首页 > 最新文献

Histopathology最新文献

英文 中文
Can patient ancestry influence molecular classifications in myeloid neoplasms? 患者的血统会影响骨髓肿瘤的分子分类吗?
IF 3.9 2区 医学 Q2 CELL BIOLOGY Pub Date : 2024-11-20 DOI: 10.1111/his.15375
Howard Lopes Ribeiro Júnior, Jonas Nogueira Ferreira Maciel Gusmão, João Vitor Caetano Goes
{"title":"Can patient ancestry influence molecular classifications in myeloid neoplasms?","authors":"Howard Lopes Ribeiro Júnior, Jonas Nogueira Ferreira Maciel Gusmão, João Vitor Caetano Goes","doi":"10.1111/his.15375","DOIUrl":"https://doi.org/10.1111/his.15375","url":null,"abstract":"","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution of morphological changes in donor livers undergoing normothermic machine perfusion. 常温机器灌注下供体肝脏形态变化的演变。
IF 3.9 2区 医学 Q2 CELL BIOLOGY Pub Date : 2024-11-20 DOI: 10.1111/his.15371
A L Paterson, R Gaurav, L Swift, R Webster, C Fear, A J Butler, C J E Watson

Aims: There is a shortage of livers for transplantation in the United Kingdom; despite this, more than a fifth of those retrieved are not transplanted. Normothermic machine perfusion (NMP) allows a functional assessment of marginal organs using biochemical parameters. This study describes the histological changes in livers undergoing NMP.

Methods and results: A total of 170 biopsies taken pre-NMP, after 4 h of NMP, end-NMP and at implantation from 50 livers undergoing NMP as part of standard local transplant practice were retrospectively reviewed. Thirty-eight per cent had large droplet macrovesicular steatosis pre-NMP, which was associated with reduced organ utilisation, P = 0.096, subsequent extracellular fat and a neutrophilic reaction; 32% had small droplet macrovesicular steatosis pre-NMP suggestive of acute cellular stress, the severity of which was unchanged in 64% during the perfusion period. Those showing at least moderate hepatocellular necrosis at end-NMP were less likely to be transplanted (55 versus 24%, P = 0.0505). Variation in the extent of hepatocyte necrosis was seen between biopsies, with 43% of transplanted cases showing less hepatocyte necrosis at implantation compared to end-NMP and 21% more severe necrosis. Patchy portal inflammation was present in 96% of pre-NMP biopsies, although identifiable duct injury was rare and portal thrombi were not identified. Sinusoidal dilation pre-NMP was more frequent in donation after circulatory death donors, typically persisted during NMP although had improved by implantation in most and had resolved in cases with an early post-transplant biopsy.

Conclusions: Histological changes in NMP livers predominantly comprise donor-derived steatosis, stress-associated small droplet steatosis, retrieval- and procedure-associated sinusoidal dilation and ischaemic injury.

目的:在英国,用于移植的肝脏短缺;尽管如此,取回的肝脏中仍有五分之一以上未进行移植。常温机器灌注(NMP)可利用生化参数对边缘器官进行功能评估。本研究描述了接受 NMP 的肝脏的组织学变化:作为当地标准移植实践的一部分,对 50 个接受 NMP 的肝脏在 NMP 前、NMP 4 小时后、NMP 结束时和移植时的 170 例活检进行了回顾性审查。38%的肝脏在NMP前出现大液滴大泡性脂肪变性,这与器官利用率降低(P = 0.096)、随后出现细胞外脂肪和中性粒细胞反应有关;32%的肝脏在NMP前出现小液滴大泡性脂肪变性,提示急性细胞应激反应,64%的肝脏在灌注期间应激反应的严重程度不变。在 NMP 结束时至少出现中度肝细胞坏死的患者接受移植的可能性较低(55% 对 24%,P = 0.0505)。不同活检组织的肝细胞坏死程度存在差异,43% 的移植病例在植入时的肝细胞坏死程度低于 NMP 末期,21% 的病例坏死程度更严重。在 96% 的 NMP 前活检中存在斑片状门静脉炎症,但可识别的导管损伤很少见,也未发现门静脉血栓。NMP前的窦状扩张在循环死亡后捐献的捐献者中更为常见,在NMP期间通常会持续存在,但大多数捐献者的情况在移植前已有所改善,在移植后早期活检的病例中已得到缓解:NMP肝脏的组织学变化主要包括供体源性脂肪变性、应激相关的小液滴脂肪变性、取材和手术相关的静脉窦扩张和缺血性损伤。
{"title":"Evolution of morphological changes in donor livers undergoing normothermic machine perfusion.","authors":"A L Paterson, R Gaurav, L Swift, R Webster, C Fear, A J Butler, C J E Watson","doi":"10.1111/his.15371","DOIUrl":"https://doi.org/10.1111/his.15371","url":null,"abstract":"<p><strong>Aims: </strong>There is a shortage of livers for transplantation in the United Kingdom; despite this, more than a fifth of those retrieved are not transplanted. Normothermic machine perfusion (NMP) allows a functional assessment of marginal organs using biochemical parameters. This study describes the histological changes in livers undergoing NMP.</p><p><strong>Methods and results: </strong>A total of 170 biopsies taken pre-NMP, after 4 h of NMP, end-NMP and at implantation from 50 livers undergoing NMP as part of standard local transplant practice were retrospectively reviewed. Thirty-eight per cent had large droplet macrovesicular steatosis pre-NMP, which was associated with reduced organ utilisation, P = 0.096, subsequent extracellular fat and a neutrophilic reaction; 32% had small droplet macrovesicular steatosis pre-NMP suggestive of acute cellular stress, the severity of which was unchanged in 64% during the perfusion period. Those showing at least moderate hepatocellular necrosis at end-NMP were less likely to be transplanted (55 versus 24%, P = 0.0505). Variation in the extent of hepatocyte necrosis was seen between biopsies, with 43% of transplanted cases showing less hepatocyte necrosis at implantation compared to end-NMP and 21% more severe necrosis. Patchy portal inflammation was present in 96% of pre-NMP biopsies, although identifiable duct injury was rare and portal thrombi were not identified. Sinusoidal dilation pre-NMP was more frequent in donation after circulatory death donors, typically persisted during NMP although had improved by implantation in most and had resolved in cases with an early post-transplant biopsy.</p><p><strong>Conclusions: </strong>Histological changes in NMP livers predominantly comprise donor-derived steatosis, stress-associated small droplet steatosis, retrieval- and procedure-associated sinusoidal dilation and ischaemic injury.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent GRHL fusions in a subset of sebaceoma: microscopic and molecular characterisation of eight cases. 皮脂腺瘤亚群中的复发性GRHL融合:八例病例的显微镜和分子特征。
IF 3.9 2区 医学 Q2 CELL BIOLOGY Pub Date : 2024-11-20 DOI: 10.1111/his.15361
Mélanie Legrand, Baptiste Louveau, Nicolas Macagno, Maxence Mancini, Dmitry V Kazakov, Daniel Pissaloux, Franck Tirode, Anne Tallet, Samia Mourah, Quentin Lepiller, Arnaud de la Fouchardière, Pierre Sohier, Eric Frouin, Andreas von Deimling, Keisuke Goto, Bernard Cribier, Eduardo Calonje, Saleem Taibjee, Maxime Battistella, Thibault Kervarrec

Aims: Sebaceous neoplasms constitute a group of adnexal tumours, including sebaceous adenoma, sebaceoma and sebaceous carcinoma. Although mismatch repair deficiency may be observed, the nature of the genetic alterations contributing to the development of most of these tumours is still unknown. In the present study, we describe the clinical, microscopic, and molecular features of eight sebaceomas with GRHL gene rearrangement.

Methods and results: Among these sebaceomas, four occurred in women and four in men; the median age was 63 years (range = 29-89). The tumours were located in the head and neck area in all cases. Microscopic examination revealed a well-demarcated lesion located in the dermis with focal extension into the subcutaneous tissue (three cases). The neoplasms displayed macronodular (eight cases), cribriform (seven cases) and organoid (six cases) growth patterns, occurring in combination. The tumours were mainly composed of immature basophilic cells associated with scattered mature sebocytes. Numerous small infundibular cysts were present in seven cases. Mitotic activity was low (none/one to four mitoses/mm2). Immunohistochemistry showed positivity for androgen receptor and p63. Preserved expression of MLH1, PMS2, MSH2 and MSH6 was observed in all cases. RNA-sequencing revealed RCOR1::GRHL2 (three cases), BCL6::GRHL1 (two cases), a BCOR::GRHL2 (one case), RCOR1::GRHL1 (one case) and TLE1::GRHL1 (one case) fusion transcript. Methylation analysis demonstrated that GRHL-fused sebaceomas form an independent cluster and highlight the proximity of such tumours with poromas with folliculo-sebaceous differentiation.

Conclusions: In conclusion, we report recurrent fusions of the GRHL genes in a distinctive subset of sebaceomas harbouring infundibulocystic differentiation, a frequent organoid growth pattern and lack of mismatch repair deficiency.

目的:皮脂腺肿瘤是一组附件肿瘤,包括皮脂腺瘤、皮脂瘤和皮脂癌。虽然可以观察到错配修复缺陷,但导致大多数此类肿瘤发生的基因改变的性质仍不清楚。在本研究中,我们描述了 8 例伴有 GRHL 基因重排的皮脂瘤的临床、显微和分子特征:在这些皮脂瘤中,4例女性,4例男性;中位年龄为63岁(范围=29-89岁)。所有病例的肿瘤均位于头颈部。显微镜检查显示,病变位于真皮层,界限清楚,病灶延伸至皮下组织(3 例)。肿瘤的生长方式有大结节型(8 例)、楔形型(7 例)和类器官型(6 例),且合并发生。肿瘤主要由未成熟的嗜碱性细胞和散在的成熟皮脂腺细胞组成。7个病例中存在大量的小腺泡囊肿。有丝分裂活性较低(无/1至4个有丝分裂/mm2)。免疫组化显示雄激素受体和 p63 呈阳性。在所有病例中均观察到 MLH1、PMS2、MSH2 和 MSH6 的保留表达。RNA测序发现了RCOR1::GRHL2(3例)、BCL6::GRHL1(2例)、BCOR::GRHL2(1例)、RCOR1::GRHL1(1例)和TLE1::GRHL1(1例)融合转录本。甲基化分析表明,GRHL融合的皮脂瘤形成了一个独立的群组,并突出了此类肿瘤与具有毛囊皮脂腺分化的孔瘤的相似性:总之,我们报告了一个独特的皮脂瘤亚群中GRHL基因的复发性融合,该亚群具有基金组织囊性分化、频繁的类器官生长模式和缺乏错配修复缺陷。
{"title":"Recurrent GRHL fusions in a subset of sebaceoma: microscopic and molecular characterisation of eight cases.","authors":"Mélanie Legrand, Baptiste Louveau, Nicolas Macagno, Maxence Mancini, Dmitry V Kazakov, Daniel Pissaloux, Franck Tirode, Anne Tallet, Samia Mourah, Quentin Lepiller, Arnaud de la Fouchardière, Pierre Sohier, Eric Frouin, Andreas von Deimling, Keisuke Goto, Bernard Cribier, Eduardo Calonje, Saleem Taibjee, Maxime Battistella, Thibault Kervarrec","doi":"10.1111/his.15361","DOIUrl":"https://doi.org/10.1111/his.15361","url":null,"abstract":"<p><strong>Aims: </strong>Sebaceous neoplasms constitute a group of adnexal tumours, including sebaceous adenoma, sebaceoma and sebaceous carcinoma. Although mismatch repair deficiency may be observed, the nature of the genetic alterations contributing to the development of most of these tumours is still unknown. In the present study, we describe the clinical, microscopic, and molecular features of eight sebaceomas with GRHL gene rearrangement.</p><p><strong>Methods and results: </strong>Among these sebaceomas, four occurred in women and four in men; the median age was 63 years (range = 29-89). The tumours were located in the head and neck area in all cases. Microscopic examination revealed a well-demarcated lesion located in the dermis with focal extension into the subcutaneous tissue (three cases). The neoplasms displayed macronodular (eight cases), cribriform (seven cases) and organoid (six cases) growth patterns, occurring in combination. The tumours were mainly composed of immature basophilic cells associated with scattered mature sebocytes. Numerous small infundibular cysts were present in seven cases. Mitotic activity was low (none/one to four mitoses/mm<sup>2</sup>). Immunohistochemistry showed positivity for androgen receptor and p63. Preserved expression of MLH1, PMS2, MSH2 and MSH6 was observed in all cases. RNA-sequencing revealed RCOR1::GRHL2 (three cases), BCL6::GRHL1 (two cases), a BCOR::GRHL2 (one case), RCOR1::GRHL1 (one case) and TLE1::GRHL1 (one case) fusion transcript. Methylation analysis demonstrated that GRHL-fused sebaceomas form an independent cluster and highlight the proximity of such tumours with poromas with folliculo-sebaceous differentiation.</p><p><strong>Conclusions: </strong>In conclusion, we report recurrent fusions of the GRHL genes in a distinctive subset of sebaceomas harbouring infundibulocystic differentiation, a frequent organoid growth pattern and lack of mismatch repair deficiency.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic features in paediatric MDS-EB with UBTF-internal tandem duplication: defining a unique subgroup. 具有 UBTF 内部串联重复的儿科 MDS-EB 的诊断特征:定义一个独特的亚组。
IF 3.9 2区 医学 Q2 CELL BIOLOGY Pub Date : 2024-11-20 DOI: 10.1111/his.15378
Stephan Schwarz-Furlan, Carole Gengler, Ayami Yoshimi-Noellke, Guido Piontek, Yuki Schneider-Kimoto, Markus Schmugge, Christian Thiede, Charlotte M Niemeyer, Miriam Erlacher, Martina Rudelius

Aim: Tandem-duplications of the UBTF gene (UBTF-TDs) have recently been identified as a new genetic driver in young individuals with acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS). Disease in these newly defined subgroups is characterized by poor response to standard intensive chemotherapy and inferior survival of the affected patients. However, a thorough analysis of bone marrow histomorphology of UBTF-mutated neoplasia has not been undertaken thus far.

Methods and results: In this retrospective study, we investigated the characteristic histopathological features of a cohort comprising 14 paediatric MDS patients with an excess of blasts (MDS-EB) and UBTF-TD. Bone marrow biopsies from these patients revealed hypercellularity and severe dysplasia across all three haematopoietic lineages. In particular, a marked hyperplastic megakaryopoiesis characterized by the presence of frequent micromegakaryocytes and a high number of monolobulated cells forming small clusters was observed. Additionally, erythropoiesis was left-shifted, with numerous blastoid precursors. The granulopoietic precursors displayed prominent UBTF-positive nucleoli.

Conclusion: The unique combination of these histomorphological features strongly suggests a possible UBTF aberration. It will allow initiating the appropriate genetic testing to confirm the presence of UBTF-TD and identify potential additional genetic alterations. Such molecular profiling will not only contribute to a better understanding of the disease mechanism, but also facilitate more rational treatment approaches for these high-risk paediatric MDS patients.

目的:最近发现,UTF 基因的串联重复(UTF-TDs)是急性髓性白血病(AML)和骨髓增生异常综合征(MDS)年轻患者的一种新的遗传驱动因素。这些新定义亚组的疾病特点是对标准强化化疗反应差,患者生存率低。然而,迄今为止,尚未对 UBTF 基因突变肿瘤的骨髓组织形态学进行全面分析:在这项回顾性研究中,我们调查了由14例儿童MDS患者(MDS-EB)和UTB-TD组成的队列的组织病理学特征。这些患者的骨髓活检结果显示,所有三个造血系均出现细胞增生和严重发育不良。特别是观察到明显的巨核细胞增生,其特点是经常出现小巨核细胞和大量形成小簇的单核细胞。此外,红细胞生成左移,出现大量胚泡前体。粒细胞前体显示出突出的 UBTF 阳性核小体:结论:这些组织形态学特征的独特组合强烈提示可能存在UTF畸变。结论:这些组织形态学特征的独特组合强烈提示可能存在UTF畸变,这将有助于启动适当的基因检测,以确认是否存在UTF-TD,并识别潜在的其他基因改变。这种分子谱分析不仅有助于更好地了解疾病机制,还有助于为这些高风险儿科 MDS 患者提供更合理的治疗方法。
{"title":"Diagnostic features in paediatric MDS-EB with UBTF-internal tandem duplication: defining a unique subgroup.","authors":"Stephan Schwarz-Furlan, Carole Gengler, Ayami Yoshimi-Noellke, Guido Piontek, Yuki Schneider-Kimoto, Markus Schmugge, Christian Thiede, Charlotte M Niemeyer, Miriam Erlacher, Martina Rudelius","doi":"10.1111/his.15378","DOIUrl":"https://doi.org/10.1111/his.15378","url":null,"abstract":"<p><strong>Aim: </strong>Tandem-duplications of the UBTF gene (UBTF-TDs) have recently been identified as a new genetic driver in young individuals with acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS). Disease in these newly defined subgroups is characterized by poor response to standard intensive chemotherapy and inferior survival of the affected patients. However, a thorough analysis of bone marrow histomorphology of UBTF-mutated neoplasia has not been undertaken thus far.</p><p><strong>Methods and results: </strong>In this retrospective study, we investigated the characteristic histopathological features of a cohort comprising 14 paediatric MDS patients with an excess of blasts (MDS-EB) and UBTF-TD. Bone marrow biopsies from these patients revealed hypercellularity and severe dysplasia across all three haematopoietic lineages. In particular, a marked hyperplastic megakaryopoiesis characterized by the presence of frequent micromegakaryocytes and a high number of monolobulated cells forming small clusters was observed. Additionally, erythropoiesis was left-shifted, with numerous blastoid precursors. The granulopoietic precursors displayed prominent UBTF-positive nucleoli.</p><p><strong>Conclusion: </strong>The unique combination of these histomorphological features strongly suggests a possible UBTF aberration. It will allow initiating the appropriate genetic testing to confirm the presence of UBTF-TD and identify potential additional genetic alterations. Such molecular profiling will not only contribute to a better understanding of the disease mechanism, but also facilitate more rational treatment approaches for these high-risk paediatric MDS patients.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dedicated diagnostic approaches for mature B-cell non-Hodgkin lymphomas occurring in children, adolescents, and young adults. 针对发生在儿童、青少年和年轻人身上的成熟 B 细胞非霍奇金淋巴瘤的专用诊断方法。
IF 3.9 2区 医学 Q2 CELL BIOLOGY Pub Date : 2024-11-20 DOI: 10.1111/his.15362
Ana C Xavier, Andishe Attarbaschi, Dita Gratzinger, Olga Balagué

Non-Hodgkin lymphoma (NHL) represents the fourth most common malignant disease among children and adolescents. Current disease classifications, including the most recent World Health Organization (WHO) classification and the International Consensus Classification (ICC), rely on a combination of clinical, epidemiological, histologic, immunophenotypic, and molecular data to define discrete clinicopathologic entities. There is growing evidence that children, adolescents, and young adults (CAYA) with B-cell NHL display unique clinical and epidemiologic characteristics. This may be explained by distinct age-related developmental plasticity, immune and haematopoietic repertoires, environmental exposures and social determinants of health, and germline or acquired genetic and molecular features, including those associated with inborn errors of immunity (IEI). Here, we discuss the unique clinical and biological characteristics of several distinct paediatric B-cell NHL types to indicate a path forward in classification of these CAYA NHL to optimally support multidisciplinary patient care and personalized treatment. We propose a potential "arising in CAYA" classification qualifier to denote the distinct clinicopathologic characteristics of B-cell NHLs that, otherwise, histologically and immunophenotypically resemble those arising in middle-aged and older adults. We also discuss how haemopathology diagnoses are evolving to incorporate the most current scientific knowledge into future classification systems of CAYA B-cell NHL.

非霍奇金淋巴瘤(NHL)是儿童和青少年中第四大常见恶性疾病。目前的疾病分类,包括最新的世界卫生组织(WHO)分类和国际共识分类(ICC),都依赖于临床、流行病学、组织学、免疫表型和分子数据的组合来定义不同的临床病理实体。越来越多的证据表明,患有 B 细胞 NHL 的儿童、青少年和年轻成人(CAYA)显示出独特的临床和流行病学特征。这可能是由于与年龄相关的发育可塑性、免疫和造血系统、环境暴露和健康的社会决定因素以及种系或获得性遗传和分子特征(包括与先天性免疫错误(IEI)相关的特征)所造成的。在此,我们将讨论几种不同类型的儿科 B 细胞 NHL 的独特临床和生物学特征,为这些 CAYA NHL 的分类指明方向,以便为多学科患者护理和个性化治疗提供最佳支持。我们提出了一个潜在的 "产生于 CAYA "分类限定词,以表示 B 细胞 NHL 的独特临床病理特征,除此之外,这些 B 细胞 NHL 在组织学和免疫表型上与产生于中老年人的 B 细胞 NHL 相似。我们还讨论了血液病理学诊断如何发展,以便将最新的科学知识纳入未来的 CAYA B 细胞 NHL 分类系统。
{"title":"Dedicated diagnostic approaches for mature B-cell non-Hodgkin lymphomas occurring in children, adolescents, and young adults.","authors":"Ana C Xavier, Andishe Attarbaschi, Dita Gratzinger, Olga Balagué","doi":"10.1111/his.15362","DOIUrl":"https://doi.org/10.1111/his.15362","url":null,"abstract":"<p><p>Non-Hodgkin lymphoma (NHL) represents the fourth most common malignant disease among children and adolescents. Current disease classifications, including the most recent World Health Organization (WHO) classification and the International Consensus Classification (ICC), rely on a combination of clinical, epidemiological, histologic, immunophenotypic, and molecular data to define discrete clinicopathologic entities. There is growing evidence that children, adolescents, and young adults (CAYA) with B-cell NHL display unique clinical and epidemiologic characteristics. This may be explained by distinct age-related developmental plasticity, immune and haematopoietic repertoires, environmental exposures and social determinants of health, and germline or acquired genetic and molecular features, including those associated with inborn errors of immunity (IEI). Here, we discuss the unique clinical and biological characteristics of several distinct paediatric B-cell NHL types to indicate a path forward in classification of these CAYA NHL to optimally support multidisciplinary patient care and personalized treatment. We propose a potential \"arising in CAYA\" classification qualifier to denote the distinct clinicopathologic characteristics of B-cell NHLs that, otherwise, histologically and immunophenotypically resemble those arising in middle-aged and older adults. We also discuss how haemopathology diagnoses are evolving to incorporate the most current scientific knowledge into future classification systems of CAYA B-cell NHL.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sinonasal adenosquamous carcinomas arising in seromucinous hamartoma or respiratory epithelial adenomatoid hamartoma with atypical features: Report of five detailed clinicopathological and molecular characterisation of rare entity. 鼻窦腺鳞癌产生于血清粘液性火腿状瘤或具有非典型特征的呼吸道上皮腺瘤样火腿状瘤:报告五例罕见病例的详细临床病理学和分子特征。
IF 3.9 2区 医学 Q2 CELL BIOLOGY Pub Date : 2024-11-20 DOI: 10.1111/his.15369
Martina Bradová, Valerie Costes-Martineau, Jan Laco, Tomáš Vaněček, Petr Grossmann, Jana Němcová, Zdeněk Pavlovský, Alena Skálová, Michal Michal

Aims: Sinonasal adenosquamous carcinoma (ASC) is a rare tumour classified as a variant of squamous cell carcinoma, exhibiting both squamous and glandular differentiation. ASC has a poorer prognosis compared to sinonasal mucoepidermoid carcinoma (MEC), another uncommon tumour in this region. ASC is believed to originate from metaplastic squamous epithelium, though it may also arise from respiratory epithelium in respiratory epithelial adenomatoid hamartoma (REAH) or seromucinous glands in seromucinous hamartoma (SH).

Methods and results: Five cases of sinonasal ASC were retrieved from our registry. Initially, they were classified as sinonasal MEC (n = 3), ASC (n = 2), and carcinoma ex REAH (n = 1). All cases showed adenosquamous malignant proliferation beneath the surface respiratory epithelium with occasional squamous metaplasia, except for one case that showed dysplasia. The respiratory epithelium exhibited an inverted growth pattern consistent with REAH/SH, and displayed atypical sinonasal glands (ASGSH) arising within seromucinous hamartoma. Next-generation sequencing (NGS) revealed multiple pathogenic mutations in two cases, and in case 4 GGA2::PRKCB and EYA2::SERINC3 gene fusions. One case was positive for high-risk HPV. None of the cases exhibited CRTC1/3::MAML2 gene fusion.

Conclusion: The connection between ASGSH and ASC has not been described in the literature. There is a growing need for additional studies on the morphological, immunohistochemical, and genetic aspects of these tumours. SH/REAH may serve as precursor lesions in the progression of atypical sinonasal glands to malignancy, and their role in tumour development deserves further investigation.

目的:鼻窦腺鳞癌(ASC)是一种罕见肿瘤,属于鳞状细胞癌的变异型,同时表现出鳞状和腺状分化。与鼻窦粘液表皮样癌(MEC)相比,腺鳞癌的预后较差。ASC被认为起源于移行鳞状上皮,但也可能起源于呼吸上皮腺瘤样火腿肠瘤(REAH)中的呼吸上皮或血清粘液性火腿肠瘤(SH)中的血清粘液腺:从我们的登记册中检索到5例鼻窦ASC病例。初步分类为鼻窦MEC(3例)、ASC(2例)和REAH癌(1例)。除一例出现发育不良外,其他病例均表现为呼吸道上皮表面下的腺鳞状恶性增生,偶有鳞状化生。呼吸道上皮表现出与REAH/SH一致的倒置生长模式,并显示出血清粘液瘤内产生的非典型鼻窦腺体(ASGSH)。下一代测序(NGS)发现两例患者存在多种致病基因突变,第4例患者存在GGA2::PRKCB和EYA2::SERINC3基因融合。一个病例的高危 HPV 阳性。所有病例均无 CRTC1/3::MAML2 基因融合:结论:ASGSH与ASC之间的联系尚未在文献中有所描述。我们越来越需要对这些肿瘤的形态学、免疫组化和遗传学方面进行更多的研究。SH/REAH可能是非典型性鼻窦腺恶变的前驱病变,它们在肿瘤发生中的作用值得进一步研究。
{"title":"Sinonasal adenosquamous carcinomas arising in seromucinous hamartoma or respiratory epithelial adenomatoid hamartoma with atypical features: Report of five detailed clinicopathological and molecular characterisation of rare entity.","authors":"Martina Bradová, Valerie Costes-Martineau, Jan Laco, Tomáš Vaněček, Petr Grossmann, Jana Němcová, Zdeněk Pavlovský, Alena Skálová, Michal Michal","doi":"10.1111/his.15369","DOIUrl":"https://doi.org/10.1111/his.15369","url":null,"abstract":"<p><strong>Aims: </strong>Sinonasal adenosquamous carcinoma (ASC) is a rare tumour classified as a variant of squamous cell carcinoma, exhibiting both squamous and glandular differentiation. ASC has a poorer prognosis compared to sinonasal mucoepidermoid carcinoma (MEC), another uncommon tumour in this region. ASC is believed to originate from metaplastic squamous epithelium, though it may also arise from respiratory epithelium in respiratory epithelial adenomatoid hamartoma (REAH) or seromucinous glands in seromucinous hamartoma (SH).</p><p><strong>Methods and results: </strong>Five cases of sinonasal ASC were retrieved from our registry. Initially, they were classified as sinonasal MEC (n = 3), ASC (n = 2), and carcinoma ex REAH (n = 1). All cases showed adenosquamous malignant proliferation beneath the surface respiratory epithelium with occasional squamous metaplasia, except for one case that showed dysplasia. The respiratory epithelium exhibited an inverted growth pattern consistent with REAH/SH, and displayed atypical sinonasal glands (ASGSH) arising within seromucinous hamartoma. Next-generation sequencing (NGS) revealed multiple pathogenic mutations in two cases, and in case 4 GGA2::PRKCB and EYA2::SERINC3 gene fusions. One case was positive for high-risk HPV. None of the cases exhibited CRTC1/3::MAML2 gene fusion.</p><p><strong>Conclusion: </strong>The connection between ASGSH and ASC has not been described in the literature. There is a growing need for additional studies on the morphological, immunohistochemical, and genetic aspects of these tumours. SH/REAH may serve as precursor lesions in the progression of atypical sinonasal glands to malignancy, and their role in tumour development deserves further investigation.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shared immunohistochemical and genomic features of the low- and high-grade components of a cutaneous secretory carcinoma with epidermotrophism and lymph node involvement. 伴有表皮营养不良和淋巴结受累的皮肤分泌癌的低级别和高级别组成部分的共同免疫组化和基因组特征。
IF 3.9 2区 医学 Q2 CELL BIOLOGY Pub Date : 2024-11-18 DOI: 10.1111/his.15351
Zlatko Marusic, Louise van der Weyden, Dimas Suárez Vilela, Faustino Suárez Sánchez, Jose Ramón Méndez Álvarez, Martin Del Castillo Velasco-Herrera, Ingrid Ferreira, David J Adams, Eduardo Calonje
{"title":"Shared immunohistochemical and genomic features of the low- and high-grade components of a cutaneous secretory carcinoma with epidermotrophism and lymph node involvement.","authors":"Zlatko Marusic, Louise van der Weyden, Dimas Suárez Vilela, Faustino Suárez Sánchez, Jose Ramón Méndez Álvarez, Martin Del Castillo Velasco-Herrera, Ingrid Ferreira, David J Adams, Eduardo Calonje","doi":"10.1111/his.15351","DOIUrl":"10.1111/his.15351","url":null,"abstract":"","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolving molecular classification of aggressive B-cell lymphoma. 侵袭性 B 细胞淋巴瘤分子分类的演变。
IF 3.9 2区 医学 Q2 CELL BIOLOGY Pub Date : 2024-11-15 DOI: 10.1111/his.15350
Stefan K Alig, Björn Chapuy, Daisuke Ennishi, Kieron Dunleavy, Daniel J Hodson

This review aims to provide an overview of the latest developments in the classification and molecular understanding of aggressive B-cell lymphomas, specifically focusing on diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma (HGBL). Advances in molecular techniques have led to novel ways to classify these lymphomas based on clinical, histological, transcriptional, and genetic properties. While these methods have predominantly focused on the malignant compartment, recent studies emphasize the value of profiling the tumour microenvironment for a more comprehensive disease classification. Additionally, the integration of liquid biopsies represents a promising advancement, offering less invasive and dynamic insights into tumour characteristics and treatment response. Although molecular profiles are not yet routinely used to guide therapy, emerging data highlight their potential to predict responses to novel treatments. It is our belief that integrating molecular profiling and liquid biopsies into clinical practice and research now will pave the way for more personalized and effective therapies in the future.

本综述旨在概述侵袭性B细胞淋巴瘤分类和分子认识方面的最新进展,尤其侧重于弥漫大B细胞淋巴瘤(DLBCL)和高级别B细胞淋巴瘤(HGBL)。分子技术的进步带来了根据临床、组织学、转录和遗传特性对这些淋巴瘤进行分类的新方法。虽然这些方法主要集中在恶性区,但最近的研究强调了肿瘤微环境剖析对更全面的疾病分类的价值。此外,液体活检的整合也是一项很有前景的进步,它能以较低的侵入性和动态的方式深入了解肿瘤特征和治疗反应。虽然分子图谱尚未被常规用于指导治疗,但新出现的数据突显了其预测对新型疗法反应的潜力。我们相信,现在将分子图谱和液体活检融入临床实践和研究,将为未来更个性化、更有效的疗法铺平道路。
{"title":"Evolving molecular classification of aggressive B-cell lymphoma.","authors":"Stefan K Alig, Björn Chapuy, Daisuke Ennishi, Kieron Dunleavy, Daniel J Hodson","doi":"10.1111/his.15350","DOIUrl":"10.1111/his.15350","url":null,"abstract":"<p><p>This review aims to provide an overview of the latest developments in the classification and molecular understanding of aggressive B-cell lymphomas, specifically focusing on diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma (HGBL). Advances in molecular techniques have led to novel ways to classify these lymphomas based on clinical, histological, transcriptional, and genetic properties. While these methods have predominantly focused on the malignant compartment, recent studies emphasize the value of profiling the tumour microenvironment for a more comprehensive disease classification. Additionally, the integration of liquid biopsies represents a promising advancement, offering less invasive and dynamic insights into tumour characteristics and treatment response. Although molecular profiles are not yet routinely used to guide therapy, emerging data highlight their potential to predict responses to novel treatments. It is our belief that integrating molecular profiling and liquid biopsies into clinical practice and research now will pave the way for more personalized and effective therapies in the future.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between CTNNB1 mutation status and tumour phenotype in hepatitis B virus-related hepatocellular carcinoma. 乙型肝炎病毒相关肝细胞癌中 CTNNB1 突变状态与肿瘤表型之间的相关性。
IF 3.9 2区 医学 Q2 CELL BIOLOGY Pub Date : 2024-11-11 DOI: 10.1111/his.15363
Yoon Jung Hwang, Yangkyu Lee, Su Jong Yu, Suk Kyun Hong, Nam-Joon Yi, YoungRok Choi, Hyejung Lee, Wonju Chung, Haeryoung Kim

Aims: The frequency of CTNNB1 mutation, one of the most frequent genetic events in hepatocellular carcinoma (HCC), is lower in Asian countries and in hepatitis B virus (HBV)-related HCCs. In this study, we evaluated the prevalence and types of CTNNB1-mutation in HBV-related HCC and correlated the molecular status with the histomorphological and immunohistochemical features.

Methods and results: A total of 108 consecutive cases of treatment-naïve, surgically resected HBV-related HCCs were selected. Targeted sequencing for CTNNB1 exons 3, 7 and 8 was performed, and the results were correlated with the expression pattern of glutamine synthetase (GS), nuclear β-catenin expression status and the histomorphological characteristics of the tumour. CTNNB1 mutations were identified in 13% of HBV-related HCCs; of these cases, mutations were found in D32-S37 (7%), T41 (4%) and S45 (2%) of exon 3. None of the HCCs demonstrated alterations in exons 7 and 8. CTNNB1 mutation was strongly associated with diffuse strong GS expression (P < 0.001), nuclear β-catenin expression (P < 0.001) and the classic CTNNB1 morphology (P = 0.038). Diffuse strong GS expression was observed in 78.6% of the CTNNB1-mutated HCCs, and nuclear β-catenin expression was identified in 64.3% of these cases. The classic CTNNB1 morphology was observed in 57% of all CTNNB1-mutated HCCs. Furthermore, programmed death-ligand 1 (PD-L1) was less frequently expressed in HCCs with classic CTNNB1 morphology.

Conclusions: CTNNB1 mutation was observed in 13% of HBV-related HCCs in this Korean cohort, and was associated with diffuse strong GS expression, nuclear β-catenin expression and classic CTNNB1 morphology.

目的:CTNNB1突变是肝细胞癌(HCC)中最常见的基因事件之一,在亚洲国家和乙型肝炎病毒(HBV)相关HCC中的发生率较低。在这项研究中,我们评估了 CTNNB1 突变在 HBV 相关 HCC 中的发生率和类型,并将分子状态与组织形态学和免疫组化特征进行了相关分析:共选择了108例连续的治疗无效、手术切除的HBV相关HCC。对 CTNNB1 第 3、7 和 8 号外显子进行了靶向测序,测序结果与谷氨酰胺合成酶(GS)的表达模式、核β-catenin 的表达状态以及肿瘤的组织形态学特征相关。在13%的HBV相关HCC中发现了CTNNB1突变;其中,在第3外显子的D32-S37(7%)、T41(4%)和S45(2%)处发现了突变。没有任何 HCC 显示第 7 和第 8 外显子发生了改变。CTNNB1 突变与弥漫性强 GS 表达密切相关(P 结论:CTNNB1 突变与弥漫性强 GS 表达密切相关:在该韩国队列中,13% 的 HBV 相关 HCC 发现 CTNNB1 突变,且与弥漫性强 GS 表达、核 β-catenin 表达和典型 CTNNB1 形态相关。
{"title":"Correlation between CTNNB1 mutation status and tumour phenotype in hepatitis B virus-related hepatocellular carcinoma.","authors":"Yoon Jung Hwang, Yangkyu Lee, Su Jong Yu, Suk Kyun Hong, Nam-Joon Yi, YoungRok Choi, Hyejung Lee, Wonju Chung, Haeryoung Kim","doi":"10.1111/his.15363","DOIUrl":"https://doi.org/10.1111/his.15363","url":null,"abstract":"<p><strong>Aims: </strong>The frequency of CTNNB1 mutation, one of the most frequent genetic events in hepatocellular carcinoma (HCC), is lower in Asian countries and in hepatitis B virus (HBV)-related HCCs. In this study, we evaluated the prevalence and types of CTNNB1-mutation in HBV-related HCC and correlated the molecular status with the histomorphological and immunohistochemical features.</p><p><strong>Methods and results: </strong>A total of 108 consecutive cases of treatment-naïve, surgically resected HBV-related HCCs were selected. Targeted sequencing for CTNNB1 exons 3, 7 and 8 was performed, and the results were correlated with the expression pattern of glutamine synthetase (GS), nuclear β-catenin expression status and the histomorphological characteristics of the tumour. CTNNB1 mutations were identified in 13% of HBV-related HCCs; of these cases, mutations were found in D32-S37 (7%), T41 (4%) and S45 (2%) of exon 3. None of the HCCs demonstrated alterations in exons 7 and 8. CTNNB1 mutation was strongly associated with diffuse strong GS expression (P < 0.001), nuclear β-catenin expression (P < 0.001) and the classic CTNNB1 morphology (P = 0.038). Diffuse strong GS expression was observed in 78.6% of the CTNNB1-mutated HCCs, and nuclear β-catenin expression was identified in 64.3% of these cases. The classic CTNNB1 morphology was observed in 57% of all CTNNB1-mutated HCCs. Furthermore, programmed death-ligand 1 (PD-L1) was less frequently expressed in HCCs with classic CTNNB1 morphology.</p><p><strong>Conclusions: </strong>CTNNB1 mutation was observed in 13% of HBV-related HCCs in this Korean cohort, and was associated with diffuse strong GS expression, nuclear β-catenin expression and classic CTNNB1 morphology.</p>","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-neoplastic potentials including metachronous clonally unrelated nodal T-follicular helper cell lymphomas in clonal haematopoiesis. 克隆性造血中的多瘤性潜能,包括克隆无关的结节性 T 滤泡辅助细胞淋巴瘤。
IF 3.9 2区 医学 Q2 CELL BIOLOGY Pub Date : 2024-11-11 DOI: 10.1111/his.15367
Ayoma D Attygalle, Pui Kwan Chak, Ewelina Madej, Maria-Myrsini Tzioni, Zi Chen, Ming-Qing Du
{"title":"Multi-neoplastic potentials including metachronous clonally unrelated nodal T-follicular helper cell lymphomas in clonal haematopoiesis.","authors":"Ayoma D Attygalle, Pui Kwan Chak, Ewelina Madej, Maria-Myrsini Tzioni, Zi Chen, Ming-Qing Du","doi":"10.1111/his.15367","DOIUrl":"https://doi.org/10.1111/his.15367","url":null,"abstract":"","PeriodicalId":13219,"journal":{"name":"Histopathology","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Histopathology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1