Association of low angiomotin-p130 and high YAP1 nuclear expression with adverse prognosis in epithelial ovarian cancer.

IF 2.5 4区生物学 Q3 CELL BIOLOGY Histology and histopathology Pub Date : 2025-01-01 Epub Date: 2024-05-07 DOI:10.14670/HH-18-758

Junna Cai, Xiaorui Han, Meng Li, Xiaoli Liu, Fengying Zhang, Xiaohua Wu

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引用次数: 0

Abstract

Objectives: The aim of our study was to examine the association of Angiomotin (Amot-p130) and Yes-associated protein 1 (YAP1) expressions and their prognostic significance in epithelial ovarian cancer (EOC).

Methods: A total of 100 primary EOC samples were obtained for immunohistochemical analysis of Amot-p130 and YAP1 expressions. Correlation analysis was performed between Amot-p130 or YAP1 and clinical factors. The overall survival time was calculated.

Results: Low Amot-p130 and high YAP1 nuclear expression were identified in 34 and 56 of 100 EOC tissues, respectively. Both low Amot-p130 and high YAP1 nuclear expression were associated with advanced tumor stage, high-grade carcinoma, and non-response to chemotherapy (p<0.05). They were also associated with shorter overall survival time (p<0.05) by log-rank test. A marker of low Amot-p130 and high YAP1 expression was associated with high-grade ovarian carcinoma, late-stage disease, non-response to chemotherapy, and shorter overall survival time (p<0.05).

Conclusions: Low Amot-p130 and high YAP1 nuclear expression can provide additional prognostic information for patients with EOC. A marker of low Amot-p130 and high YAP1 expression may be a potent predictor of poor prognosis in patients with epithelial ovarian cancer.

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上皮性卵巢癌中低 Angiomotin-p130 和高 YAP1 核表达与不良预后的关系

研究目的我们的研究旨在探讨上皮性卵巢癌（EOC）中Angiomotin（Amot-p130）和Yes-associated protein 1（YAP1）表达的相关性及其预后意义：方法：共采集了100例原发性EOC样本，对Amot-p130和YAP1的表达进行免疫组化分析。对Amot-p130或YAP1与临床因素进行相关性分析。计算总生存时间：结果：在100例EOC组织中，分别有34例和56例发现了低Amot-p130和高YAP1核表达。低Amot-p130和高YAP1核表达与肿瘤晚期、高级别癌和化疗无反应有关（ppp结论：低Amot-p130和高YAP1核表达与肿瘤晚期、高级别癌和化疗无反应有关：低Amot-p130和高YAP1核表达可为EOC患者提供额外的预后信息。Amot-p130低表达和YAP1高表达标记物可能是上皮性卵巢癌患者预后不良的有效预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Histology and histopathology 生物-病理学

CiteScore

3.90

自引率

0.00%

发文量

232

审稿时长

2 months

期刊介绍： HISTOLOGY AND HISTOPATHOLOGY is a peer-reviewed international journal, the purpose of which is to publish original and review articles in all fields of the microscopical morphology, cell biology and tissue engineering; high quality is the overall consideration. Its format is the standard international size of 21 x 27.7 cm. One volume is published every year (more than 1,300 pages, approximately 90 original works and 40 reviews). Each volume consists of 12 numbers published monthly online. The printed version of the journal includes 4 books every year; each of them compiles 3 numbers previously published online.