History of Infertility and Risk of Colorectal Cancer.

IF 3.7 3区医学 Q2 ONCOLOGY Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-08-01 DOI:10.1158/1055-9965.EPI-24-0313

Leslie V Farland, Kimberly E Lind, Denise J Roe, Nazmus Saquib, Howard D Strickler, Lihong Qi, Cynthia A Thomson, Holly R Harris

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Abstract

Background: There has been limited prior research on the association between infertility and risk of colorectal cancer.

Methods: Data from postmenopausal women in the Women's Health Initiative were used to estimate the association between self-reported infertility (12 months of trying to get pregnant without achieving a pregnancy) and the risk of colorectal cancer using Cox proportional hazard models.

Results: No association was observed between infertility and risk of postmenopausal colorectal cancer [RR, 0.97; 95% confidence interval (CI), 0.87-1.08], invasive colorectal cancer (RR, 0.99; 95% CI, 0.88-1.10), or colorectal cancer mortality (RR, 0.89; 95% CI, 0.71-1.12).

Conclusions: Infertility was not found to be associated with colorectal cancer risk among postmenopausal women. Risk did not vary by specific infertility diagnoses.

Impact: Infertility may not be associated with colorectal cancer risk.

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不孕不育史与罹患结直肠癌的风险。

背景：关于不孕症与结直肠癌风险之间关系的研究十分有限：以前关于不孕症与结直肠癌风险之间关系的研究很有限：方法：利用妇女健康倡议（WHI）中绝经后妇女的数据，使用 Cox 比例危险模型估计自述不孕症（尝试怀孕 12 个月但未怀孕）与结直肠癌风险之间的关系：结果：未发现不孕症与绝经后结直肠癌风险（RR：0.97，95% CI：0.87-1.08）、浸润性结直肠癌（RR：0.99，95% CI：0.88-1.10）或结直肠癌死亡率（RR：0.89，95% CI：0.71-1.12）之间存在关联：结论：不孕症与绝经后妇女患结直肠癌的风险无关。结论：不孕症与绝经后妇女患结直肠癌的风险无关，风险也不因具体的不孕症诊断而异：影响：不孕症可能与结直肠癌风险无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

2.60%

发文量

538

审稿时长

1.6 months

期刊介绍： Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.