersensitivity” and “seminal fluid allergy” through September 2023. Exclusion criteria included non-English articles, in vitro studies, publication before 1990, duplicates, and articles with no clinical relevance to SPH in women.

Results

The search yielded 53 articles for review. Of these, 60.5% described systemic SPH and 39.5% described localized.

Conclusion

Diagnosis of SPH relies on a thorough patient history and confirmatory skin prick testing. The use of IgE assays is controversial and less accurate for cases of localized SPH. Knowledge of disease immunopathology, systemic versus localized symptom presentation, patient preference, and desire to conceive should guide management options. Artificial insemination has the potential for severe adverse reactions in systemic SPH so necessitates extra procedural precautions. SPH does not appear to impair fertility. Additional research on specific allergens implicated in SPH can aid in the development of more targeted immunotherapy approaches with improved safety and efficacy.

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精浆过敏症:临床表现、诊断和治疗方案的系统回顾。
简介:精浆过敏症(SPH)是一种罕见且经常被误诊的疾病,其特征是接触精液后对精浆蛋白产生局部和/或全身反应。我们旨在总结 SPH 的主要症状、诊断特征和治疗方案:方法:以 "精浆过敏 "和 "精液过敏 "为关键词,检索了 PubMed、EMBASE、Web of Science、Google Scholar 和 Cochrane Review 等数据库,检索期至 2023 年 9 月。排除标准包括非英文文章、体外研究、1990 年之前发表的文章、重复文章以及与女性 SPH 无临床相关性的文章:结果:检索结果显示有 53 篇文章可供查阅。其中,60.5%描述了全身性SPH,39.5%描述了局部性SPH:结论:SPH 的诊断依赖于详尽的病史和确诊性皮肤点刺试验。结论:SPH 的诊断有赖于详尽的病史和确凿的皮肤点刺试验。IgE 检测的使用存在争议,而且对局部 SPH 病例的准确性较低。对疾病免疫病理、全身症状与局部症状表现、患者偏好和受孕愿望的了解应指导治疗方案的选择。人工授精有可能对全身性 SPH 造成严重的不良反应,因此必须采取额外的预防措施。SPH 似乎不会影响生育能力。对与 SPH 相关的特定过敏原进行更多研究有助于开发更具针对性的免疫疗法,从而提高安全性和有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.20
自引率
5.60%
发文量
314
审稿时长
2 months
期刊介绍: The American Journal of Reproductive Immunology is an international journal devoted to the presentation of current information in all areas relating to Reproductive Immunology. The journal is directed toward both the basic scientist and the clinician, covering the whole process of reproduction as affected by immunological processes. The journal covers a variety of subspecialty topics, including fertility immunology, pregnancy immunology, immunogenetics, mucosal immunology, immunocontraception, endometriosis, abortion, tumor immunology of the reproductive tract, autoantibodies, infectious disease of the reproductive tract, and technical news.
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