Association of Urinary Biomarkers of Tobacco Exposure with Lung Cancer Risk in African American and White Cigarette Smokers in the Southern Community Cohort Study.

IF 3.4 3区医学 Q2 ONCOLOGY Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-08-01 DOI:10.1158/1055-9965.EPI-23-1362

Sharon E Murphy, Cherie Guillermo, Nicole M Thomson, Steven G Carmella, Milo Wittmann, Melinda C Aldrich, Qiuyin Cai, Shannon M Sullivan, Daniel O Stram, Loïc Le Marchand, Stephen S Hecht, William J Blot, S Lani Park

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Abstract

Background: After accounting for smoking history, lung cancer incidence is greater in African Americans than Whites. In the multiethnic cohort, total nicotine equivalents (TNE) are higher in African Americans than Whites at similar reported cigarettes per day. Greater toxicant uptake per cigarette may contribute to the greater lung cancer risk of African Americans.

Methods: In a nested case-control lung cancer study within the Southern Community Cohort, smoking-related biomarkers were measured in 259 cases and 503 controls (40% White; 56% African American). TNE, the trans-3-hydroxycotinine/cotinine ratio, 4-(methylnitrosamino)-1-3-(pyridyl)-1-butanol (NNAL), mercapturic acid metabolites of volatile organic compounds, phenanthrene metabolites, cadmium (Cd), and (Z)-7-(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopenyl]hept-5-enoic acid were quantified in urine. Unconditional logistic regression was used to estimate the ORs and 95% confidence intervals (CI) for each biomarker and lung cancer risk.

Results: TNE, NNAL, and Cd were higher in cases than controls (adjusted for age, race, sex, body mass index, and cigarettes per day). Among cases, these levels were higher in African Americans compared with Whites. After accounting for age, sex, body mass index, and pack-years, a one-SD increase in log-TNE (OR = 1.30; 95% CI, 1.10-1.54) and log-NNAL (OR = 1.27; 95% CI, 1.03-1.58 with TNE adjustment) was associated with lung cancer risk. In this study, in which NNAL concentration is relatively high, the association for log-TNE was attenuated after adjustment for log-NNAL.

Conclusions: Smoking-related biomarkers provide additional information for lung cancer risk in smokers beyond smoking pack-years.

Impact: Urinary NNAL, TNE, and Cd concentrations in current smokers, particularly African American smokers, may be useful for predicting lung cancer risk.

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南方社区队列研究》中非裔美国人和白人吸烟者尿液中烟草暴露生物标志物与肺癌风险的关系。

背景：在考虑吸烟史后，非裔美国人的肺癌发病率高于白人。在多种族队列（Multiethnic Cohort）中，非裔美国人的尼古丁总当量（TNE）高于白人，而报告的每日吸烟量（CPD）与白人相似。每支香烟摄入的有毒物质更多，这可能是非裔美国人患肺癌风险更大的原因：在南方社区队列（Southern Community Cohort）的一项巢式病例对照肺癌研究中，对 259 例病例和 503 例对照（白人占 40%，非裔美国人占 56%）进行了吸烟相关生物标记物的测量。TNE，反式-3-羟基可替宁：可替宁比率、4-（甲基亚硝基氨基）-1-3-（吡啶基）-1-丁醇（NNAL）、挥发性有机化合物的巯基酸代谢物、菲代谢物、尿液中的镉和(Z)-7-(1R,2R,3R,5S)-3,5-二羟基-2-[(E,3S)-3-羟基辛-1-烯基]环戊烯基]庚-5-烯酸（8-异-PGF2α）被定量。采用无条件逻辑回归法估算了每种生物标志物与肺癌风险的几率比和 95% 的置信区间：病例的TNE、NNAL和镉含量均高于对照组（已对年龄、种族、性别、体重指数（BMI）和CPD进行调整）。在病例中，非裔美国人的上述水平高于白人。在考虑了年龄、性别、体重指数和包年后，log-TNE（OR=1.30；95% CI：1.10-1.54）和log-NNAL（OR=1.27；95% CI：1.03-1.58，经TNE调整）每增加一个标准差都与肺癌风险有关。在这项研究中，NNAL的浓度相对较高，在对log-NNAL进行调整后，log-TNE的相关性有所减弱：结论：吸烟相关生物标志物为吸烟者的肺癌风险提供了吸烟包年以外的额外信息：影响：当前吸烟者（尤其是非裔美国人吸烟者）尿液中的 NNAL、TNE 和镉浓度可能有助于预测肺癌风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

2.60%

发文量

538

审稿时长

1.6 months

期刊介绍： Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.