Application of the Milan system for reporting salivary gland cytopathology to core needle biopsies of the parotid gland

IF 3.9 2区医学 Q2 CELL BIOLOGY Histopathology Pub Date : 2024-05-21 DOI:10.1111/his.15200

Anna-Karoline Israel, Christopher C Griffith

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Abstract

Aims

The Milan system for reporting salivary gland cytopathology was developed by an international group of experts and first published in 2018 with the goal to standardise reporting of salivary gland aspirates. Seven categories with distinct risks of malignancy were proposed. Core needle biopsies (CNB) of salivary glands are also common, but reporting lacks standardisation. Here we explore the feasibility of a Milan-like reporting system on CNB of the parotid gland.

Methods and results

Our laboratory information system was searched for parotid gland CNBs from 2010 to 2021. Reports were translated into a Milan-like reporting system. When available, CNB findings were correlated with cytology and resection specimens. In order to compare the performance of CNB with fine-needle aspirations (FNA), we established a second cohort of cases consisting of parotid FNA with surgical follow-up. The risk of neoplasia (RON) and risk of malignancy (ROM) was calculated for FNA and CNB Milan categories using cases with follow-up resection. We analysed 100 cases of parotid gland CNB. Of these cases, 32 underwent subsequent resection, while 52 had concurrent FNA. A total of 20 cases had concurrent FNA and underwent follow-up resection. In 63 (63%) cases, a specific diagnosis was provided on CNB, with 18 cases undergoing follow-up resection having an accuracy rate of 94%.

Conclusions

This study confirms the feasible of using a Milan-like system in the setting of parotid gland CNB with differentiation in RON and ROM. CNB allows assessment of architectural features that may allow more specific diagnoses in some cases.

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在腮腺核心针活检中应用米兰唾液腺细胞病理学报告系统。

目的：报告涎腺细胞病理学的米兰系统由一个国际专家组开发，并于 2018 年首次发布，旨在规范涎腺抽吸物的报告。提出了具有不同恶性风险的七个类别。涎腺核心针活检（CNB）也很常见，但报告缺乏标准化。在此，我们探讨了腮腺核心针活检（CNB）的米兰式报告系统的可行性：我们在实验室信息系统中搜索了 2010 年至 2021 年的腮腺 CNB 报告。报告被翻译成米兰式报告系统。如有CNB结果，则将其与细胞学和切除标本相关联。为了比较CNB与细针穿刺术（FNA）的效果，我们建立了第二组病例，包括腮腺FNA和手术随访。我们利用随访切除病例计算了 FNA 和 CNB 米兰类别的肿瘤风险 (RON) 和恶性风险 (ROM)。我们分析了 100 例腮腺 CNB 病例。在这些病例中，32 例接受了后续切除术，52 例同时进行了 FNA。共有 20 例病例同时进行了 FNA 并接受了后续切除术。在 63 例（63%）病例中，CNB 提供了明确诊断，其中 18 例接受了后续切除术，准确率为 94%：这项研究证实，在腮腺 CNB 中使用米兰式系统对 RON 和 ROM 进行区分是可行的。腮腺 CNB 可以评估结构特征，从而对某些病例做出更具体的诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Histopathology 医学-病理学

CiteScore

10.20

自引率

4.70%

发文量

239

审稿时长

1 months

期刊介绍： Histopathology is an international journal intended to be of practical value to surgical and diagnostic histopathologists, and to investigators of human disease who employ histopathological methods. Our primary purpose is to publish advances in pathology, in particular those applicable to clinical practice and contributing to the better understanding of human disease.