In search of a function for human type III interferons: insights from inherited and acquired deficits

IF 6.6 2区医学 Q1 IMMUNOLOGY Current Opinion in Immunology Pub Date : 2024-04-01 DOI:10.1016/j.coi.2024.102427

Qian Zhang , Kai Kisand , Yi Feng , Darawan Rinchai , Emmanuelle Jouanguy , Aurélie Cobat , Jean-Laurent Casanova , Shen-Ying Zhang

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Abstract

The essential and redundant functions of human type I and II interferons (IFNs) have been delineated over the last three decades by studies of patients with inborn errors of immunity or their autoimmune phenocopies, but much less is known about type III IFNs. Patients with cells that do not respond to type III IFNs due to inherited IL10RB deficiency display no overt viral disease, and their inflammatory disease phenotypes can be explained by defective signaling via other interleukine10RB-dependent pathways. Moreover, patients with inherited deficiencies of interferon-stimulated gene factor 3 (ISGF-3) (STAT1, STAT2, IRF9) present viral diseases also seen in patients with inherited deficiencies of the type I IFN receptor (IFNAR1/2). Finally, patients with autoantibodies neutralizing type III IFNs have no obvious predisposition to viral disease. Current findings thus suggest that type III IFNs are largely redundant in humans. The essential functions of human type III IFNs, particularly in antiviral defenses, remain to be discovered.

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寻找人类 III 型干扰素的功能：从遗传性和获得性缺陷中获得启示

在过去的三十年里，通过对先天性免疫错误患者或其自身免疫表型的研究，人类 I 型和 II 型干扰素（IFNs）的基本功能和冗余功能已经得到了明确的界定，但人们对 III 型 IFNs 的了解却少得多。因遗传性 IL10RB 缺乏而导致细胞对 III 型 IFNs 没有反应的患者不会表现出明显的病毒性疾病，他们的炎症性疾病表型可以通过其他白细胞介素-10RB 依赖性途径的信号传递缺陷来解释。此外，遗传性干扰素刺激基因因子 3（ISGF-3）（STAT1、STAT2、IRF9）缺乏症患者也会出现病毒性疾病，这在遗传性 IFN 受体（IFNAR1/2）缺乏症患者身上也能看到。最后，自身抗体中和Ⅲ型IFN的患者没有明显的病毒性疾病倾向。因此，目前的研究结果表明，III 型 IFN 在人类体内基本上是多余的。人类 III 型 IFNs 的基本功能，尤其是抗病毒防御功能，仍有待发现。

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来源期刊

Current Opinion in Immunology 医学-免疫学

CiteScore

13.30

自引率

1.40%

发文量

审稿时长

67 days

期刊介绍： Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.

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