Correlation between the thyroid computed tomography value and thyroid function in hyperthyroidism: a retrospective study.

IF 2.5 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Annals of Nuclear Medicine Pub Date : 2024-08-01 Epub Date: 2024-05-24 DOI:10.1007/s12149-024-01938-0

Haruna Iwanaga, Naotoshi Fujita, Shinji Abe, Shinji Naganawa, Katsuhiko Kato

{"title":"Correlation between the thyroid computed tomography value and thyroid function in hyperthyroidism: a retrospective study.","authors":"Haruna Iwanaga, Naotoshi Fujita, Shinji Abe, Shinji Naganawa, Katsuhiko Kato","doi":"10.1007/s12149-024-01938-0","DOIUrl":null,"url":null,"abstract":"Objective: Radioiodine (I-131) therapy for hyperthyroidism is a well-established and safe treatment option. This study aimed to investigate the relationship between the computed tomography (CT) value and the function and volume of the thyroid gland by identifying the factors that induce changes in the CT value of patients with hyperthyroidism.Methods: This retrospective study evaluated 38 patients with Graves' disease and 10 patients with Plummer disease. To obtain the mean CT value and volume of the thyroid gland, the entire thyroid gland was set as the region of interest. A test dose of 3.7 MBq I-131 was administered before initiating I-131 therapy, and the radioiodine uptake (RIU) rate was assessed after 3, 24, 96, and 168 h. An approximate curve was plotted based on the RIU values obtained, and the effective half-life (EHL) was calculated. The correlation between the mean CT value and the volume of the thyroid gland, 24-h RIU, EHL, and the free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), and TSH receptor antibody (TRAb) levels was evaluated.Results: The CT value exhibited a significant positive correlation with EHL in patients with Graves' disease (r = 0.62, p < 0.0001) as well as patients with Plummer disease (r = 0.74, p < 0.05). However, it did not display any correlation with the remaining parameters.Conclusion: The CT value is significantly correlated with EHL, suggesting that it reflects thyroid function and is mainly related to the factors associated with iodine discharge.","PeriodicalId":8007,"journal":{"name":"Annals of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11282127/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Nuclear Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12149-024-01938-0","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/24 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Radioiodine (I-131) therapy for hyperthyroidism is a well-established and safe treatment option. This study aimed to investigate the relationship between the computed tomography (CT) value and the function and volume of the thyroid gland by identifying the factors that induce changes in the CT value of patients with hyperthyroidism.

Methods: This retrospective study evaluated 38 patients with Graves' disease and 10 patients with Plummer disease. To obtain the mean CT value and volume of the thyroid gland, the entire thyroid gland was set as the region of interest. A test dose of 3.7 MBq I-131 was administered before initiating I-131 therapy, and the radioiodine uptake (RIU) rate was assessed after 3, 24, 96, and 168 h. An approximate curve was plotted based on the RIU values obtained, and the effective half-life (EHL) was calculated. The correlation between the mean CT value and the volume of the thyroid gland, 24-h RIU, EHL, and the free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), and TSH receptor antibody (TRAb) levels was evaluated.

Results: The CT value exhibited a significant positive correlation with EHL in patients with Graves' disease (r = 0.62, p < 0.0001) as well as patients with Plummer disease (r = 0.74, p < 0.05). However, it did not display any correlation with the remaining parameters.

Conclusion: The CT value is significantly correlated with EHL, suggesting that it reflects thyroid function and is mainly related to the factors associated with iodine discharge.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

甲状腺计算机断层扫描值与甲亢患者甲状腺功能的相关性：一项回顾性研究。

目的：放射性碘（I-131）治疗甲状腺功能亢进症是一种行之有效的安全治疗方法。本研究旨在通过确定引起甲状腺功能亢进症患者 CT 值变化的因素，研究计算机断层扫描（CT）值与甲状腺功能和体积之间的关系：这项回顾性研究对38名巴塞杜氏病患者和10名普鲁姆病患者进行了评估。为了获得甲状腺的平均 CT 值和体积，将整个甲状腺设为研究区域。在开始 I-131 治疗前，患者接受了 3.7 MBq I-131 的测试剂量，并在 3、24、96 和 168 小时后评估了放射性碘摄取率（RIU）。根据 RIU 值绘制了近似曲线，并计算了有效半衰期（EHL）。评估了平均 CT 值与甲状腺体积、24 小时 RIU、EHL 以及游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、促甲状腺激素（TSH）和 TSH 受体抗体（TRAb）水平之间的相关性：巴塞杜氏病患者的 CT 值与 EHL 呈显著正相关（r = 0.62，p 结论：巴塞杜氏病患者的 CT 值与 EHL 呈显著正相关：CT值与EHL呈显著正相关，表明CT值能反映甲状腺功能，且主要与碘排放相关因素有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Annals of Nuclear Medicine 医学-核医学

CiteScore

4.90

自引率

7.70%

发文量

111

审稿时长

4-8 weeks

期刊介绍： Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine. The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.