American Journal of Reproductive Immunology最新文献

{"title":"Human Leukocyte Antigen Haplotypes Predisposing to Celiac Disease in Patients With Endometriosis","authors":"Silvia Vannuccini,&nbsp;Virginia Manzi,&nbsp;Mirko Tarocchi,&nbsp;Nico Donati,&nbsp;Francesco La Torre,&nbsp;Federico Toscano,&nbsp;Antonino Salvatore Calabrò,&nbsp;Felice Petraglia","doi":"10.1111/aji.70079","DOIUrl":"https://doi.org/10.1111/aji.70079","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Problem</h3>\u0000 \u0000 <p>Immunological abnormalities are well recognized in the pathogenesis of endometriosis and the co-existence of endometriosis with inflammatory bowel disease (IBD) and celiac disease (CD), along with other systemic immune disorders, is clinically relevant. Recent genetic studies revealed some shared genetic traits associated with the co-occurrence of endometriosis with different gastrointestinal or autoimmune disorders, highlighting common biological pathways. Since class II human leukocyte antigen (HLA) genes, HLA-DQ2 and -DQ8, show the strongest and best-characterized genetic susceptibility for CD, the present study aims to explore the presence of these haplotypes in non-celiac patients with endometriosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method of Study</h3>\u0000 \u0000 <p>A group of patients with endometriosis (<i>n</i> = 126) participated in the study and were compared to healthy women (<i>n</i> = 379), as controls. Subjects who were diagnosed with CD or who tested positive for CD antibodies were excluded. All patients and controls were genotyped for HLA haplotypes predisposing to CD (DQ2, DQ8). In the group of endometriosis patients who tested positive for DQ2 and/or DQ8, symptoms were also investigated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At least one of the HLA-DQ2 and -DQ8 genotypes was detected in 43.3% of non-celiac endometriosis patients (OR: 1.82, 95% CI: 1.11–2.81), whereas 29.5% (<i>p</i> &lt; 0.01) of healthy women presented HLA haplotypes predisposing to CD. In endometriosis patients, no significant difference was shown between positive and negative in terms of endometriosis phenotype, or gynecological, and non-gynecological symptoms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our data revealed a significantly greater prevalence of predisposing haplotypes for CD in non-celiac patients with endometriosisthan in healthy subjects, suggesting that a common genetic background may explain the co-occurrence of endometriosis and CD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aji.70079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding a Potential Role for the NLRP3 Inflammasome in Placenta-Mediated Pregnancy Complications","authors":"Chloe G. Moss,&nbsp;Mark R. Dilworth,&nbsp;Lynda K. Harris,&nbsp;Sally Freeman,&nbsp;Alexander E. P. Heazell","doi":"10.1111/aji.70077","DOIUrl":"https://doi.org/10.1111/aji.70077","url":null,"abstract":"<p>Stillbirth affects approximately 2 million pregnancies annually and is closely linked to placental dysfunction, which may also present clinically as foetal growth restriction (FGR) or pre-eclampsia (PE). Placental dysfunction can arise from a range of insults, including the inflammatory conditions villitis of unknown aetiology (VUE) and chronic histiocytic intervillositis (CHI). Despite ample research regarding the pathophysiology of placental dysfunction, the literature surrounding placental inflammation is more limited, with no currently established treatments. In the absence of infection, placental inflammation is hypothesised to be stimulated by damage-associated molecular patterns (DAMPs), known as sterile inflammation. The NLRP3 inflammasome, a protein scaffold that unites within the cytosol of cells, is a proposed contributor. The NLRP3 inflammasome is dysregulated in numerous diseases and has shown evidence of activation through the sterile inflammatory pathway via DAMPs. Studies have demonstrated the upregulation of the NLRP3 inflammasome and its components in placentally-mediated pregnancy pathologies. However, the link between placental dysfunction seen in these disorders and the NLRP3 inflammasome is not yet firmly established. This manuscript aims to review the evidence regarding placental inflammation seen with placental dysfunction, discuss its association with the NLRP3 inflammasome, and identify potential therapeutic interventions for this pathological inflammatory response.</p>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aji.70077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Indices in First Trimester as Predictors of Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes","authors":"Yu Sun,&nbsp;Cuihua Shen,&nbsp;Jia Li,&nbsp;Wei Kang,&nbsp;Xin Li,&nbsp;Wei Fan","doi":"10.1111/aji.70070","DOIUrl":"https://doi.org/10.1111/aji.70070","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To explore the association between systemic inflammatory markers (systemic inflammation response index [SIRI], systemic immune inflammation index [SII], interleukin [IL]-33, and soluble tumorigenicity 2 [sST2]) and gestational diabetes mellitus (GDM), as well as adverse pregnancy outcomes (APOs), and to assess the impact of glycemic control on these relationships.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 777 participants were included, comprising 476 women with GDM and 301 without. Clinical characteristics, inflammatory markers, and pregnancy outcomes were analyzed. Logistic regression was employed to assess the risk of GDM and APOs associated with elevated inflammatory indices and glycemic control. Diagnostic performance was evaluated using receiver operating characteristic (ROC) curves.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Women with GDM exhibited significantly higher levels of SII, SIRI, IL-33, and sST2. Multivariate logistic regression demonstrated that SII, SIRI, IL-33, and sST2 were independent predictors of GDM. Moreover, the highest tertiles of SII, SIRI, and IL-33 were strongly associated with APO risk. ROC analysis revealed that SII had the highest predictive value for GDM (AUC 0.763), while IL-33 had the greatest predictive accuracy for APOs (AUC 0.669). Effective glycemic control was associated with reduced inflammatory marker levels (SII, aOR 3.9; SIRI, aOR 3.7; IL-33, aOR 2.4) and a decreased risk of APOs and large-for-gestational-age (LGA) infants in women with GDM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Elevated SII, SIRI, IL-33, and sST2 are significant predictors of GDM and APOs, with SII being the most robust predictor of GDM and IL-33 for APOs. Glycemic control reduces inflammation and may improve pregnancy outcomes in women with GDM.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of COVID-19 Infection During Pregnancy on the Plasma/Extracellular Vesicles Pro-Inflammatory Cytokine Profile","authors":"C. Heeralall,&nbsp;Usri H. Ibrahim,&nbsp;M. Jenneker,&nbsp;S. Singh,&nbsp;L. Lazarus,&nbsp;Irene Mackraj","doi":"10.1111/aji.70071","DOIUrl":"https://doi.org/10.1111/aji.70071","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The Coronavirus disease (COVID-19) has impacted pregnant women significantly, with increased mortality and morbidity. The implications of this virus are linked to extracellular vesicles (EVs) and maternal inflammation due to the cytokine storm. Hence, this study aims to investigate the impact of COVID-19 on the pro-inflammatory cytokine profile in both plasma and EVs of South African pregnant women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Plasma samples were obtained from pregnant women in the third trimester, from which EVs were extracted using the Invitrogen Total Exosome Isolation Kit. These plasma-derived EVs were characterised using transmission electron microscopy and nanoparticle tracking analysis (NTA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>COVID-19 infection in pregnancy did not significantly affect the average particle size and concentration of isolated EVs. The levels of IFN gamma, IL-6, MIP-1 alpha and TNF alpha were analysed in the plasma and circulating EVs through a multiplex assay. Compared to the control group, a significant increase in IL-6, IFN-γ, TNF-α and MIP-1α levels were observed in both plasma and EVs content of COVID-19 pregnancies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings suggest that COVID-19 infection impacts the pro-inflammatory cytokine profile in the plasma and EVs of South African pregnant women.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aji.70071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body Fat Distribution and Glucose Homeostasis Is Affected by Perinatal Exposure to High Dietary Advanced Glycation End Products (AGEs) in Male Offspring","authors":"Zaher Merhi,&nbsp;Xiu Quan Du,&nbsp;Maureen J. Charron","doi":"10.1111/aji.70073","DOIUrl":"https://doi.org/10.1111/aji.70073","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Problem</h3>\u0000 \u0000 <p>Exposures during the perinatal period, a phase of rapid development and growth, may have a profound and sustained effect on metabolic disturbances later in life. The pro-inflammatory advanced glycation end products (AGEs) are widely consumed in the Western diet. The purpose of this study was to determine whether perinatal exposure to these dietary AGEs alters metabolic parameters, in particular adiposity and glucose hemostasis, in male mice offspring.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Seven-week-old female CD1 mice were placed before mating and then throughout pregnancy and lactation on either a low AGE (L-AGE; <i>n</i> = 13) or high AGE (H-AGE; <i>n</i> = 13) diet. All offspring in both groups were weaned postnatal day 21 onto normal diet and studied through to 21 weeks of age. The offspring were counted and weighed weekly, starting at birth until 21 weeks of age, to assess the growth curve. At the time of sacrifice, Echo MRI was performed to measure adiposity and to record liver, white epididymal adipose tissue (WAT), and inguinal fat weights. Serum levels of leptin as well as insulin and glucose tolerance tests (ITT and GTT) were compared.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The Body weight at birth of offspring of dams that were on H-AGE diet was significantly lower compared to the body weight of offspring of dams that were on L-AGE diet. Echo MRI data showed that the offspring of dams that were H-AGE diet had significantly lower fat mass, lower epididymal WAT fat weight, and lower inguinal fat weight but higher lean body mass and similar liver weight. They also had significantly higher glucose levels during GTT and ITT, as well as significantly lower serum leptin levels compared to the offspring of dams that were on the L-AGE diet.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These results indicate that perinatal exposure to a maternal diet elevated in AGEs causes deficits in perinatal growth and impairment in glucose hemostasis in male mice. These findings suggest that AGEs may represent an important new class of mediators of adiposity and the metabolic syndrome.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive Outcomes of Women With Endometrial Fluid During IVF-ICSI Treatment: A Single-Center Experience","authors":"Burcu Tas Uzun,&nbsp;Emine Sen Bicak,&nbsp;Erinc Tekin,&nbsp;Hasan Ali Inal,&nbsp;Mete Caglar","doi":"10.1111/aji.70072","DOIUrl":"https://doi.org/10.1111/aji.70072","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To retrospectively evaluate whether endometrial fluid detected at transvaginal ultrasonography on the third day of the menstrual cycle in infertile patients undergoing in vitro fertilization/intracytoplasmic sperm injection–embryo transfer (IVF-ICSI/ET) affects pregnancy outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 148 patients who had undergone IVF-ICSI between 2010 and 2017 were included in this study. The participants were stratified according to the presence of endometrial fluid: Group 1 (control; <i>n</i> = 74) consisted of women without endometrial fluid and Group 2 (study; <i>n</i> = 74) of those with endometrial fluid. Baseline sociodemographic characteristics and reproductive outcomes were compared between the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No difference was found between the groups in terms of age, body mass index, smoking rates, duration of infertility, etiology of infertility, baseline follicle-stimulating hormone, luteinizing hormone, estradiol, thyroid-stimulating hormone, and prolactin levels, duration of stimulation, stimulation protocol, antral follicle counts, total gonadotropin doses, peak E₂ and progesterone levels on the day of human chorionic gonadotropin (hCG) administration, or endometrial thickness at hCG administration and the day of transfer (<i>p</i> &gt; 0.05). The number of oocytes retrieved, metaphase II oocytes, two pronuclei, fertilization rates, and the rates of Grade I embryos per woman, as well as pronucleus counts, were comparable between the groups (<i>p</i> &gt; 0.05). However, the clinical pregnancy rate (CPR) (47.3% vs. 31.1%) and live birth rate (LBR) (41.9% vs. 24.3%) were both significantly lower in women with endometrial fluid compared to the control group (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This retrospective cohort study shows that the women with endometrial fluid in their IVF-ICSI/ET cycles exhibited lower CPR and LBR. Further prospective studies are needed to confirm the validity of our results.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of First-Trimester Aggregate Index of Systemic Inflammation (AISI) and Other Inflammatory Indices for Gestational Diabetes Mellitus and Associated Obstetric Outcomes","authors":"Esra Karatas,&nbsp;Atakan Tanacan,&nbsp;Osman Onur Ozkavak,&nbsp;Burcu Bozkurt Ozdal,&nbsp;Hatice Betul Ucar,&nbsp;Ozgur Kara,&nbsp;Dilek Sahin","doi":"10.1111/aji.70069","DOIUrl":"https://doi.org/10.1111/aji.70069","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Problem</h3>\u0000 \u0000 <p>To investigate the value of the first-trimester aggregate index of systemic inflammation (AISI) and other combined inflammatory markers in the prediction of gestational diabetes mellitus (GDM) and related obstetric outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method of Study</h3>\u0000 \u0000 <p>The data of pregnant women diagnosed with GDM between September 2021 and November 2024, as well as an equal number of control patients, were retrospectively analyzed. The patients' AISI, neutrophil lymphocyte ratio (NLR), systemic immune-inflammatory index (SII), and systemic inflammatory response index (SIRI) values were calculated from the hemogram parameters of the participants at 11–14 weeks of gestation. The clinical characteristics, laboratory results, combined inflammatory indices, obstetric outcomes, the need for neonatal intensive care unit (NICU) admission, and the presence of composite adverse perinatal outcome (CAPO) of the groups were then compared. Receiver operating characteristic (ROC) curve analyses were performed to investigate the value of the indices that reached statistical significance in predicting GDM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The GDM group exhibited significantly higher SII and AISI values, rate of NICU admission, and CAPO compared to the control group (<i>p</i> = 0.036, <i>p</i> = 0.011, <i>p </i>&lt; 0.01, and <i>p </i>&lt; 0.01, respectively). The gestational age at birth was significantly lower in the GDM group compared to the control group, while the neonatal weight was higher (<i>p </i>&lt; 0.01, <i>p </i>&lt; 0.01, respectively). The ROC curve analyses yielded an area under the curve (AUC) of 0.566 and 0.581 for SII and AISI for GDM prediction, respectively (<i>p</i> = 0.036 and <i>p</i> = 0.011, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>First-trimester AISI and SII may be useful markers for identifying pregnancies at high risk for developing GDM.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Serum Inflammatory Biomarkers During Pregnancy With Placental Pathology and Placental Gene Expression at Delivery","authors":"Linda M. Ernst,&nbsp;Alexa A. Freedman,&nbsp;Renee M. Odom-Konja,&nbsp;Lauren Keenan-Devlin,&nbsp;Gregory E. Miller,&nbsp;Steve Cole,&nbsp;Amy Crockett,&nbsp;Ann Borders","doi":"10.1111/aji.70062","DOIUrl":"https://doi.org/10.1111/aji.70062","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Problem</h3>\u0000 \u0000 <p>We sought to investigate whether maternal inflammatory cytokines during pregnancy are associated with histologic inflammatory or vascular lesions in the placenta and/or correlated with gene expression patterns in the placenta.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method of Study</h3>\u0000 \u0000 <p>We leveraged data from a large randomized controlled trial (RCT) at a single site. Maternal serum was collected in the second and third trimesters, and a composite inflammatory score was created using five measured biomarkers (CRP, IL-6, IL-1ra, IL-10, and TNF-α). Placentas were collected at delivery for histological analysis and four major patterns of placental injury were characterized. Fresh small chorionic villous biopsies were collected for placental genome-wide mRNA profiling. Transcripts showing &gt;2-fold differential expression over the 4-SD range of circulating inflammatory biomarkers were reported, adjusting for potential confounders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The primary analysis included 601 participants. A one standard deviation increase in the third-trimester inflammatory composite was associated with increased odds of chronic inflammation in the placenta (OR: 1.23, 95% CI 1.01, 1.51;). This was driven primarily by elevations in IL-10 (OR: 1.37; 99% CI: 1.06, 1.77). Higher maternal IL-10 in circulation was associated with bioinformatic indications of reduced pro-inflammatory gene regulation pathways in the placenta (AP1 decreased 25%, <i>p</i> = 0.003; NF-kB decreased 53%, <i>p</i> = 0.003) and indications of increased STAT family signaling pathways which mediate signaling through the IL-10 receptor (increased 73%, <i>p</i> = 0.002).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our results indicate that elevated maternal circulating IL-10 during pregnancy is associated with chronic inflammatory lesions in the placenta at delivery. Additionally, higher levels of circulating IL-10 are associated with upregulated STAT signaling pathways in placental tissues.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aji.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunopathology of Endometriosis, Molecular Approaches","authors":"Sima Amidifar,&nbsp;Davood Jafari,&nbsp;Amir Hossein Mansourabadi,&nbsp;Sara Sadaghian,&nbsp;Abdolreza Esmaeilzadeh","doi":"10.1111/aji.70056","DOIUrl":"https://doi.org/10.1111/aji.70056","url":null,"abstract":"<div>\u0000 \u0000 <p>Endometriosis (EMS) is a common chronic gynecological disorder affecting 5%–10% of reproductive-age women, often causing infertility, dyspareunia, pain, and limitations in physical and sexual activities. This condition is defined by the presence of endometrial tissue outside the uterus, commonly explained by Sampson's theory of retrograde menstruation. Although its etiology remains unclear, genetic, epigenetic, hormonal imbalances, oxidative stress, and immune factors play critical roles. Immune dysregulation, involving inflammatory factors, cytokines, and immune cells facilitates the implantation, proliferation, angiogenesis, and development of ectopic endometrial stromal cells (ESCs). Research indicates that the implantation of ESCs in the peritoneum triggers an inflammatory response, recruiting various immune cells and leading to a cycle of inflammation characterized by elevated growth factors and cytokines. In this review, we discuss the immune system's role in EMS pathogenesis, emphasizing the contributions of immune cells, inflammatory mediators, oxidative stress, and so forth. This review also highlights that while current treatments, including hormonal therapies and surgical interventions, aim to alleviate symptoms and improve fertility, emerging evidence suggests that advancements in immunotherapies targeting specific immune cell activities hold promise as innovative future treatment strategies enhancing healthcare management for affected women.</p>\u0000 </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Decrease of Antibodies Against SARS-CoV-2 Antigens Does Not Reflect a Decrease of Neutralization Rate: Comment","authors":"Hinpetch Daungsupawong,&nbsp;Viroj Wiwanitkit","doi":"10.1111/aji.70068","DOIUrl":"https://doi.org/10.1111/aji.70068","url":null,"abstract":"","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"93 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}