An overview of the differences in the pharmacological management of post-traumatic stress disorder between women and men.

IF 3.4 2区 医学 Q2 CLINICAL NEUROLOGY Expert Review of Neurotherapeutics Pub Date : 2024-06-01 Epub Date: 2024-05-21 DOI:10.1080/14737175.2024.2355259
Donatella Marazziti, Lara Foresi Crowther, Alessandro Arone
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Abstract

Introduction: Post-traumatic stress disorder (PTSD) is a disabling psychiatric condition with a worldwide prevalence between 6% and 9%, and more common in the female than in the male sex. The aim of this paper is to review and comment on the different factors that might explain the discrepancies in the pharmacological management of women and men.

Areas covered: The available literature shows that there exists a vulnerability of women to develop PTSD that may depend on neurobiological as well as environmental/cultural factors. These variables might influence the clinical picture, the outcome and the response to specific treatments, given their consequences on the pharmacokinetics of commonly prescribed drugs. Women suffering from PTSD are more prone to consult and receive more prescriptions of psychotropic drugs than men. However, it is evident that the particular stages of a women's life such as pregnancy or breastfeeding might require a specific evaluation and care.

Expert opinion: It is necessary to explore the pharmacokinetics of compounds highlighting sex-related differences, and their safety during pregnancy and lactation. Taking care of differences between women and men should represent a main focus of research, while being a primary target towards a really tailored pharmacological treatment of PTSD.

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概述男女在创伤后应激障碍药物治疗方面的差异。
导言创伤后应激障碍(PTSD)是一种致残性精神病,全球发病率在 6% 到 9% 之间,女性发病率高于男性。本文旨在回顾和评论可能造成男女药物治疗差异的不同因素:现有文献表明,女性易患创伤后应激障碍,这可能取决于神经生物学和环境/文化因素。这些变量可能会影响临床表现、治疗结果和对特定治疗的反应,因为它们会对常用处方药的药代动力学产生影响。与男性相比,患有创伤后应激障碍的女性更容易就诊并获得更多的精神药物处方。不过,很明显,妇女在怀孕或哺乳等特殊阶段可能需要特殊的评估和护理:专家意见:有必要研究化合物的药代动力学,突出与性别有关的差异,以及在妊娠和哺乳期间的安全性。关注女性和男性之间的差异应成为研究的重点,同时也应成为对创伤后应激障碍进行真正量身定制的药物治疗的主要目标。
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来源期刊
Expert Review of Neurotherapeutics
Expert Review of Neurotherapeutics Medicine-Neurology (clinical)
CiteScore
7.00
自引率
2.30%
发文量
61
审稿时长
4-8 weeks
期刊介绍: Expert Review of Neurotherapeutics (ISSN 1473-7175) provides expert reviews on the use of drugs and medicines in clinical neurology and neuropsychiatry. Coverage includes disease management, new medicines and drugs in neurology, therapeutic indications, diagnostics, medical treatment guidelines and neurological diseases such as stroke, epilepsy, Alzheimer''s and Parkinson''s. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points
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